Central nervous system manifestations in patients with systemic lupus erythematosus. Review of pathogenetic aspects

CNS manifestation is considered as a diagnostic as well as prognostic important variation of SLE course. Disturbances of blood flow and immunopathologic process participate in its induction. Antineuronal antibodies and circulating immune complexes in liquor show tight relations to CNS involvement.     

CHROMATIC ROD VISION III. Duration of pre-stimulation varied

S tabell B. & S tabell U. Chromatic rod vision. III. Duration of pre-stimulation varied. Scand. J. Psychol ., 1972, 13 , 136–140.—The scotopic contrast hue was determined as a function of duration of pre-stimulation, together with the additive opponent hue. It is concluded that the red/blue ratio which has to be added to the additive opponent hue to produce the scotopic contrast hue, may change as a function of both wavelength and duration of pre-stimulation.     

CHROMATIC ROD VISION

S tabell B. & S tabell U. Chromatic rod vision. IV. Time between pre-and test-stimulation varied. Scand. J. Psychol ., 1972, 13 , 141–144.—The scotopic contrast hue was determined as a function of time between pre-and test-stimulation. As the interval increased, the scotopic hue was found to change from orange toward yellow in the 440–475 nm region of pre-stimulation and from violet-blue toward violet in the 550–595 nm region. It is concluded that (1) depending on wavelength of pre-stimulation, the processes in the red-green substance may revert to the mid-valued state faster or slower than the processes in the yellow-blue substance, and (2) the red/blue ratio of the violet hue which has to be added to the additive opponent hue to produce the scotopic contrast hue, may change as a function of time between pre- and test-stimulation.     

TRANSITION FROM ROD TO CONE VISION:III. Successive contrast anew

S tabell , U. & S tabell , B. Transition from rod to cone vision. III. Successive contrast anew. Scand. J. Psychol ., 1969, 10 , 140–144—The relation between the specific threshold level and the upper limit of the scotopic contrast color was investigated. The achromatic interval between the scotopic and the photopic component increased when time in darkness increased, and when pre-stimulation was reduced as regards intensity, duration, or cone/rod ratio. The results are interpreted on the basis of the opponent theory of color vision.     

RODS AS COLOR RECEPTORS IN SCOTOPIC VISION

With the method of successive contrast, all the principal colors have been observed when test-stimulating at levels of intensity within the photochromatic interval. Using the method of simultaneous contrast, blue and green colors have been observed within this area of intensity. It is concluded that rod activity must somehow initiate these color processes.     

A computerized system for monitoring and controlling intracranial electrical self-stimulation behavior

An automated system for measuring intracranial self-stimulation behavior is described. The system consists of two Commodore 6502 microcomputers interfaced with a constant-current generator and a standard operant chamber. The system hardware allows sine- and square-wave stimulation. Stimulus intensity can be varied in 256 steps between 0 and 100, 0 and 500, or 0 and 1,000 /µA. The system programs, which are written in machine language, allow the control of various schedules of reinforcement, the counting of operant responses and reinforcements, the measurement of interresponse intervals, and the storage of the data on disk. The software is designed for the determination of the threshold of reinforcement, on the basis of the titration of postreinforcement pauses caused by changeover in schedule control between concurrent continuous reinforcement and fixed ratio schedules.     

Endogenous and symptomatic schizophrenia. Wherein lies the difference?

It is the opinion of the present writer that endogenous and symptomatic schizophrenia are two completely different matters. By classical symptomatology it is impossible to establish the distinction in every individual case. Nevertheless, in not one of the published cases known to us did Bonhoeffer err in his diagnosis of the one or the other. Evidently he made use of additional characteristica gathered in practice, about which he himself may not always have been quite clear.     

A kinematic analysis of anticipatory coarticulation in the speech of anterior aphasic subjects using electromagnetic articulography

An investigation was made into the extent and time course of anticipatory coarticulation in the speech of two normal and two anterior aphasic, German-speaking subjects. Both labial and velar coarticulation gestures were investigated. Subjects produced sentences containing target words contrasting in postconsonantal vowel rounding (e.g., [geli:ge]/[gely:gel]) and in nasality (e.g., [ti:de]/[ti:ne]). Speech kinematics were monitored by means of electromagnetic articulography. The data revealed that for correct productions, aphasic speakers' coarticulatory patterns were more highly variable than those of control subjects. These differences, however, were found chiefly for spatial displacement characteristics, while the temporal aspects of articulator movement necessary for anticipatory coarticulation appeared largely intact. Articulator mistiming did not appear to explain a small corpus of stop/nasal substitution errors produced by one of the aphasic speakers.     

The neurocognitive basis of autism

The cognitive study of the underlying mental abnormalities in autism has advanced rapidly, while the biological study of the underlying brain abnormalities and of putative genetic mechanisms is lagging somewhat behind. However, the linking of cognitive and biological studies has become a real possibility. Developmental cognitive neuroscience has transformed our understanding of this enigmatic disorder, which was once misguidedly thought to be caused by maternal rejection. The hypothesis of a specific theory of mind deficit was a crucial step in this process. It explains the puzzle of the characteristic social and communication impairments of autism and allows for the fact that they can coexist with good general abilities. This hypothesis has been widely accepted and a start has been made at pinpointing the brain basis of theory of mind. The non-social impairments of autism have now become a major focus for cognitive research. One theory proposes dysfunction in executive processes, in an attempt to explain repetitive behaviour and inflexibility. Another theory proposes weak information integration, in an attempt to explain narrow interests and special talents. Autism research has thus stimulated ideas on important mind-brain systems that may be dedicated to the development of social awareness, executive functions and integrative processing.