Determination of dipeptidyl aminopeptidase activities in the cerebrospinal fluid

The investigation of enzyme activity in cerebrospinal fluid has been without relevant results for laboratories analysing spinal fluid. For neurochemical purposes, it is interesting that the Substance P is convered by Depeptidyl-aminopeptidase IV (DP IV), liberating dipeptides. The hydrolysis of nitroanilids of the form Xaa-Pro-NHNp in cerebrospinal fluid was analysed using them as peptidases substrates. Finally a method for measuring the activity was proposed.     

Acoustically evoked brain stem potential in Wilson disease

By 48 patients with Wilson's disease the brainstem acoustic evoked potentials were stated. There were 35 pathological findings (73%), 13 were normal (27%). The waves, determined by the middle and upper brainstem (Pons and Mesencephalon) showed most of all pathological changes. Those patients with forms of Wilson's disease called Pseudoskelerose and Pseudoparkinson showed the most pathological findings. But one could watch these findings by about 30% of patients in preclinical stage. This method can possibly be used for early detection of disorders of brainstem functions and in the same way it can be used for control of treatment by patients in preclinical stage.     

A patient who had trouble with geography

Aspects of geography are important in relation to the establishment of body ego, since they inevitably supply from the external world the early symbols that represent in the mind the basic elements of infantile experience in regard to body parts, functions, and relationships with primal objects. The accretional inter-twining of all subsequent psychic conflicts can therefore be expressed in symbolic geographic terms. These conflicts center on the developmentally evolving meanings of the mother's body as epitomized in the riddle of the Sphinx. Illustration of the concepts includes a brief clinical report and selected literary and mythological examples.     

Value of mechanographic studies in neuromuscular function diagnosis

Mechanographic examinations have hitherto played only a minor role in general clinical neuromuscular functional diagnostics. The purpose of this contribution is, therefore, to present an appropriate recording apparatus (W. Zett , 1969), to report on the values that can be considered normal and to outline the diagnostic value of the method using clinical applications as examples. Special value is attached to simultaneous recording of the EMG and the mechanograph because this method permits differentiated conclusions to be drawn regarding disturbances in muscular activity, the electromechanical coupling and the actual process of contraction. The method is also important for pharmacological investigations and should be used principally in connection with musclepathology for objectifying the effects of medication.     

Smoking and pain--a method of limits and sensory decision theory analysis

The effects of tobacco smoking on responses to electrical stimulation were studied according to a Method of Limits (ML) threshold analysis and a Sensory Decision Theory (SDT) analysis. For the ML procedure, Detection Threshold (DT), Pain Threshold (PT) and Tolerance Level (TL) measures were obtained. For the SDT procedure, nonparametric estimates of capacity to discriminate between stimulus intensities (P(A)) and response criterion (B) were calculated. There was no main effect of tobacco smoking on responses to electrical stimulation. Males had consistently higher ML thresholds than females in both the NS and S condition. Males also tended to increase in DT and PT after smoking. From a comparison between the effects of smoking on ML and SDT measures it was suggested that PT is related mainly to sensory factors and TL to response factors.