Effects of cognitive load on neural and behavioral responses to smoking-cue distractors

Smoking cessation failures are frequently thought to reflect poor top-down regulatory control over behavior. Previous studies have suggested that smoking cues occupy limited working memory resources, an effect that may contribute to difficulty achieving abstinence. Few studies have evaluated the effects of cognitive load on the ability to actively maintain information in the face of distracting smoking cues. For the present study, we adapted an fMRI probed recall task under low and high cognitive load with three distractor conditions: control, neutral images, or smoking-related images. Consistent with a limited-resource model of cue reactivity, we predicted that the performance of daily smokers (n = 17) would be most impaired when high load was paired with smoking distractors. The results demonstrated a main effect of load, with decreased accuracy under high, as compared to low, cognitive load. Surprisingly, an interaction revealed that the effect of load was weakest in the smoking cue distractor condition. Along with this behavioral effect, we observed significantly greater activation of the right inferior frontal gyrus (rIFG) in the low-load condition than in the high-load condition for trials containing smoking cue distractors. Furthermore, load-related changes in rIFG activation partially mediated the effects of load on task accuracy in the smoking-cue distractor condition. These findings are discussed in the context of prevailing cognitive and cue reactivity theories. These results suggest that high cognitive load does not necessarily make smokers more susceptible to interference from smoking-related stimuli, and that elevated load may even have a buffering effect in the presence of smoking cues under certain conditions.     

Relations among functional systems in behavior analysis

This paper proposes that an organism's integrated repertoire of operant behavior has the status of a biological system, similar to other biological systems, like the nervous, cardiovascular, or immune systems. Evidence from a number of sources indicates that the distinctions between biological and behavioral events is often misleading, engendering counterproductive explanatory controversy. A good deal of what is viewed as biological (often thought to be inaccessible or hypothetical) can become publicly measurable variables using currently available and developing technologies. Moreover, such endogenous variables can serve as establishing operations, discriminative stimuli, conjoint mediating events, and maintaining consequences within a functional analysis of behavior and need not lead to reductionistic explanation. I suggest that explanatory misunderstandings often arise from conflating different levels of analysis and that behavior analysis can extend its reach by identifying variables operating within a functional analysis that also serve functions in other biological systems.     

Mortality salience and religion: divergent effects on the defense of cultural worldviews for the religious and the non‐religious

Religious and non‐religious individuals differ in their core beliefs. The religious endorse a supernatural, divinely inspired view of the world, while the non‐religious hold largely secular worldviews. As a result they may respond differently to existential threats. Three studies confirmed this prediction. After a mortality salience (MS) or control prime, Canadian participants read, and responded to, an essay hostile to Western civilization, allegedly written by a radical Muslim student. Results indicated that the non‐religious reliably showed the conventional cultural worldview defense by devaluating the content of the message and decreasing support for the civil rights of anti‐Western individuals when death was salient. No such effect was found for the religious. Religious and non‐religious participants did not differ in self‐esteem levels or in death‐thought accessibility. These results suggest that a religious stance among believers plays a defensive role against the awareness of death. Copyright © 2008 John Wiley & Sons, Ltd.     

Inhibition of matrix metalloproteinase activity disrupts reconsolidation but not consolidation of a fear memory

The reconsolidation hypothesis posits that memories that have been reactivated can be either enhanced or disrupted by pharmacological manipulation. Synaptic plasticity is presumed to underlie the reconsolidation process. Matrix metalloproteinases are proteins that regulate the extracellular matrix involved in plasticity events, and these proteins have recently been shown to influence learning and memory. However, all studies on the role of matrix metalloproteinases in learning and memory have employed tasks that rely on contextual cues. The goal of this study was to determine the extent to which FN-439 would disrupt the consolidation and/or reconsolidation of a fear memory associated with a conditioned stimulus that signaled tone-shock pairings and that was independent of contextual cues. Male Sprague-Dawley rats were given infusions of FN-439 (35 microg intracerebroventricular) 30 min prior to conditioning (tone-shock paired association) or 30 min prior to a single reactivation session given 24h after conditioning. Administration of FN-439 did not disrupt consolidation of the freezing response when the tone (conditioned stimulus) was presented. In contrast, FN-439 infusion disrupted reconsolidation of the fear memory in a reactivation-dependent manner. The reduced freezing behavior was not due to a decrease in general anxiety levels, since FN-439 had no effect on the percent of open-arm time or open-arm entries in an elevated-plus maze task. Thus, we demonstrated for the first time that matrix metalloproteinase inhibition in the brain is capable of disrupting the reconsolidation of a tone-shock association memory that does not depend on contextual cues. The finding that a fear response to a previously paired conditioned stimulus can be disrupted by treatment with an MMP inhibitor during a single reactivation session suggests that this class of compounds may have therapeutic potential for posttraumatic stress disorder and/or simple phobias.     

Equity and derogation of those against whom we have aggressed

Casting the classic provocation-retaliation paradigm in an equity framework, we hypothesized that persons realizing their retribution was excessive would derogate their victim, but only when they did not anticipate an opportunity to compensate her. After retaliating against a peer who had harshly evaluated their essays, 40 female undergraduates were informed that either a serious or mild misfortune had recently been suffered by their partner, and were led to believe that at the outset of the experiment they had carelessly overlooked this “mitigating” information. Half the participants anticipated a later opportunity to do a favor for the other woman. Regardless of the severity of the mitigating information the women were more negative in their evaluation of the partner when they did not anticipate a subsequent opportunity to do the partner a favor. The results are discussed in terms of equity restoration in reactions to having aggressed. © 1993 Wiley-Liss, Inc.     

Do Unilateral Right and Left Face Contractions Induce Positive and Negative Emotions? A Further Test of Schiff and Lamon's (1989) Hypothesis

Schiff and Lamon (1989) proposed that unilateral face contractions induce positive or negative changes in emotion depending on the side of contraction; support for this proposal, however, has been mixed. In a new test, 40 right-handed and 38 left-handed men performed four alternating face contractions (LRLR or RLRL) and, after each one, completed a different version of the Depression Adjective Checklist (Lubin, 1994). A repeated-measures ANCOVA failed to reveal any significant effect of side of face contraction or handedness on direction of emotion change. Instead, regardless of side of contraction, the subjects' negative emotional state increased significantly across the four contractions with the degree of change being significantly related to the subjects' reported level of difficulty in holding the contraction irrespective of whether the more difficult side was the left or the right.     

Medication Administration By Family Members of Dependent Elders In Shared Care Arrangements

Twenty-three long-term care family caregivers whose care-recipients were enrolled in adult day care programs participated in face-to-face, semistructured interviews designed to learn more about their medication administration experiences. Two distinct styles of decision making were identified: self-directed and physician-directed. To help them with their medication administration responsibility, both groups used primary (physicians, pharmacists, or both) and secondary sources of information (the internet, information hotlines, nurses, more experienced caregivers, and family members with health backgrounds). Self-directed caregivers, who were significantly younger than the physician-directed caregivers, were twice as likely to report use of secondary sources of information to manage their medication administration tasks. Secondary sources of information appear to be important for the development of a caregiver's maturation and critical thinking skills over the long term and need more attention from formal providers in shared care relationships with family caregivers.     

2004 CAROLYN SHERIF AWARD ADDRESS: HEART DISEASE AND GENDER INEQUITY

Individual patient records from the National Hospital Discharge Survey for 1988 and 1998 comprising approximately 10 million cases were the basis for a binary logistic regression model to predict coronary artery bypass graft. Patterns in 1988 and in 1998 indicated a dramatic and pernicious gender discrepancy in medical decisions involving bypass surgery. Overall, men were twice as likely to have bypass as were women with comparable medical profiles. This result was particularly evident for women in their 40s and 50s, when angina was a primary diagnosis, and in the presence of any comorbid condition (e.g., diabetes or hypertension). Failure to pursue proactive case management of women with heart disease costs women's lives.