Medication-assisted treatment research with criminal justice populations: challenges of implementation

Creating, implementing and evaluating substance abuse interventions, especially medication-assisted treatments, for prisoners, parolees, and probationers with histories of heroin addiction is an especially challenging endeavor because of the difficulty in coordinating and achieving cooperation among diverse criminal justice, substance abuse treatment, research, and social service agencies, each with its own priorities and agenda. In addition, there are special rules that must be followed when conducting research with criminal justice-involved populations, particularly prisoners. The following case studies will explore the authors' experience of over 10 years conducting pharmacotherapy research using methadone, buprenorphine, and naltrexone with criminal justice populations. The major obstacles and how they were overcome are presented. Finally, recommendations are provided with regard to implementing and conducting research with criminal justice populations. Copyright © 2011 John Wiley & Sons, Ltd.     

Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin

Memory for delay fear conditioning requires the synthesis of new mRNA and protein in the basolateral amygdala. It is currently unknown whether similar molecular processes in the amygdala are required for the formation of trace fear memory, in which a stimulus-free interval is inserted between the conditional stimulus (CS) and unconditional stimulus (UCS). Here, we show that infusion of the protein synthesis inhibitor anisomycin into the basolateral amygdala disrupts consolidation of both trace and delay fear conditioning. This is the first evidence that protein synthesis in the amygdala is necessary for the formation of both trace and delay fear memory.     

The NEO Five-Factor Inventory: latent structure and relationships with dimensions of anxiety and depressive disorders in a large clinical sample

The present study evaluated the latent structure of the NEO Five-Factor Inventory (NEO FFI) and relations between the five-factor model (FFM) of personality and dimensions of DSM-IV anxiety and depressive disorders (panic disorder, generalized anxiety disorder [GAD], obsessive-compulsive disorder, social phobia [SOC], major depressive disorder [MDD]) in a large sample of outpatients (N = 1,980). Exploratory structural equation modeling (ESEM) was used to show that a five-factor solution provided acceptable model fit, albeit with some poorly functioning items. Neuroticism demonstrated significant positive associations with all but one of the disorder constructs whereas Extraversion was inversely related to SOC and MDD. Conscientiousness was inversely related to MDD but demonstrated a positive relationship with GAD. Results are discussed in regard to potential revisions to the NEO FFI, the evaluation of other NEO instruments using ESEM, and clinical implications of structural paths between FFM domains and specific emotional disorders.     

"Doctor, would you prescribe a pill to help me … ?" a national survey of physicians on using medicine for human enhancement

Using medical advances to enhance human athletic, aesthetic, and cognitive performance, rather than to treat disease, has been controversial. Little is known about physicians' experiences, views, and attitudes in this regard. We surveyed a national sample of physicians to determine how often they prescribe enhancements, their views on using medicine for enhancement, and whether they would be willing to prescribe a series of potential interventions that might be considered enhancements. We find that many physicians occasionally prescribe enhancements, but doctors hold nuanced and ambiguous views of these issues. Most express concerns about the potential effects of enhancements on social equity, yet many also believe specific enhancements that are safe and effective should be available but not covered by insurance. These apparently contradictory views might reflect inherent tensions between the values of equity and liberty, which could make crafting coherent social policies on medical enhancements challenging.     

The relationship between attentional capture and deviations in movement trajectories in a selective reaching task

According to action-centered models of attention, attention and action systems are tightly linked such that the capture of attention by an object automatically initiates response-producing processes. In support of this link, studies have shown that movements deviate towards or away from non-target stimuli. These deviations are thought to emerge because attentional capture by non-target stimuli generates responses that summate with target responses to develop a combined movement vector. The present study tested attention–action coupling by examining movement trajectories in the presence of non-target stimuli that do or do not capture attention. Previous research has revealed that non-target cue stimuli only capture attention when they share critical features with the target. Cues that do not share this feature do not capture attention. Following these studies and their findings, participants in the present study aimed to the location of a single white square (onset singleton target) or a single red square presented with two white squares (color singleton target). In separate blocks, targets were preceded by non-predictive cues that did or did not share the target feature (color or onset singleton cues). The critical finding of the present study was that trajectory effects mirrored the temporal interference effects in that deviations were only observed when cue and target properties matched. Deviations were not observed when the cue and target properties did not match. These data provide clear support for the link between attentional capture and the activation of response-producing processes.     

When half a face is as good as a whole: Effects of simple substantial occlusion on visual and audiovisual speech perception

The visible movement of a talker's face is an influential component of speech perception. However, the ability of this influence to function when large areas of the face (~50%) are covered by simple substantial occlusions, and so are not visible to the observer, has yet to be fully determined. In Experiment 1, both visual speech identification and the influence of visual speech on identifying congruent and incongruent auditory speech were investigated using displays of a whole (unoccluded) talking face and of the same face occluded vertically so that the entire left or right hemiface was covered. Both the identification of visual speech and its influence on auditory speech perception were identical across all three face displays. Experiment 2 replicated and extended these results, showing that visual and audiovisual speech perception also functioned well with other simple substantial occlusions (horizontal and diagonal). Indeed, displays in which entire upper facial areas were occluded produced performance levels equal to those obtained with unoccluded displays. Occluding entire lower facial areas elicited some impairments in performance, but visual speech perception and visual speech influences on auditory speech perception were still apparent. Finally, implications of these findings for understanding the processes supporting visual and audiovisual speech perception are discussed.     

Distinguishing general and specific personality disorder features and implications for substance dependence comorbidity

Clinical and population-based samples show high comorbidity between Substance Use Disorders (SUDs) and Axis II Personality Disorders (PDs). However, Axis II disorders are frequently comorbid with each other, and existing research has generally failed to distinguish the extent to which SUD/PD comorbidity is general or specific with respect to both specific types of PDs and specific types of SUDs. We sought to determine whether ostensibly specific comorbid substance dependence-Axis II diagnoses (e.g., alcohol use dependence and borderline personality disorder) are reflective of more pervasive or general personality pathology or whether the comorbidity is specific to individual PDs. Face-to-face interview data from Wave 1 and Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions were analyzed. Participants included 34,653 adults living in households in the United States. We used hierarchical factor models to statistically partition general and specific personality disorder dimensions while simultaneously testing for specific PD-substance dependence relations. Results indicated that substance dependence-Axis II comorbidity is characterized by general (pervasive) pathology and by Cluster B PD pathology over and above the relationship to the general PD factor. Further, these relations between PD factors and substance dependence diagnoses appeared to largely account for the comorbidity among substance dependence diagnoses in the younger but not older participants. Our findings suggest that a failure to consider the general PD factor, which we interpret as reflecting interpersonal dysfunction, can lead to potential mischaracterizations of the nature of certain PD and SUD comorbidities.     

Conserving Energy by Inducing People to Drive Less

We attempted to reduce college students' use of their cars with an online intervention. Every other day for 2 weeks, students reported the number of miles they had avoided driving. In a 2 × 2 design, participants received feedback about pollution avoided (e.g., CO₂ saved), financial feedback (e.g., gas money saved), or no feedback. A control group did not monitor their driving. Participants in all Web conditions reported driving less than the no‐Web control group. In addition, Web participants who received both kinds of feedback reported driving less than did those who received one kind or none. We discuss implications for research on energy conservation and offer an online feedback form to help readers reduce their own driving.     

Effects of study list composition on the word frequency effect and metacognitive attributions in recognition memory

In two experiments, study-list composition was manipulated and its impact was observed on metacognitive judgements associated with recognition hits (Hs) and false alarms (FAs). Both studies involved recognition of high-frequency (HF) and low-frequency (LF) words, and focused on the FA portion of the word frequency effect. Our hypothesis was that participants can actively reject items that are distinctive from the study list, and that this effect may be strong enough to overcome the FA word frequency effect. Experiment 1 manipulated list composition with a conjunctive rule and Experiment 2 varied it by having participants study either HF or LF items prior to a test consisting of words of both frequencies. In each study H rate, FA rate, and metacognitive attributions underlying recognition decisions were investigated. In both studies, participants reported rejecting test items predominantly through a process of active rejection, which was more often reported for LF items. This effect was strong enough to reverse the FA portion of the word frequency effect in Experiment 2, but not Experiment 1. The results are discussed in terms of metacognitive rejection mechanisms in recognition memory.     

The Impact of Passing the Professional in Human Resources Exam on Early Career Success for Undergraduates Entering the Human Resource Field

This study investigates the impact of passing the Professional in Human Resources (PHR) certification exam on the early career success of recent college graduates. Data were gathered from alumni of three Midwestern universities who earned an undergraduate degree in business administration (i.e., BBA) with a major in human resources. The survey was designed to measure early career success indicators including finding a job in the HR field, starting salary, and number of promotions. Results reveal that the probability of one's first job after graduation being in human resources was significantly greater for those who had passed the PHR exam compared with those who did not pass or did not take the exam. Passing the PHR exam was not associated with significant differences in starting salary or early career promotions. Implications, study strengths and limitations, and suggestions for future research are discussed.