Nifedipine blocks retention of a visual discrimination task in chicks.

Reports that the dihydropyridine Ca2+ channel antagonists may facilitate memory led to the present study of the behavioral effects of nifedipine. Ninety-two 4-day-old male chicks received 0, 100 nM, 100 microM, or 10 mM nifedipine. Drugs were administered in volumes of 2 microliters into the fourth cerebral ventricle 5 min before training on a visual discrimination task. Nifedipine did not produce any detectable changes in behavior during acquisition trials. Retention, however, was impaired 24 h after training in the 100 nM and 100 microM nifedipine-treated chicks, which made significantly more errors than controls. Nifedipine did not affect the amount of time required to complete the task. No effects on body weight gain were detected, suggesting that the memory impairment was not due to a change in feeding behavior. These data are discussed in terms of the role of calcium-dependent processes in memory.     

Multivariate genetic analysis of specific cognitive abilities in the Colorado adoption project at age 7

A multivariate hierarchical model of specific cognitive abilities was fitted to data from 7-year-old adopted and nonadopted sibling pairs in the Colorado Adoption Project in order to assess differential genetic influence on specific mental abilities. Model fitting results and Schmid-Leiman (Schmid & Leiman, 1957) transformations reveal significant heritable variation for verbal, spatial, and memory factors independent of general cognitive ability for the eight ability tests examined. In contrast, environmental influences are primarily measure-specific. The results suggest genetic effects in middle childhood that differentially influence mental ability scores.     

Microdialysis administration of vasopressin and vasopressin antagonists into the septum during pole-jumping behavior in rats.

Wistar rats (n = 95) were trained in a pole-jumping apparatus (10 trials/session/day) to investigate the involvement of centrally and peripherally released endogenous AVP in their acquisition rate and to examine the feasibility of the microdialysis technique for the administration of peptides during a behavioral test. After session 1, a microdialysis probe was implanted into the septum; during sessions 2 and 3 the probe was perfused with artificial cerebrospinal fluid (aCSF) alone or containing either AVP (delivered amount via the probe: 0.2 ng) or the V1 (d(CH2)5Tyr(Me)AVP, 5.0 ng) or the V2/V1 (d(CH2)5-D-Tyr(Et)VAVP, 5.0 ng) antagonist. Administration of AVP via microdialysis into the septum failed to alter the acquisition rate of pole jumping. Also, ip application of both hypertonic saline and the AVP V1 antagonist (10 micrograms) in another experiment failed to show a significant effect upon behavior. Septal administration of the V1 or the V2/V1 antagonist via microdialysis, however, produced a significantly impaired performance. The results indicate that AVP release within the septum is involved in the acquisition of pole-jumping behavior probably mediated by the V1 receptor subtype. An additional involvement of the V2 receptor subtype, however, cannot be entirely excluded. The microdialysis technique proved to be a potent tool to administer substances concomitantly with behavioral tests.     

Design and implementation of a program for AIDS prevention in female prostitutes

The Companeros model of HIV infection prevention in Ciudad Juarez, Mexico, is presented as conceived by the National Institute of Drug Abuse (NIDA). 518 women who were IV drug users, sexual partners of drug addicts, or prostitutes were requested to participate, and 232 consented. Initial and follow-up AIDS assessments were utilized along with an assessment of sociodemographic variables, including knowledge, sexual behavior, use and abuse of drugs, and previous health history. Educative sessions about AIDs and sexually transmitted diseases (STDs) included group discussions and interaction, video watching, personal experiences, and sociodramas. 61% of prostitutes were 29, 12.6% were 13-19 years old, 31.1% were aged 30-39, and 8.9% were 40. 11% had no formal education, 58% had 6 years of primary and part of 3 years of secondary education, only 18.6% completed secondary education; and 13% had higher education. 19% lived in a hotel or shelter. Family disintegration reached 44%; these women did not live with their children. Only 5.2% thought they had excellent health, 51% said they had good health, 31% stated they had average health, and 12% admitted having had health problems. 14.6% had genital ulcers, 1.3% had herpes, 15% had gonorrhea, and 10% had syphilis. Since IV drug use among these women was almost nonexistent sexual relations constituted the principal risk factor. Responses to a questionnaire showed that the most frequent sexual behavior was vaginal penetration followed by fellatio; anal penetration was less common. 34.9% of the women practiced fellatio without protection, 16.3% had anal intercourse without protection. The proportion of AIDS cases in Mexico in women of reproductive age was growing at an exponential rate, possible because of misinformation about AIDS, a history of STDs, and a low rate of condom use.     

Patterns of coping with cancer.

We identified five patterns of coping in a sample of 603 cancer patients: "seeking or using social support," "focusing on the positive," "distancing," "cognitive escape-avoidance," and "behavioral escape-avoidance." Relationships of these coping patterns to sociodemographic characteristics, medical factors, stress appraisals, psychotherapeutic experience, and emotional distress were tested using correlational and regression techniques. Type of cancer, time since diagnosis, and whether a person was currently in treatment had few or no relationships to coping. The specific cancer-related problem (e.g., pain, fear of future) was also not associated with how individuals coped. Perceptions of its stressfulness, however, were related to significantly more coping through social support and more of both forms of escape-avoidance. Coping through social support, focusing on the positive, and distancing was associated with less emotional distress, whereas using cognitive and behavioral escape-avoidance was associated with more emotional distress. Implications of the results for understanding coping processes and intervention with cancer patients are discussed.     

Looking at pictures but remembering scenes.

Ss tend to remember close-up photographs as having had extended boundaries (Intraub & Richardson, 1989). Three alternate explanations were tested: object completion, distortion toward a perceptual schema, and normalization toward a prototypic view. In three experiments, 55-130 undergraduates viewed 16 close-up, prototypic, or wide-angle views of objects for 15 s each. Immediately or 48 hr later, they rated test pictures on a 5-point scale as "same", "closer up", or "father away." Results ruled out object completion because boundary extension occurred when the picture contained no incomplete objects. Immediate tests supported the perceptual schema hypothesis because all unidirectional distortions involved boundary extension. Delayed tests were more suggestive of a memory schema effect because wide-angle pictures yielded boundary restriction. A two-component model of picture processing is proposed.     

Anterior cerebral asymmetry and the nature of emotion.

This article presents an overview of the author's recent electrophysiological studies of anterior cerebral asymmetries related to emotion and affective style. A theoretical account is provided of the role of the two hemispheres in emotional processing. This account assigns a major role in approach- and withdrawal-related behavior to the left and right frontal and anterior temporal regions of two hemispheres, respectively. Individual differences in approach- and withdrawal-related emotional reactivity and temperament are associated with stable differences in baseline measures of activation asymmetry in these anterior regions. Phasic state changes in emotion result in shifts in anterior activation asymmetry which are superimposed upon these stable baseline differences. Future directions for research in this area are discussed.     

Learned helplessness in chess players: The importance of task similarity and the role of skill

Summary The effects of noncontingency between subjects' responses and outcomes were examined with respect to treatment-and-posttest similarity and skill in the task. The experimental design consisted of three groups. The first group had to solve chess problems with objective solutions and received veridical feedback; each member of the second group faced problems with no objective solutions, and received the same feedback as the member of the first group he was yoked with, but without any control on it; the control group received a waiting task. It was found at the end of the experiment that the group with unsolvable problems was more depressed than the two other groups. The mid-strength players were the most sensitive to the manipulation, and the weakest players showed little effect of learned helplessness. It was also found that the effects were proportional to the degree of similarity between the treatment and the posttest. The results limit the domain of applicability of the learned-helplessness model.