Patients’ Views of Treatment-Focused Genetic Testing (TFGT): Some Lessons for the Mainstreaming of <Emphasis Type="Italic">BRCA1</Emphasis> and <Emphasis Type="Italic">BRCA2</Emphasis> Testing

This paper explores patients’ views and experiences of undergoing treatment-focused BRCA1 and BRCA2 genetic testing (TFGT), either offered following triaging to clinical genetics (breast cancer) or as part of a mainstreamed care pathway in oncology (ovarian cancer). Drawing on 26 in-depth interviews with patients with breast or ovarian cancer who had undergone TFGT, this retrospective study examines patients’ views of genetic testing at this point in their care pathway, focusing on issues, such as initial response to the offer of testing, motivations for undergoing testing, and views on care pathways. Patients were amenable to the incorporation of TFGT at an early stage in their cancer care irrespective of (any) prior anticipation of having a genetic test or family history. While patients were glad to have been offered TFGT as part of their care, some questioned the logic of the test’s timing in relation to their cancer treatment. Crucially, patients appeared unable to disentangle the treatment role of TFGT from its preventative function for self and other family members, suggesting that some may undergo TFGT to obtain information for others rather than for self.     

Adjustment Profiles of Low-Income Caregivers from the United States and South Africa: Contrasts and Commonalities

Although low-income parents living in under-resourced communities in the United States and around the world face challenges, many do well while others struggle in one or more areas of functioning. The present study examined patterns of adjustment among maternal caregivers living in the United States (US) (N?=?320) and South Africa (SA) (N?=?324). Cluster analyses across four domains of functioning representing both positive and negative adjustment and conducted within country revealed similar patterns of adjustment, with a majority of caregivers (37.8% in the US; 47.5% in SA) landing in a “holding steady” pattern, exhibiting good but not exceptional adjustment. Other patterns of adjustment (three additional in the US sample; two additional in the SA sample) showed elevated impairment in somatic complaints, problems with alcohol, or life satisfaction. In both the US and SA, support from family, friends, and neighbors differentiated the adjustment profiles. Further, both current stressors within and outside of the family and previous stressors including direct and indirect exposure to violence discriminated caregivers who were “holding steady” from those who were struggling in one or more domains. Additionally, across both countries, caregivers who were “holding steady” evidenced less avoidant coping. Implications of this work for fostering resilience among caregivers and their children are discussed.     

Understanding the Association Between Spirituality,Religiosity, and Feelings of Happiness and Sadness Among HIV-Positive Indian Adults: Examining Stress-Related Growth as a Mediator

This study examined the role of stress-related growth as a mediator of the associations between spirituality, religiosity, and feelings of happiness and sadness in a sample of 178 HIV-positive Indian adults. Results indicated that spirituality, but not religiosity, was associated with feelings of happiness and sadness. Subsequent mediation analyses indicated that stress-related growth fully mediated the relationships involving spirituality and feelings of happiness and sadness. Overall, our findings point to the importance of facilitating greater spiritual development among HIV-positive Indians, as well as promoting strategies that help them develop and apply stress-related growth coping methods in their lives.     

Testing complex animal cognition: Concept learning,proactive interference,and list memory

This article describes an approach for assessing and comparing complex cognition in rhesus monkeys and pigeons by training them in a sequence of synergistic tasks, each yielding a whole function for enhanced comparisons. These species were trained in similar same/different tasks with expanding training sets (8, 16, 32, 64, 128 … 1024 pictures) followed by novel‐stimulus transfer eventually resulting in full abstract‐concept learning. Concept‐learning functions revealed better rhesus transfer throughout and full concept learning at the 128 set, versus pigeons at the 256 set. They were then tested in delayed same/different tasks for proactive interference by inserting occasional tests within trial‐unique sessions where the test stimulus matched a previous sample stimulus (1, 2, 4, 8, 16 trials prior). Proactive‐interference functions revealed time‐based interference for pigeons (1, 10 s delays), but event‐based interference for rhesus (no effect of 1, 10, 20 s delays). They were then tested in list‐memory tasks by expanding the sample to four samples in trial‐unique sessions (minimizing proactive interference). The four‐item, list‐memory functions revealed strong recency memory at short delays, gradually changing to strong primacy memory at long delays over 30 s for rhesus, and 10 s for pigeons. Other species comparisons and future directions are discussed.     

The dimensions of deception detection: Self‐reported deception cue use is underpinned by two broad factors

Many perceived cues to deception have been reported in the literature, but little attention has been paid to how they are combined when making deception judgments. The present research used a data‐driven approach to investigate how cues are integrated when evaluating veracity. Two hundred fifteen participants performed a deception detection task before completing a deception cue use questionnaire. A factor analysis of the questionnaire data produced two dimensions, one associated with nonverbal cues to anxiety and the other associated with detail and level of involvement. The present work extends our understanding of deception detection processes and underlines the importance of examining not only the cues that people use but also the way in which they use them.     

On Argumentation Logic and Propositional Logic

This paper studies the relationship between Argumentation Logic (AL), a recently defined logic based on the study of argumentation in AI, and classical Propositional Logic (PL). In particular, it shows that AL and PL are logically equivalent in that they have the same entailment relation from any given classically consistent theory. This equivalence follows from a correspondence between the non-acceptability of (arguments for) sentences in AL and Natural Deduction (ND) proofs of the complement of these sentences. The proof of this equivalence uses a restricted form of ND proofs, where hypotheses in the application of the Reductio of Absurdum inference rule are required to be “relevant” to the absurdity derived in the rule. The paper also discusses how the argumentative re-interpretation of PL could help control the application of ex-falso quodlibet in the presence of inconsistencies.     

Measurement and Predictive Invariance of a Work–Life Boundary Measure Across Gender

Pervasive gender norms influence the way in which men and women create and experience work–life boundaries and work–life conflict, which may lead to differing conceptions of work–life boundary management. Measurement equivalence/invariance (ME/I) and predictive invariance analyses were conducted on the WorkLife Indicator^TM (WLI), a measure of work–life boundary management, to determine if men and women maintain similar conceptualizations of work–life boundary constructs and if work–life outcomes are predicted equally well by WLI scales across gender. Three of the five WLI scales exhibited ME/I; however, half of the WLI scale–criterion pairings failed to demonstrate predictive invariance. These results indicate that measurement and/or predictive invariance cannot be assumed when using work–life boundary assessments across gender.     

The number line effect reflects top-down control

Recent evidence indicates that central directional stimuli, such as eyes and arrows, trigger rapid, reflexive shifts of spatial attention. A study by Fischer, Castel, Dodd, and Pratt (2003) suggested that a similar effect might also apply to central numbers, as if a digit's meaning causes attention to be oriented to its relative position on a left-to-right mental number line. However, unlike central eyes and arrows, the orienting effect for central digits emerges slowly, suggesting that top-down endogenous processes may be mediating this effect. Here, we report a series of three experiments that strongly support this hypothesis. Experiment 1 replicated Fischer et al.'s left-to-right number line effect. Experiment 2 showed that this effect could be completely reversed by merely asking participants to imagine a number line running from right to left. Experiment 3 showed that a left-to-right number line effect could be abolished by presenting targets above and below central fixation, as well as to the left and right of center. Experiment 3 also showed that other mental sets, such as imagining a clock, result in attention's being oriented in accordance with where the central digits are represented on a clock face. Together, these data indicate that the spatial representations and attentional orienting related to the perception of digits are both fragile and flexible and depend critically on the top-down spatial mental sets adopted by individuals.