On Not Confusing the Tree of Trustworthy Statistics with the Greater Forest of Good Science: A Comment on Simmons et al.’s Perspective on Pre‐registration

In this commentary on Simmons, Nelson, and Simonsohn (this issue), we examine their rationale for pre‐registration within the broader perspective of what good science is. We agree that there is potential benefit in a system of pre‐registration if implemented selectively. However, we believe that other tools of open science such as the full sharing of study materials and open access to underlying data, provide most of the same benefits—and more (i.e., the prevention of outright fraud)—without risking the potential adverse consequences of a system of pre‐registration. This is why we favor these other means of controlling type I error and fostering transparency. Direct replication, as opposed to conceptual replication, should be encouraged as well.     

Behavioral Functions of Aesthetics: Science and Art,Reason, and Emotion

The Psychological Record - In his landmark article for this journal, Francis Mechner (2017) presents a novel analysis of the confluence of unique combinations of variables accounting for aesthetic...     

Avoiding the Asymmetry Problem

If earlier‐than‐necessary death is bad because it deprives individuals of additional good life, then why isn't later‐than‐necessary conception bad for the same reason? Deprivationists have argued that prenatal non‐existence is not bad because it is impossible to be conceived earlier, but postmortem non‐existence is bad because it is possible to live longer. Call this the Impossibility Solution . In this paper, I demonstrate that the Impossibility Solution does not work by showing how it is possible to be conceived earlier in the same senses it is possible to live longer. I then offer a solution to the Asymmetry Problem by suggesting a novel way to separate the badness of each type of non‐existence from the type, and frequency, of attitudes we should have towards each type of non‐existence. Even if both types of non‐existence are equally bad, certain contingent facts about our postmortem non‐existence provide reason for the badness of early deaths to be more frequently salient than the badness of late conceptions. 1 1 For helpful discussion and feedback on earlier drafts of this paper, I am grateful to Kurt Blankschaen, Ben Bradley, Yishai Cohen, Jenni Ernst, John Martin Fischer, Frederik Kaufman, Gerald Marsh, Jeff McMahan, Hille Paakkunainen, Derek Parfit, Doug Portmore, Nate Sharadin, David Sobel, and my audience at the University of Miami. I am also greatly indebted to the anonymous referees who read this paper and whose detailed and insightful comments significantly improved the final product. Work on this paper was supported by the Immortality Project at the University of California Riverside, funded by the John Templeton Foundation.
     

Moral Obligations: Actualist,Possibilist, or Hybridist?

Do facts about what an agent would freely do in certain circumstances at least partly determine any of her moral obligations? Actualists answer ‘yes’, while possibilists answer ‘no’. We defend two novel hybrid accounts that are alternatives to actualism and possibilism: Dual Obligations Hybridism and Single Obligation Hybridism. By positing two moral ‘oughts’, each account retains the benefits of actualism and possibilism, yet is immune from the prima facie problems that face actualism and possibilism. We conclude by highlighting one substantive difference between our two hybrid accounts.     

Non-mereological pluralistic supersubstantivalism: an alternative perspective on the matter/spacetime relationship

In both the historical and contemporary literature on the metaphysics of space (and, more recently, spacetime), a core dispute is that between relationism and substantivalism. One version of the latter is supersubstantivalism, according to which space (or, again, spacetime) is the only kind of substance, such that what we think of as individual material objects (electrons, quarks, etc.) are actually just parts of spacetime which instantiate certain properties. If those parts are ontologically dependent on spacetime as a whole, then we arrive at an ontology with only a single genuinely independent substance, namely the entire spacetime manifold. This is monist supersubstantivalism. A view on which the parts of spacetime are ontologically prior to the whole has been called pluralistic supersubstantivalism. As currently formulated, supersubstantivalism (in either its monist or pluralistic forms) carries significant advantages and encounters major difficulties. I argue that some of the latter motivate an alternative formulation, non-mereological pluralistic supersubstantivalism, according to which spacetime is a real substance, but what we think of as material objects are also real substances, irreducible to and numerically distinct from that larger spacetime manifold and any of its parts. Yet, the underlying nature of those material objects is ultimately the same type as that of spacetime: at bottom, a particle is just a smaller quantity of spacetime embedded in or contained by or co-located with the larger whole that we would normally think of as ‘spacetime,’ capable both of genuine movement within/across the larger spacetime manifold and (at least in principle) independent existence from it.     

The relation of illness perceptions to stress,depression, and fatigue in patients with chronic lymphocytic leukaemia

Objective: Chronic lymphocytic leukaemia (CLL) is the most prevalent adult leukaemia and is incurable. The course and treatment of CLL is unique and characterised by repeated cycles of treatment, stable disease and relapse. Utilising a Self-Regulatory Model framework, we examined the relationship between patients’ illness perceptions and cancer-specific stress, depressive symptoms and fatigue. Our aim was to test illness perceptions as predictors of these outcomes when variance due to disease and treatment variables was controlled.

Design: Data were collected on 147 patients with relapsed/refractory CLL as they entered a phase II clinical trial of an investigational medication at a university affiliated, National Cancer Institute designated comprehensive cancer center.

Main outcome measures: Cancer-specific stress, depressive symptoms and fatigue interference.

Result:. Hierarchical multiple regression was used. Consequences and emotional representation were related to all outcomes (ps?p?p?Conclusion: Illness perceptions are related to cancer-specific stress, depressive symptoms and fatigue interference in relapsed/refractory CLL. Interventions targeted at restructuring maladaptive illness perceptions may have clinical benefit in this population.     

Effects of cognitive load on neural and behavioral responses to smoking-cue distractors

Smoking cessation failures are frequently thought to reflect poor top-down regulatory control over behavior. Previous studies have suggested that smoking cues occupy limited working memory resources, an effect that may contribute to difficulty achieving abstinence. Few studies have evaluated the effects of cognitive load on the ability to actively maintain information in the face of distracting smoking cues. For the present study, we adapted an fMRI probed recall task under low and high cognitive load with three distractor conditions: control, neutral images, or smoking-related images. Consistent with a limited-resource model of cue reactivity, we predicted that the performance of daily smokers (n = 17) would be most impaired when high load was paired with smoking distractors. The results demonstrated a main effect of load, with decreased accuracy under high, as compared to low, cognitive load. Surprisingly, an interaction revealed that the effect of load was weakest in the smoking cue distractor condition. Along with this behavioral effect, we observed significantly greater activation of the right inferior frontal gyrus (rIFG) in the low-load condition than in the high-load condition for trials containing smoking cue distractors. Furthermore, load-related changes in rIFG activation partially mediated the effects of load on task accuracy in the smoking-cue distractor condition. These findings are discussed in the context of prevailing cognitive and cue reactivity theories. These results suggest that high cognitive load does not necessarily make smokers more susceptible to interference from smoking-related stimuli, and that elevated load may even have a buffering effect in the presence of smoking cues under certain conditions.     

Do Unilateral Right and Left Face Contractions Induce Positive and Negative Emotions? A Further Test of Schiff and Lamon's (1989) Hypothesis

Schiff and Lamon (1989) proposed that unilateral face contractions induce positive or negative changes in emotion depending on the side of contraction; support for this proposal, however, has been mixed. In a new test, 40 right-handed and 38 left-handed men performed four alternating face contractions (LRLR or RLRL) and, after each one, completed a different version of the Depression Adjective Checklist (Lubin, 1994). A repeated-measures ANCOVA failed to reveal any significant effect of side of face contraction or handedness on direction of emotion change. Instead, regardless of side of contraction, the subjects' negative emotional state increased significantly across the four contractions with the degree of change being significantly related to the subjects' reported level of difficulty in holding the contraction irrespective of whether the more difficult side was the left or the right.     

Medication Administration By Family Members of Dependent Elders In Shared Care Arrangements

Twenty-three long-term care family caregivers whose care-recipients were enrolled in adult day care programs participated in face-to-face, semistructured interviews designed to learn more about their medication administration experiences. Two distinct styles of decision making were identified: self-directed and physician-directed. To help them with their medication administration responsibility, both groups used primary (physicians, pharmacists, or both) and secondary sources of information (the internet, information hotlines, nurses, more experienced caregivers, and family members with health backgrounds). Self-directed caregivers, who were significantly younger than the physician-directed caregivers, were twice as likely to report use of secondary sources of information to manage their medication administration tasks. Secondary sources of information appear to be important for the development of a caregiver's maturation and critical thinking skills over the long term and need more attention from formal providers in shared care relationships with family caregivers.