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41.
Children and individuals with developmental disabilities (DD) compared to typical participants are disadvantaged not only by virtue of being vulnerable to risks inherent in research participation but also by the higher likelihood of exclusion from research altogether. Current regulatory and ethical guidelines although necessary for their protection do not sufficiently ensure fair distributive justice. Yet, in view of disproportionately higher burdens of co-occurring physical and mental disorders in individuals with DD, they are better positioned to benefit from research by equitable participation. Greater elucidation of this ethical dilemma is called for by researchers, institutional review boards, and funding agencies to urgently redress the imbalance. This article discusses many of the regulatory principles to ensure better research participation of children and individuals with DD: human rights, validity, distributive justice, beneficence/nonmaleficence, and autonomy. 相似文献
42.
Yago E Duarte A Wong T Barceló F Knight RT 《Cognitive, affective & behavioral neuroscience》2004,4(4):609-617
Single-unit, event-related potential (ERP), and neuroimaging studies have implicated the prefrontal cortex (PFC) in top-down
control of attention and working memory. We conducted an experiment in patients with unilateral PFC damage (n=8) to assess the temporal kinetics of PFC-extrastriate interactions during visual attention. Subjects alternated attention
between the left and the right hemifields in successive runs while they detected target stimuli embedded in streams of repetitive
task-irrelevant stimuli (standards). The design enabled us to examine tonic (spatial selection) and phasic (feature selection)
PFC-extrastriate interactions. PFC damage impaired performance in the visual field contralateral to lesions, as manifested
by both larger reaction times and error rates. Assessment of the extrastriate P1 ERP revealed that the PFC exerts a tonic
(spatial selection) excitatory input to the ipsilateral extrastriate cortex as early as 100 msec post stimulus delivery. The
PFC exerts a second phasic (feature selection) excitatory extrastriate modulation from 180 to 300 msec, as evidenced by reductions
in selection negativity after damage. Finally, reductions of the N2 ERP to target stimuli supports the notion that the PFC
exerts a third phasic (target selection) signal necessary for successful template matching during postselection analysis of
target features. The results provide electrophysiological evidence of three distinct tonic and phasic PFC inputs to the extrastriate
cortex in the initial few hundred milliseconds of stimulus processing. Damage to this network appears to underlie the pervasive
deficits in attention observed in patients with prefrontal lesions. 相似文献
43.
44.
能够代表汉代200余年历史进程的性习心理思想的主要观点可以概括为:《淮南子》的“循天返朴说”、董仲舒的“性待教为善说”和王充的“性有善恶,教可异化说”。这些观点不仅在当时能够集时代之大成,就是今天,对现代心理学研究仍有启发和借鉴的价值。 相似文献
45.
定量运动负荷后间隔不同时间的肘关节动觉方位准确性 总被引:10,自引:0,他引:10
该研究以过去研究中发现的定量运动负荷可以显著提高肘关节动觉方位准确性为基础,试图讨论这种定量运动负荷后间隔不同时间的肘关节动觉方位准确性。 相似文献
46.
Found in Translation: Late Bilinguals Do Automatically Activate Their Native Language When They Are Not Using It 下载免费PDF全文
In their paper “Do Bilinguals Automatically Activate Their Native Language When They Are Not Using it?”, Costa, Pannunzi, Deco, and Pickering (Cognitive Science, 2017) proposed a reinterpretation of Thierry and Wu's (2004, 2007) finding of native language‐based (Chinese, L1) ERP effects when they tested Chinese–English late bilinguals exclusively in their second language (English, L2). Using simulations in a six‐node Hebbian learning model (three L1 nodes, three L2 nodes), Costa et al. suggested that form overlaps in L1 between otherwise unrelated words create a persistent relationship between their L2 translations. In this scenario, words in the nascent L2 lexicon overlapping in their L1 translations would become linked during learning because of the form overlap in L1; once the L2 words are learned, the direct link between them would be sufficient to generate robust, apparently “L1‐mediated” priming without requiring any activation of L1 translations. Costa et al. contend that links between L2 words remain beyond the learning phase, even after links to L1 representations have been severed, and thus that their model affords an alternative account to (but not a rebuttal of) Thierry and Wu's claim of language non‐selective activation—or automatic activation of translation equivalents—in late bilinguals. In this response, we build on Costa et al.'s original simulation code, showing that it can only reproduce L1‐independent priming when implementing the L1 disconnection in their particular way. By contrast, when severing inter‐language connections bidirectionally, their model fails to retain any sizeable influence of L1 form overlap on L2 activations. The model is not the theory, however, and we discuss several issues that would need to be addressed in further attempts to model language non‐selective activation in late bilinguals. 相似文献
47.
本文针对1例伴心脑血管疾病的老年患者行半髋关节置换术的麻醉方案进行循证分析.首先,笔者评估该患者术前的生理情况,对围术期可能出现的棘手问题进行预测.然后,针对如何科学地看待上述问题,进行证据检索和评价.最后,根据循证依据为该患者选择理想的麻醉方式. 相似文献
48.
CD147属于免疫球蛋白超家族的跨膜糖蛋白,在多种细胞表面均有表达,在生殖、机体发育、免疫功能中发挥重要作用,还参与了肿瘤浸润转移等多种病理过程,由于其在多种肿瘤细胞表面高表达,而且与肿瘤的恶性程度相关,目前已成为研究肿瘤浸润与复发的热点. 相似文献
49.
焦虑抑郁不仅是高血压的促发因素,也是影响高血压发生及预后的不良因素之一.抗焦虑抑郁治疗不仅可以有效消除高血压患者焦虑抑郁的情绪,还可以减少降压药的用药剂量,增强降压药的疗效,而且明显改善高血压患者的预后,降低心脑血管事件的发生率.现就有关焦虑抑郁和高血压的研究进展做一综述. 相似文献
50.