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The current knowledge about signaling networks is largely incomplete. Thus biologists constantly need to revise or extend existing knowledge. The revision and/or extension is first formulated as theoretical hypotheses, then verified experimentally. Many computer-aided systems have been developed to assist biologists in undertaking this challenge. The majority of the systems help in finding “patterns” in data and leave the reasoning to biologists. A few systems have tried to automate the reasoning process of hypothesis formation. These systems generate hypotheses from a knowledge base and given observations. A main drawback of these knowledge-based systems is the knowledge representation formalism they use. These formalisms are mostly monotonic and are now known to be not quite suitable for knowledge representation, especially in dealing with the inherently incomplete knowledge about signaling networks. We propose an action language based framework for hypothesis formation for signaling networks. We show that the hypothesis formation problem can be translated into an abduction problem. This translation facilitates the complexity analysis and an efficient implementation of our system. We illustrate the applicability of our system with an example of hypothesis formation in the signaling network of the p53 protein. 相似文献
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Bongki Woo Wen Fan Thanh Tran David Takeuchi 《American journal of community psychology》2020,65(1-2):78-89
Racial discrimination is known to harm health, but to what extent the health burden of racial discrimination is contingent on residential contexts is understudied. This study examines the moderating role of racial residential segregation in the relationship between racial discrimination and psychological distress. Nationally representative data from the 2002–2003 National Latino and Asian American Study were merged with metropolitan-level data from the U.S. Census. Logistic regression models were used to test the independent and joint contributions of racial discrimination and residential segregation to psychological distress among Asians and Latinxs, stratified by nativity status. Higher residential segregation (measured by the interaction index) is associated with lower odds of distress among U.S.-born Asians but not among other groups. As for the moderating effect, residential segregation exacerbates the positive association between discrimination and distress among foreign-born Asians (measured by the dissimilarity index) and foreign-born Latinxs (measured by the interaction index), but not among their respective U.S.-born counterparts. Taken together, the present study highlights that strategies to mitigate the psychological burden of racial discrimination need to move beyond individual-level efforts to incorporate neighborhood-based approaches. In particular, results provide empirical support for efforts to reduce residential segregation, particularly among immigrants who are discriminated against. 相似文献
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The Multicultural and Social Justice Counseling Competencies (MSJCC; Ratts, Singh, Nassar-McMillan, Butler, & McCullough, 2015) provide recommendations for social justice advocacy through a socioecological lens. The authors conceptualize and apply the MSJCC to inform counselor engagement in social justice advocacy for an often-neglected area of diversity: religion and/or spirituality. Practice and ethical examples, considerations, and recommendations related to religion and/or spirituality in MSJCC-compatible social justice advocacy are provided. 相似文献
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Martin Voracek Ulrich S. Tran Stefan G. Dressler 《Personality and individual differences》2010,48(1):72-77
Previously reported associations between low (male-typical) digit ratio (2D:4D), a putative pointer to prenatal testosterone exposure, and high (male-typical) sensation seeking have been inconsistent across studies (alternately present for men, women, either sex, or neither). Addressing this question again in three new studies (N = 198, 188, 1118) produced similarly erratic findings. Meta-analysis of the entire literature (13 studies with nearly 3000 individuals, including unpublished accounts) showed that the current cumulative evidence does not support any negative correlations between 2D:4D and sensation seeking traits. The only significant meta-analytical finding was for right-hand 2D:4D and the experience seeking facet of sensation seeking in both sexes, but this effect accounted for merely 0.4% attributable variance, and moreover was directionally opposite to expectation (i.e., a positive correlation). Discussed are inherent limitations of narrow-scoped approaches (such as via 2D:4D) for elucidating the biological bases of individual difference variables with evidentially intricate neurochemical underpinnings (such as sensation seeking). 相似文献
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Devon E. Hinton Steven A. Safren Mark H. Pollack Minh Tran 《Cognitive and behavioral practice》2006,13(4):271-281
For Vietnamese refugees, we describe (a) how headache- and orthostasis-focused panic attacks are generated, (b) a culturally sensitive treatment for PTSD with comorbid headache- and orthostasis-focused panic attacks, and (c) the outcome of a treatment series. In a multiple-baseline, across-subjects design (N = 3), all patients demonstrated treatment-related improvement of headache- and orthostasis-associated panic attacks; and in the repeated-measures, within-subjects design, all patients greatly improved across treatment on measures of psychopathology. One treatment case is presented. 相似文献
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By combining data from the 2011 Vietnam National Aging Survey and the 2011 Rural, Agricultural and Fishery Census, this study examined whether expenditure inequality has any effect on the quality of life (life satisfaction or happiness) among the elderly in rural Vietnam. It was confirmed from our regression analysis that individuals who live in the communes with high inequality tend to self-report as being less happy, even after controlling for various individual and household attributes. The findings are robust to the choice of inequality measures and the specification of econometric models. We also find that older rural people who are farmers or poor are more sensitive to inequality. Given that these people tend to be less happy than others, the result shows the risk that inequality further lowers their subjective well-being. This finding, in part, supports the view that rural Vietnam is not a mobile society. 相似文献
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Tran Tuyen Quang Nguyen Thanh Quy Van Vu Huong Doan Tinh Thanh 《Applied research in quality of life》2017,12(4):947-962
Applied Research in Quality of Life - Using data from the 2011 Vietnam National Aging Survey, we examined whether religion is associated with subjective well-being (i.e. happiness or life... 相似文献
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