NR3C1基因多态性及单倍型、父母教养方式对青少年焦虑障碍的影响

NR3C1参与HPA轴调节,与应激相关的身心疾病关系密切。以往针对NR3C1与焦虑障碍的研究基本以成人为考察对象,且大多关注负性生活事件等个体层面环境变量。本研究采用病例-对照设计,以238名青少年为被试(焦虑障碍117人,对照121人),旨在考察NR3C1常见位点rs6191、rs6196、rs41423247的多态性、单倍型以及父母不同类型教养方式对焦虑障碍的影响。结果表明rs6191 GG基因型、rs6196 AA基因型、rs41423247 GG基因型与低焦虑障碍风险相关。父母过多的过度保护与冷漠拒绝、父亲过少的温暖关怀可预测较高的焦虑障碍风险。rs41423247多态性与母亲温暖关怀存在交互作用:rs41423247 GG基因型只在母亲温暖关怀较多时能降低焦虑障碍风险,在母亲温暖关怀较少时与焦虑障碍并无显著相关。此外,rs6191-rs6196-rs41423247构成的单倍型GAG与低焦虑障碍风险显著关联,TGC与高焦虑障碍风险显著关联,且二者与母亲温暖关怀、母亲过度保护分别存在交互作用。未来可采用追踪研究,从表观遗传层面探讨教养方式与NR3C1影响焦虑障碍的内在机制。     

“各说各话”的语言经验对景颇族大学生执行功能的影响

在中国云南的景颇族中,相当多的家庭是由不同支系的人组成的,家庭成员交际时存在着"各说各话"的现象。"各说各话"对讲话者的执行功能有无影响?采用抑制控制、注意转换和记忆刷新任务测量各说各话和非各说各话的景颇族大学生的抑制能力、转换能力和刷新能力。结果表明,各说各话与非各说各话的景颇族大学生在色词干扰和数字转换中差异显著,各说各话者的Stroop效应量小,停止信号的反应时短。各说各话与非各说各话的景颇族大学生在数字转换和图形转换中差异显著,各说各话者反应快,转换代价小。各说各话与非各说各话的景颇族大学生在活动记忆刷新与色点位置刷新任务中差异不显著。这表明,各说各话者比非各说各话者在抑制能力与转换能力上具有优势。语言经验对执行功能的影响具有功能特异性。     

Older children's misunderstanding of uncertain belief after passing the false belief test

A four-location belief task was designed to examine children's understanding of another's uncertain belief after passing a false belief (FB) task. In Experiment 1, after passing the FB task, participants were asked what a puppet would do after he failed to find his toy at the falsely believed location. Most 4-year-olds and half of 6-year-olds children who passed the FB test showed difficulty in handling uncertain belief; answering that the puppet would then look for his toy at the current (moved-to) location. Eight-year-old children and adults all recognized that the puppet would look for the toy everywhere, or at random. In Experiment 2, 4- and 6-year-olds were presented two other search tasks; it was shown that preschoolers could use search strategies to solve a similar search problem when FB was not involved. This new aspect of post-FB understanding can be interpreted in terms of limited understanding of uncertainty in a less-knowledgeable individual and of limited ability to infer the consequences of belief-disconfirmation.     

Family Microtransitions: Observing the Process of Change in Families with Adolescent Children

To read this article in Spanish, please see this article's Supporting Information on Wiley InterScience (http://interscience.wiley.com/journal/famp). To read this article's abstract in both Spanish and Mandarin Chinese, please visit the article's full‐text page on Wiley InterScience ( http://interscience.wiley.com/journal/famp ). The aim of the study is to explore the process of microtransitions in families with adolescent children. Original methodological procedures were designed in order to have families as the objects of study and to analyze data with particular attention to the family process of change. A family interview focused on the adolescent and family change was conducted with 12 families having an adolescent child. As indicators of change, we used coordination and oscillation. Our results highlight different patterns of family interactions, illustrating various ways through which families deal with change. Conclusive remarks focus on the theoretical relevance of the study, the method and the implications for family practice and policy.     

Building Kinship and Community: Relational Processes of Bicultural Identity Among Adult Multiracial Adoptees

To read this article's abstract in both Spanish and Mandarin Chinese, please visit the article's full-text page on Wiley InterScience ( http://interscience.wiley.com/journal/famp ).
This study uses the case of transracially adopted multiracial adults to highlight an alternative family context and thus process of African American enculturation. Interpretive analyses of interviews with 25 adult multiracial adoptees produced 4 patterns in their bicultural identity formation: (1) claiming whiteness culturally but not racially, (2) learning to "be Black"—peers as agents of enculturation, (3) biological pathways to authentic Black kinship, and (4) bicultural kinship beyond Black and White. Conceptualizing race as an ascribed extended kinship network and using notions of "groundedness" from bicultural identity literature, the relational aspects of participants' identity development are highlighted. Culturally relevant concepts of bicultural identity are proposed for practice with multiracial adoptees who have multiple cultures of origin and for whom White mainstream culture is transmitted intrafamilially as a first culture.     

一般流体智力的结构与老化机制--结构方程模型的比较

近年来一般流体智力的认知结构与老化机制已成为认知研究中的一个热点。本研究通过结构方程模型探讨了认知加工速度、工作记忆、注意能力与一般流体智力的联系,结果表明：加工速度、控制性注意是一般流体智力的主要认知成分,工作记忆并非一般流体智力的认知成分,两者之间足共变关系。加入年龄因子的结构方程模型也证实了加工速度和控制性注意是一般流体智力老化的重要中介因子。     

大学生宿舍人际关系与抑郁的关系:宿舍冲突应对方式的中介作用和性别的调节作用

本研究使用宿舍人际关系问卷、抑郁自评量表和宿舍冲突应对方式问卷,采取整群随机抽样的方法,从武汉市三所大学抽取了876名大一至大四的本科生进行调查,旨在考察宿舍冲突应对方式在大学生宿舍人际关系与抑郁之间的中介作用以及性别的调节作用。结果表明：（1）宿舍人际关系与抑郁显著负相关;宿舍冲突应对方式中的竞争、回避与抑郁显著正相关,合作与抑郁显著负相关;（2）竞争与合作在大学生宿舍人际关系与抑郁之间中介效应显著;（3）性别调节了宿舍人际关系通过竞争影响抑郁的中介过程的前半段路径。本研究以宿舍人际关系和宿舍冲突应对方式为切入点考察它们对抑郁的影响机制,这为预防和干预大学生抑郁提供了新的视角。     

丰富环境对脑缺血大鼠突触界面结构修饰和PSD-95基因表达的影响

探讨丰富环境干预对局部脑缺血大鼠突触界面结构修饰和突触后致密物-95 (postsynaptic density-95,PSD-95 ) mRNA表达的影响。栓塞健康雄性Sprague-Dawley大鼠的右侧大脑中动脉,建立脑中动脉栓塞(middle cerebral artery occlusion,MCAO)模型后,分为丰富环境缺血组(IE)、标准环境缺血组(IS),同时分别设丰富环境假手术组(SE)、标准环境假手术组(SS)。以Morris水迷宫检测大鼠的空间学习记忆能力,应用透射电镜、图像分析和细胞形态计量学技术,观察海马CA1区和额叶皮层突触界面结构变化,采用RT-PCR检测突触后脚手架蛋白PSD-95 mRNA的表达。结果表明：丰富环境干预能有效改善脑缺血导致的空间学习记忆能力下降,并对正常大鼠的空间学习记忆能力也有改善作用。同时,丰富环境干预能抑制局部脑缺血导致的突触数密度减少,该作用对额叶皮层特别明显;丰富环境干预不同程度地逆转脑缺血造成的突触界面参数变化,特别使突触间隙宽度显著减小、PSD厚度明显增加;并有效抑制因脑缺血诱导的PSD-95 mRNA表达下调。以上结果提示,丰富环境改善脑缺血大鼠的空间学习记忆能力可能与其促进缺血区边缘组织突触界面结构修饰,提高PSD-95 mRNA表达有关     

妊娠期肝内胆汁淤积症研究中的认识论

妊娠期肝内胆汁淤积症是一种常见的妊娠晚期并发症,临床上以皮肤瘙痒和黄疸为特征,伴有胆汁酸、肝酶等生化指标的异常。其对母体影响较小,但可以引起早产、胎窘和不明原因的死胎,对围生儿的严重危害使其受到了产科医生的重视。因此,有必要通过回顾妊娠期肝内胆汁淤积症的认识过程来看医学认识发展中所体现的哲学观点。