Conditioned placebo responses

Following earlier animal research, we attempt to condition placebo effects in human subjects. Four groups of 8 voluntary subjects were told that the experimenters would test a powerful new analgesic cream over three sessions by assessing its ability to reduce experimentally induced pain. The analgesic cream was, in fact, a placebo. In the first session all subjects were tested with and without the cream to assess their placebo response. In the second session, to condition two groups (with differing stimulation levels) to experience pain relief in response to the placebo, we repeatedly paired a reduction in nocioceptive stimulation with placebo administration. (Subjects were unaware that stimulation levels were manipulated). To condition the other two groups (with different stimulation levels) to experience an exacerbation of the pain, we paired an increase in nocioceptive stimulation with placebo administration. In the third session, all subjects were again tested for placebo response. Results suggested that placebo responses are conditionable in the laboratory in both a positive and negative direction. The clinical implications of a learning theory of placebo behavior are discussed.     

Test anxiety and visual vigilance

Twenty male and 20 female subjects, previously classified as high or low in test anxiety, participated in an experiment on visual vigilance under conditions designed either to enhance or minimize feelings of being tested. Detection rate declined across the 36 min of the task among subjects high in test anxiety who believed that they were being tested and in subjects low in test anxiety who did not. False detection rates revealed no significant differences among conditions. Analysis of sensitivity to signals according to statistical decision theory revealed low sensitivity in both the high-anxiety test and low-anxiety/no-test conditions than in the other two. Analysis of decisional criteria showed that subjects in the high-anxiety test condition were more conservative in setting a criterion than subjects in the other three conditions. No sex differences were found. The results are discussed in terms of an elaboration of Sarason's (1978) model of test anxiety.     

Correspondence analysis used complementary to loglinear analysis

Loglinear analysis and correspondence analysis provide us with two different methods for the decomposition of contingency tables. In this paper we will show that there are cases in which these two techniques can be used complementary to each other. More specifically, we will show that often correspondence analysis can be viewed as providing a decomposition of the difference between two matrices, each following a specific loglinear model. Therefore, in these cases the correspondence analysis solution can be interpreted in terms of the difference between these loglinear models. A generalization of correspondence analysis, recently proposed by Escofier, will also be discussed. With this decomposition, which includes classical correspondence analysis as a special case, it is possible to use correspondence analysis complementary to loglinear analysis in more instances than those described for classical correspondence analysis. In this context correspondence analysis is used for the decomposition of the residuals of specific restricted loglinear models.     

Iterative least squares estimates of communality: Initial estimate need not affect stabilized value

A common criticism of iterative least squares estimates of communality is that method of initial estimation may influence stabilized values. As little systematic research on this topic has been performed, the criticism appears to be based on cumulated experience with empirical data sets. In the present paper, two studies are reported in which four types of initial estimate (unities, squared multiple correlations, highestr, and zeroes) and four levels of convergence criterion were employed using four widely available computer packages (BMDP, SAS, SPSS, and SOUPAC). The results suggest that initial estimates have no effect on stabilized communality estimates when a stringent criterion for convergence is used, whereas initial estimates appear to affect stabilized values employing rather gross convergence criteria. There were no differences among the four computer packages for matrices without Heywood cases.     

Antidepressant treatment of children: clinical relapse is unrelated to tricyclic plasma concentrations

Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.