Unravelling the Interplay Between Genetic and Environmental Contributions in the Unfolding of Personality Differences from Early Adolescence to Young Adulthood

In two studies, we examined the genetic and environmental sources of the unfolding of personality trait differences from childhood to emerging adulthood. Using self‐reports from over 3000 representative German twin pairs of three birth cohorts, we could replicate previous findings on the primary role of genetic sources accounting for the unfolding of inter‐individual differences in personality traits and stabilizing trait differences during adolescence. More specifically, the genetic variance increased between early (ages 10–12 years) and late (ages 16–18 years) adolescence and stabilized between late adolescence and young adulthood (ages 21–25 years). This trend could be confirmed in a second three‐wave longitudinal study of adolescents' personality self‐reports and parent ratings from about 1400 Norwegian twin families (average ages between 15 and 20 years). Moreover, the longitudinal study provided evidence for increasing genetic differences being primarily due to accumulation of novel genetic influences instead of an amplification of initial genetic variation. This is in line with cumulative interaction effects between twins' correlated genetic makeups and environmental circumstances shared by adolescent twins reared together. In other words, nature × nurture interactions rather than transactions can account for increases in genetic variance and thus personality variance during adolescence. © 2019 European Association of Personality Psychology     

Building youths' resilience within a psychiatric outpatient setting: results from a pilot clinical intervention project

The relevance of resilience research for clinical practice has not yet been established. In this intervention pilot study, the aim was to explore how group work based on enhancing the participants' creativity, self-efficacy, active coping, and sense of continuity could be utilized within a clinical context for adolescents with stressful background experiences. 31 participants and 24 parents completed pre-, post-, and 1-yr. follow-up assessments of the youths' behavior difficulties, as well as depression, positive life attitude, coping, and prosocial behavior. Apart from a drop in self-rated prosocial behavior, no significant treatment effects were found. Implications for clinical practice and research are indicated.     

Uptake of BRCA1 Genetic Testing in Adult Sisters and Daughters of Known Mutation Carriers in Norway

This study was undertaken to examine transmission of information to first-degree relatives of BRCA1 mutation carriers and uptake of genetic testing. The intention was to consider revision of current legislation related to privacy if information on life-saving health care was not disseminated to at-risk family members. The Norwegian Radium Hospital provides clinical genetics services for families at high risk for hereditary breast and ovarian cancer. Together with major hospitals nationwide we provide medical surveillance. Nearly all expenses are covered by the National Health insurance. Because of the high number of families with founder mutations in BRCA1, we are in a unique position to gather information about these groups. Within a consecutive series, we identified 75 BRCA1 mutation carriers and registered information transmission and uptake of genetic testing 6 months or more after the index mutation carriers had been informed about their mutation status. These 75 BRCA1 mutation carriers had 172 living first-degree relatives, aged 18 years or older (84 females, 88 males). Forty-four out of 54 (81.5%) of females over 30 had opted for genetic testing. The testing rate among all relatives was 43%. At any age, 63% of the females underwent genetic testing compared with 24% of the males (p<0.05). The overwhelming majority of adult females at risk opted for genetic testing. Males with daughters more frequently than males without daughters asked for testing. The findings give neither reason to reconsider legislation on privacy, nor for us to consider more aggressive methods of contacting relatives.     

Age Affects Strategic But Not Spontaneous Recall in 35- and 46-Month-old Children

ABSTRACT

It is well documented that young children have difficulties with strategically remembering past events. Recent evidence on event memory in 35- and 46-month-old children suggests that strategic retrieval (yes/no questions) improves with age, whereas spontaneous retrieval is relatively unaffected by age. We here replicate and extend those findings (N = 124): First, a novel free (strategic) recall test was added to improve ecological validity. Second, the free recall procedure allowed us to make direct comparisons between spontaneous and free strategic recall relative to age. The free recall test revealed similar results in the standard yes/no questions (older children outperformed younger). The direct comparison between spontaneous and free recall revealed a reliable interaction between age and retrieval mode: While the children’s age did not affect spontaneous recall, the 46-month-olds outperformed the 35-month-olds on the free recall test. The results add to the accumulating evidence that spontaneous recall of events is an early developmental achievement.     

Depression and cognitive sequelae registered within the first year among young Danish TBI survivors

The aim of the study was to determine the proportion of depression and cognitive sequelae among young (15-30 years) Danish TBI survivors referred to interdisciplinary evaluation through a nationwide government-initiated health initiative. The cross-sectional study is based on data from the “Danish register for young adults with acquired brain injury” on TBI survivors included from October 2013 to December 2016. The main measures were Major depression inventory, Trail making test A and B, Fluency, Word learning with selective reminding, Matrix reasoning, Coding and Glasgow outcome scale - extended (GOS-E). During the study period, 131 young TBI survivors were referred to one of five national outpatient clinics. Ninety-six had complete data and of these 14.6% fulfilled the ICD-10 diagnostic criteria for depression and 34.4% had cognitive sequelae. An association was found between depression and cognitive sequelae (p = 0.004). Patients with both depression and cognitive sequelae (n = 10) had a significantly lower mean score on GOS-E (p = 0.0001). Depression and cognitive sequelae were frequent and associated with a poorer global functional outcome among young TBI survivors referred within a year after trauma. This finding and the notion that only 20% of the expected TBI population was referred to this nationwide health initiative indicate an unacknowledged need for interdisciplinary follow-up.     

Big Five personality traits and allostatic load in midlife

Objective: To examine the cross-sectional associations of Big Five personality traits with midlife allostatic load, including the role of sex, socio-demographic factors and health-related behaviours.

Design: Cross-sectional analyses of 5512 members of the Copenhagen Aging and Midlife Biobank, aged 49–63 years, 69% men.

Main outcome measure: Allostatic load (AL) based on 14 biomarkers representing the inflammatory, cardiovascular and metabolic system.

Results: Due to significant sex?×?trait interactions, analyses were stratified by sex. Openness and Conscientiousness were inversely associated with AL in both sexes, and Extraversion was positively associated with AL in men. Adjusting for socio-demographic factors significantly attenuated the association of Openness in both sexes and of Extraversion in men, for whom the inverse association of Agreeableness with AL was strengthened. Further adjusting for health-related behaviours, the Conscientiousness-AL association was attenuated but remained significant, and Agreeableness remained significantly associated with AL in men.

Conclusion: Results imply that higher levels of Agreeableness (in men) and Conscientiousness are associated with lower levels of AL above and beyond socio-demographic factors and health-related behaviours. The study further contributes by demonstrating the relevance of sex?×?trait and trait?×?trait interactions in the personality-health literature.