Heart rate variability and drawing impairment in hypoxemic COPD

We studied 54 patients with hypoxemic chronic obstructive pulmonary disease (COPD). The Mini Mental State Examination and the Mental Deterioration Battery were used for neuropsychological assessment. Heart rate variability (HRV) was assessed based on 24-h Holter ECG recording. Mann–Whitney test was used to compare HRV parameters of patients performing normally or abnormally on individual neuropsychological tasks. Spearman’s rho was used to investigate the correlations between HRV parameters and neuropsychological scores, indexes of health status or COPD severity. Patients with defective performance at copying drawings with landmarks (CDL) test (N = 23) had lower very low frequency (VLF) power with respect to patients with normal performance (N = 31) (24 h: median 213; interquartile range 120–282 vs. 309; 188–431 ms², p = 0.043; daytime: 202; 111–292 vs. 342; 194–397 ms², p = 0.039). The CDL score correlated with the VLF power (24 h: ρ = 0.27, p = 0.049; daytime: ρ = 0.30, p = 0.028), and the normalized low frequency/high frequency (LF/HF) ratio (24 h: ρ = 0.27, p = 0.05; daytime: ρ = 0.33, p = 0.015). Sympathetic modulation decreased for increasing severity of COPD. In conclusion, drawing impairment correlates with depressed sympathetic modulation in patients with COPD, and both might be indexes of COPD severity.     

Five-factor personality traits and age trajectories of self-rated health: the role of question framing

We examined the influence of personality traits on mean levels and age trends in 4 single‐item measures of self‐rated health: general rating, comparison to age peers, comparison to past health, and expectations for future health. Community‐dwelling participants (N = 1,683) completed 7,474 self‐rated health assessments over a period of up to 19 years. In hierarchical linear modeling analyses, age‐associated declines differed across the 4 health items. Across age groups, high Neuroticism and low Conscientiousness, low Extraversion, and low Openness were associated with worse health ratings, with notable differences across the 4 health items. Furthermore, high Neuroticism predicted steeper declines in health ratings involving temporal comparisons. We consider theoretical implications regarding the mechanisms behind associations among personality traits and self‐rated health.     

Improved mental representation of space in beginner orienteers

The purpose of the present study was to monitor any improvement in orienteering skills attributable to acquiring a better mental representation of space. Two groups were examined: the experimental group, who attended 6 mo. of orienteering lessons, versus the control group, who did jogging training instead. Each group, consisting of 20 children, was tested on the Corsi Block-tapping Test, run Forward and Backward, and the Star-Butterfly Test. Pre- and post-tests were administered. In the experimental group, scores increased in mean complexity from pre- to post-test on the Forward and the Backward Corsi tests, while on the Star-Butterfly Test both time and mistakes had decreased after the training. In the control group, mean complexity and Star-Butterfly Test scores were unchanged from pre- to post-test. These results showed that after continual training in orienteering techniques, the orienteering group was able to remember and repeat sequences of events with greater precision than before the training, while these skills were unchanged in the control group after training in jogging.     

Multisensory Assessment of Acoustic Comfort Aboard Metros: a Virtual Reality Study

In this study, a multisensory methodology is used to assess acoustic comfort aboard different real‐world metros by means of subjective annoyance and cognitive performance measures. Two experimental conditions were compared: unimodal versus bimodal. Immersive virtual reality was used to simulate journeys aboard metro coaches. Participants performed four tasks (Rey Test, Verbal Fluency, Backward Counting and Auditory Words Discrimination) while listening to metro sounds (unimodal condition) or while listening to metro sounds within a virtual metro coach (bimodal condition). At the end of each journey, participants reported their degree of noise annoyance. The results showed that cognitive performances were worse in the bimodal than in the unimodal condition. Moreover, the bimodal condition affected negatively the capacity to discriminate words and to count backward. However, reported noise annoyance was higher in the unimodal than bimodal condition. The theoretical and practical implications of these findings are discussed. Copyright © 2012 John Wiley & Sons, Ltd.     

Eye movements and bisection behavior in spatial neglect syndrome: representational biases induced by the segment length and spatial dislocation of the stimulus

The present study explored behavioral and eye-movement measures in unilateral neglect patients in response to online bisection task (unfilled gap line). Two different tasks supported the bisection performance, a pointing and a grasping strategy. It was explored whether these different strategies may influence subjects' behavioral and eye-movement measures in response to different segment features: segment length (from shorter to longer) and segment spatial dislocation (from right to left spatial location). Consistent spatial biases were found for both bisection responses, fixation count, and duration, as well as for the first fixation count in case of pointing task. An "extreme-left" gradient effect was suggested and discussed, with patients' behavioral and eye measures more impaired. On the contrary, the patients' performance overlaps with the controls' one in case a grasping task. The direct link of visual pointing and grasping strategy, respectively, with the two cortical ventral and dorsal pathways was adduced to explain our results.     

Eye movements and bisection behavior in spatial neglect syndrome: representational biases induced by the segment length and spatial dislocation of the stimulus

The present study explored behavioral and eye-movement measures in unilateral neglect patients in response to online bisection task (unfilled gap line). Two different tasks supported the bisection performance, a pointing and a grasping strategy. It was explored whether these different strategies may influence subjects’ behavioral and eye-movement measures in response to different segment features: segment length (from shorter to longer) and segment spatial dislocation (from right to left spatial location). Consistent spatial biases were found for both bisection responses, fixation count, and duration, as well as for the first fixation count in case of pointing task. An “extreme-left” gradient effect was suggested and discussed, with patients’ behavioral and eye measures more impaired. On the contrary, the patients’ performance overlaps with the controls’ one in case a grasping task. The direct link of visual pointing and grasping strategy, respectively, with the two cortical ventral and dorsal pathways was adduced to explain our results.     

Individual reactions to a multisensory immersive virtual environment: the impact of a wind farm on individuals

The aim of this study was to assess the impact of a wind farm on individuals by means of an audio-visual methodology that tried to simulate biologically plausible individual-environment interactions. To disentangle the effects of auditory and visual components on cognitive performances and subjective evaluations, unimodal (Audio or Video) and bimodal (Audio + Video) approaches were compared. Participants were assigned to three experimental conditions that reproduced a wind farm by means of an immersive virtual reality system: bimodal condition, reproducing scenarios with both acoustic and visual stimuli; unimodal visual condition, with only visual stimuli; unimodal auditory condition, with only auditory stimuli. While immersed in the virtual scenarios, participants performed tasks assessing verbal fluency, short-term verbal memory, backward counting, and distance estimations (egocentric: how far is the turbine from you?; allocentric: how far is the turbine from the target?). Afterwards, participants reported their degree of visual and noise annoyance. The results revealed that the presence of a visual scenario as compared to the only availability of auditory stimuli may exert a negative effect on resource-demanding cognitive tasks but a positive effect on perceived noise annoyance. This supports the idea that humans perceive the environment holistically and that auditory and visual features are processed in close interaction.     

Prevalence and Significant Determinants of Post-traumatic Stress Disorder in a Large Sample of Patients with Multiple Sclerosis

Chronic and life-threatening neurodegenerative diseases may be associated with post-traumatic stress disorder (PTSD). Therefore, the current study was an investigation of the prevalence of PTSD in multiple sclerosis (MS) patients, and identification of significant determinants of PTSD. Two hundred thirty-two MS patients were consecutively recruited and screened for the presence of PTSD with the Impact of Event Scale-Revised, corroborated by the Structured Clinical Interview for DSM-IV. Furthermore, participants were administered the Hospital Anxiety and Depression Scale and the Fatigue Severity Scale. Twelve patients (12/232, i.e. 5.17 %) were diagnosed as suffering from PTSD. Levels of education, anxiety and depression were significant determinants of the presence of PTSD. The role played by the levels of education, anxiety and depression in determining the presence of PTSD has been discussed. Further research on the psychological features of neurodegenerative diseases is urgently needed in order to plan appropriate treatments and improve patients’ quality of life.     

A General Population Twin Study of Conduct Problems and the Auditory P300 Waveform

Reduced amplitude of the P300 event-related potential has been consistently associated with a variety of externalising problems, including conduct disorder. The few available genetically-informative studies of these relationships, however, were conducted among adolescents/adults (i.e., at an age when conduct disorder has typically already become manifest). Among 200 general population twins with a mean age of 9 years (range 6–14 years), we studied the relationship between the P300 waveform elicited by an auditory oddball task and the DSM-oriented conduct problems scale of the Child Behavior Checklist 6–18. Conduct problems scores were negatively and significantly correlated (r?=??0.19, p?=?0.01) with P300 amplitude; correlations between P300 amplitude and the other DSM-oriented Child Behavior Checklist scales were non-significant, except for oppositional defiant problems (p?=?0.01). We found moderate heritability estimates for both P300 amplitude (0.58, CI:0.37;0.73) and conduct problems (0.52, CI:0.25;0.70). Bivariate twin analyses indicated that the covariation between these two phenotypes can be explained by additive genetic factors only, with a genetic correlation of ?0.33. An association between reduced P300 amplitude and conduct problems can be substantiated already in childhood, at an age that precedes the most typical onset of conduct disorder. This relationship appears to be genetic in nature. Reduced P300 amplitude can represent a valuable marker for conduct problems, and can contribute to the early identification of children at high-risk for conduct disorder.