Neurocognitive correlates of white matter quality in adolescent substance users

Background

Progressive myelination during adolescence implicates an increased vulnerability to neurotoxic substances and enduring neurocognitive consequences. This study examined the cognitive manifestations of altered white matter microstructure in chronic marijuana and alcohol-using (MJ + ALC) adolescents.

Methods

Thirty-six MJ + ALC adolescents (ages 16–19) and 36 demographically similar controls were evaluated with diffusion tensor imaging (Bava et al., 2009) and neurocognitive tests. Regions of group difference in fractional anisotropy (FA) and mean diffusivity (MD) were analyzed in relation to cognitive performance.

Results

In users, lower FA in temporal areas related to poorer performance on attention, working memory, and speeded processing tasks. Among regions where users had higher FA than controls, occipital FA was positively associated with working memory and complex visuomotor sequencing, whereas FA in anterior regions was negatively associated with verbal memory performance.

Conclusions

Findings suggest differential influences of white matter development on cognition in MJ + ALC using adolescents than in non-using peers. Neuroadaptation may reflect additive and subtractive responses to substance use that are complicated by competing maturational processes.     

What Studies of Actors and Acting Can Tell Us About Memory and Cognitive Functioning

ABSTRACT— The art of acting has been defined as the ability to live truthfully under imaginary circumstances. Our many years of researching theatrical expertise have produced findings relevant to text comprehension, learning theory, cognitive aging, and expert memory. In this article, we first discuss how large amounts of dialogue, learned in a very short period, can be reproduced in real time with complete spontaneity. We then turn to abstracting the essence of acting and applying it to diverse undertakings, from discovering optimal learning strategies to promoting healthy cognitive aging. Finally, we address the implications of acting expertise on current theories of embodied cognition.     

'Experiencing' Alpha: Finding and Embodying the Spirit and Being Transformed--Empowerment and Control in a ('Charismatic') Christian Worldview

This article analyses the Alpha Course, the 15-session evangelising programme designed by Holy Trinity Brompton. It argues that it is a popular form of evangelism influenced by the 'charismatic' movement, which aims to initiate participants into a particular religious 'experience'. It further argues that the course aims to stimulate participants to locate themselves, psychologically and socially, within a 'charismatic' worldview. The article aims to examine, phenomenologically, the Alpha 'experience', through an ethnographic analysis of the course and in particular its Holy Spirit weekend. The article relates Alpha to the wider beliefs and practices of the 'charismatic' movement and religious experience and assesses what it means for contemporary Christianity. It seeks to show that the initial 'experience' gained on the Alpha Course is continued within 'charismatic' experience in church meetings and services and looks at the personal empowerment and social control that may be at work.     

What makes interruptions disruptive? A study of length,similarity, and complexity

Summary Classic work on interruptions by Zeigarnik showed that tasks that were interrupted were more likely to be recalled after a delay than tasks that were not interrupted. Much of the literature on interruptions has been devoted to examining this effect, although more recently interruptions have been used to choose between competing designs for interfaces to complex devices. However, none of this work looks at what makes some interruptions disruptive and some not. This series of experiments uses a novel computer-based adventure-game methodology to investigate the effects of the length of the interruption, the similarity of the interruption to the main task, and the complexity of processing demanded by the interruption. It is concluded that subjects make use of some form of non-articulatory memory which is not affected by the length of the interruption. It is affected by processing similar material however, and by a complex mentalarithmetic task which makes large demands on working memory.     

Should We All be Scientists? Re-thinking Laboratory Research as a Calling

In recent years there have been major shifts in how the role of science—and scientists—are understood. The critical examination of scientific expertise within the field of Science and Technology Studies (STS) are increasingly eroding notions of the “otherness” of scientists. It would seem to suggest that anyone can be a scientist—when provided with the appropriate training and access to data. In contrast, however, ethnographic evidence from the scientific community tells a different story. Scientists are quick to recognize that not everyone can—or should—be a scientist. Appealing to notions such as “good hands” or “gut feelings”, scientists narrate a distinction between good and bad scientists that cannot be reduced to education, access, or opportunity. The key to good science requires scientists to express an intuitive feeling for their discipline, but also that individuals derive considerable personal satisfaction from their work. Discussing this personal joy in—and “fittingness” of—scientific occupations using the fields of STS, ethics and science policy is highly problematic. In this paper we turn to theology discourse to analyze the notion of “callings” as a means of understanding this issue. Callings highlight the identification and examination of individual talents to determine fit occupations for specific persons. Framing science as a calling represents a novel view of research that places the talents and dispositions of individuals and their relationship to the community at the center of flourishing practices.     

Face engagement during infancy predicts later face recognition ability in younger siblings of children with autism

Face recognition difficulties are frequently documented in children with autism spectrum disorders (ASD). It has been hypothesized that these difficulties result from a reduced interest in faces early in life, leading to decreased cortical specialization and atypical development of the neural circuitry for face processing. However, a recent study by our lab demonstrated that infants at increased familial risk for ASD, irrespective of their diagnostic status at 3 years, exhibit a clear orienting response to faces. The present study was conducted as a follow‐up on the same cohort to investigate how measures of early engagement with faces relate to face‐processing abilities later in life. We also investigated whether face recognition difficulties are specifically related to an ASD diagnosis, or whether they are present at a higher rate in all those at familial risk. At 3 years we found a reduced ability to recognize unfamiliar faces in the high‐risk group that was not specific to those children who received an ASD diagnosis, consistent with face recognition difficulties being an endophenotype of the disorder. Furthermore, we found that longer looking at faces at 7 months was associated with poorer performance on the face recognition task at 3 years in the high‐risk group. These findings suggest that longer looking at faces in infants at risk for ASD might reflect early face‐processing difficulties and predicts difficulties with recognizing faces later in life.     

Successful emotion regulation requires both conviction and skill: beliefs about the controllability of emotions,reappraisal, and regulation success

To succeed in self-regulation, people need to believe that it is possible to change behaviour and they also need to use effective means to enable such a change. We propose that this also applies to emotion regulation. In two studies, we found that people were most successful in emotion regulation, the more they believed emotions can be controlled and the more they used an effective emotion regulation strategy – namely, cognitive reappraisal. Cognitive reappraisal moderated the link between beliefs about the controllability of emotion and success in emotion regulation, when reappraisal was measured as a trait (Study 1) or manipulated (Study 2). Such moderation was found when examining the regulation of disgust elicited by emotion-inducing films (Study 1), and the regulation of anger elicited by real political events (Study 2). We discuss the implications of our findings for research and practice in emotion regulation.