内表型方法在精神疾病研究中的应用

精神疾病在很大程度上受到遗传的影响,而对疾病的遗传学研究却没有得到一致的结论,内表型正是在这一背景下提出。内表型是可以通过生化测试或显微镜检查发现的内在的表现型,即内表型不是很明显的、外在的而是微观的、内在的,内表型比疾病的外在表现更接近疾病的生物学基础,更少受到外在因素的影响,因而通过内表型来研究疾病的遗传基因有着显著的优势。现有的精神疾病诊断和分类标准都是以临床症状和行为描述为基础的,缺少生物学基础,基于内表型的分析对建立疾病的诊断和分类的生物学基础是非常重要的。内表型可以是神经生理的,生物化学的,神经解剖的,认知的,神经心理学的测量。作为内表型需要满足与疾病共同存在,可遗传,状态独立,在家庭中和疾病共分离,在病人未发病亲属中比一般人群的比率要高等标准。该文在介绍了内表型的概念,说明了内表型的原理,优点与用处,以及作为内表型需要满足的标准之后,进而以几种常见的精神疾病（多动症、精神分裂症、抑郁症）为例说明了目前认知内表型研究的进展,其中反应抑制和工作记忆可以作为多动症的内表型,注意、言语记忆和工作记忆可以作为精神分裂症和抑郁症的内表型,文章回顾了它们作为内表型所满足的标准的相关文献。最后对内表型的研究做出了展望     

False memories are hard to inhibit: differential effects of directed forgetting on accurate and false recall in the DRM procedure

Directed forgetting research shows that people can inhibit the retrieval of words that they were previously instructed to forget. The present research applied the directed forgetting procedure to the Deese/Roediger and McDermott (DRM) recall task to determine if directed forgetting instructions have similar or different effects on accurate and false memory. After studying lists of semantically related words, some participants were told to forget those lists, whereas other participants were not. All participants were then shown additional lists to remember. Following study, all participants were asked to free recall as many of the studied words as possible, including those they were previously instructed to forget. Directed forgetting instructions inhibited the accurate recall of studied words, but not the false recall of nonstudied critical words, whether measured by a within-participant or between-participants design. Contrary to an implicit activation hypothesis, false memories survived instructions to forget. These findings were reviewed in terms of fuzzy trace theory and the activation/monitoring approach to false memory.     

On Aristotelianism and Structures as Parts

Aristotelian substance theory tells us that substances have structures (read: forms) as proper parts. This claim has recently been defended by Kathrin Koslicki who dubbed it the ‘Neo‐Aristotelian Thesis.’ Strangely, Aristotelianism has not yet been universally embraced by philosophers – partly because some of its claims, such as the Neo‐Aristotelian Thesis – are viewed by some as counterintuitive at best. In this paper, I argue for Aristotelianism by showing its philosophical usefulness: specifically, I put it to use in saving the metaphysical doctrine of endurantism and some central mereological doctrines (such as Transitivity) from recent attacks. This utility gives us reason to endorse Aristotelianism. Along the way, I defend Koslicki's argument for the Neo‐Aristotelian Thesis from a recent criticism, thus helping provide still more reason to endorse Aristotelianism: namely, Koslicki's vindicated argument.     

The Full Unity of the Virtues

The classical doctrine that the moral virtues are unified is widely rejected. Some argue that the virtues are disunified, or even mutually incompatible. And though others have argued that the virtues form some sort of unity, these recent defenses of unity are always qualified, advocating only a partial unity: the unity of the virtues is limited to certain practical domains, or weak in that one virtue implies only moral decency in the fields of other virtues. I argue that something like the classical doctrine—a full unity of the virtues thesis—remains defensible. After reviewing the arguments of partial unity theorists for the claim that the virtues form at least some sort of unity, I examine their main arguments for thinking that this unity is only partial (limited or weak). I then show that these arguments fail, and address some further criticisms (such as the argument that full unity implausibly requires that a person must attain the virtues “all at once”). I do not seek here to prove the truth of the full unity thesis (in fact I suggest a modification of it), but only to refute important extant criticisms of it, and thus to show that it remains a plausible view.     

Hylemorphic animalism

Roughly, animalism is the doctrine that each of us is identical with an organism. This paper explains and defends a hylemorphic version of animalism. I show how hylemorphic animalism handles standard objections to animalism in compelling ways. I also show what the costs of endorsing hylemorphic animalism are. The paper’s contention is that despite the costs, the view is worth taking seriously.     

Vision-fair neuropsychological assessment in normal aging, Parkinson's disease and Alzheimer's disease

We examined performance of healthy older and younger adults and individuals with Alzheimer's disease (AD) and Parkinson's disease (PD) on digit cancellation, a task putatively sensitive to cognitive impairment, but possibly affected by visual impairment, particularly in contrast sensitivity. Critical contrast thresholds were established to create custom stimulus arrays that were proximally matched across individuals. Age- and PD-related differences in search were fully accounted for by the sensory deficit. Increased contrast benefited AD patients, but could not override cognitive impairment. We conclude that visually fair neuropsychological testing can effectively compensate for normal age- and PD-related visual changes that affect cognitive performance. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Symptoms of Depression Among Caribbean Women and Caribbean-Canadian Women

This study compared an immigrant sample of Caribbean-Canadian women ( n = 20) and a sample of women living in the Caribbean ( n = 20) on the following variables: dominant domain of meaning (defined as that aspect of the participant's life from which she derives primary meaning for her sense of self); self-silencing (defined as the tendency to silence one's thoughts and feelings; Jack, 1991); and symptoms of depression. Results revealed that the Caribbean women were more likely to report relational domains of meaning as primary ( e.g. , family, friendships, intimate relationships), while the Caribbean-Canadian women were more likely to report domain of self-nurturance as primary ( e.g. , career goals, spirituality). Furthermore, univariate analysis revealed that the Caribbean-Canadian women reported higher levels of self-silencing and depressive symptoms, and derived less meaningfulness from their primary domains of meaning compared to the Caribbean women. These findings suggest that the immigrant experience may be a factor in women's emotional well-being.