疼痛恐惧相关的注意偏向及其矫正

疼痛恐惧是影响和维持慢性痛的重要因素。不同材料和被试类型情况下, 疼痛恐惧均主要作用于个体对疼痛相关信息的早期注意加工阶段, 表现为注意警觉模式。该注意模式使个体将注意维持在疼痛上, 从而干扰了对非疼信息的注意能力。矫正疼痛恐惧相关注意偏向可以改善疼痛体验。未来研究应采用更具生态效度的任务测量疼痛恐惧相关的注意偏向及其神经基础, 进一步考察矫正疼痛恐惧相关注意偏向能否改善慢痛患者的忧郁和功能丧失等问题。     

面孔识别特异性本质的ERP研究

本研究记录了16名被试在完成有整体结构变化和局部特征变化的面孔/房屋图片的一致性判断时的脑内时程变化,以期对面孔识别的特异性本质进行探讨。结果显示,N170波幅和潜伏期的刺激类型主效应显著;面孔/房屋所诱发的N170成分在波幅和潜伏期上均不存在加工方式上的显著差异。晚期成分(300～700ms)上也得到类似的结果。这表明:面孔与房屋(非面孔)的加工在早期和晚期成分上都有差异性,体现出面孔的加工在早期视觉刺激的加工和晚期识别的加工上都具有特异性;晚期识别加工的脑电结果不支持"面孔识别是整体的,结构的,而非面孔客体的识别是局部的,基于特征的"加工观点。     

Insufficient augmentation of ambient GABA responsible for age-related cognitive deficit

Age-related degeneration of intracortical inhibition could underlie declines in cognitive function during senescence. Based on a hypothesis that a decrease in basal concentration of ambient (extrasynaptic) GABA with aging leads to depressing intracortical inhibition, we investigated how the basal concentration affects stimulus-evoked activity (as signal), ongoing-spontaneous activity (as noise) of neurons and their (signal-to-noise) ratio S/N. We simulated a neural network model equipped with a GABA transport system that regulates ambient GABA concentration in a neuronal activity-dependent manner. An increase in basal concentration augmented ambient GABA, increased GABA-mediated inhibitory current, and depressed ongoing-spontaneous activity while still keeping stimulus-evoked activity. This led to S/N improvement, for which it was necessary for the reversal potential of GABA transporter to be close to the resting potential of neurons. Above the resting potential, ongoing-spontaneous activity was predominantly enhanced due to excessive GABA-uptake from the extracellular space by transporters. Below the resting potential, stimulus-evoked activity was predominantly depressed, caused by excessive GABA-release. We suggest that the insufficient augmentation of ambient GABA due to a decrease in its basal concentration may be one of the possible causes of cognitive deficit with aging, increasing ongoing-spontaneous neuronal activity as noise. GABA transporter may contribute to improving S/N, provided that its reversal potential is close to the resting potential.     

天镇盘山显化寺

<正>大同天镇县城东南行8里,在重峦迭嶂中隐藏着一座古刹——闻名遐迩的盘山显化寺,俗称"盘山寺"、"盆山寺"、"盘山显化寺"。显化寺始建于明宣德二年(1427),明嘉靖年间、万历年间、清康熙年间、光绪年间均有修缮。初建时为佛寺,清代时形成释、道、儒三教合一的寺院。     

护理执行用药医嘱的伦理学思考

护理人员在医疗机构推行临床合理用药的过程中承担着十分重要的任务。加强护理人员的道德教育,提高护理人员的素质,提高药物使用业务知识水平,提高与药物临床使用相关的护理技能,真正体现医疗机构推行的"以人为本"的护理理念,为患者的健康、康复负责。     

中药在心血管疾病中应用现状与反思

具有悠久历史的中医药在现代医学中有鲜明的时代特点。心血管疾病是现代社会严重威胁生命及健康的病患。本文总结分析了古老中药在现代心血管疾病中应用的现状,并深入分析其影响因素,从而提出扬长避短的未来心血管疾病应用中药的思路。     

Subjective value of risky foods for individual domestic chicks: a hierarchical Bayesian model

For animals to decide which prey to attack, the gain and delay of the food item must be integrated in a value function. However, the subjective value is not obtained by expected profitability when it is accompanied by risk. To estimate the subjective value, we examined choices in a cross-shaped maze with two colored feeders in domestic chicks. When tested by a reversal in food amount or delay, chicks changed choices similarly in both conditions (experiment 1). We therefore examined risk sensitivity for amount and delay (experiment 2) by supplying one feeder with food of fixed profitability and the alternative feeder with high- or low-profitability food at equal probability. Profitability varied in amount (groups 1 and 2 at high and low variance) or in delay (group 3). To find the equilibrium, the amount (groups 1 and 2) or delay (group 3) of the food in the fixed feeder was adjusted in a total of 18 blocks. The Markov chain Monte Carlo method was applied to a hierarchical Bayesian model to estimate the subjective value. Chicks undervalued the variable feeder in group 1 and were indifferent in group 2 but overvalued the variable feeder in group 3 at a population level. Re-examination without the titration procedure (experiment 3) suggested that the subjective value was not absolute for each option. When the delay was varied, the variable option was often given a paradoxically high value depending on fixed alternative. Therefore, the basic assumption of the uniquely determined value function might be questioned.     

孤独症儿童共同注意的神经基础及早期干预

共同注意是指两个人共同对某一事物加以注意, 分享对该事物的兴趣, 它是儿童社会认知发展的奠基性能力。首先, 孤独症儿童共同注意发展主要体现在注视转换、主动展示、分享等能力发展滞后及缺陷; 孤独症儿童共同注意的神经基础：应答性共同注意主要涉及后部皮层注意网络(如颞上沟后部、顶内沟等), 自发性共同注意涉及前部皮层注意网络(如前扣带皮层、背内侧额叶等); 最后, 以回合式教法和关键反应训练为基本方法, 论述了共同注意干预的新近模式和效果评估。未来研究应在孤独症儿童的共同注意发展的年龄特征及机制、共同注意的脑区可塑性及脑网络的发展以及开发更有效的干预方法等方面展开大量研究。     

无边界职业生涯下职业成功的诱因与机制

职业成功(career success)作为职业生涯研究领域的一个前沿主题, 受到了理论界和实务界的广泛关注。研究主要从职业成功的概念、测量、影响因素、实施效果与作用机制等方面, 对国内外相关研究进行了系统梳理与探讨。未来研究应关注无边界职业生涯时代职业成功、开发中国组织情境下职业成功的概念和测量、基于特质激发理论视角分析职业成功的诱因、基于职业成功观分析职业成功的实施效果、探讨中国本土文化的权变作用。     

双价效应及其认知机制

任务转换时, 如果一个刺激不仅包含当前任务的特征还包含另一任务的关联特征, 这样的刺激被称为双价刺激。双价刺激能影响个体对单价刺激的加工, 使个体对后续所有单价刺激的反应减慢, 这种现象被称为双价效应(bivalency effect)。研究者发现双价效应具有一定的普遍性和稳定性。对双价效应的理论解释主要有情境捆绑说和基于经验的预测模型。双价效应的产生与额外视觉特征的提取及自上而下的认知控制调整有关, 前者主要与颞-顶联合区的激活有关, 后者主要与背侧前扣带回以及前辅助运动区的激活相关。