Deterministic and Stochastic Postural Processes: Effects of Task,Environment, and Age

Upright standing is always environmentally embedded and typically co-occurs with another (suprapostural) activity. In the present study, the authors investigate how these facts affect postural dynamics in an experiment in which younger (M age = 20.23 years, SD = 2.02 years) and older (M age = 75.26 years, SD = 4.87 years) participants performed a task of detecting letters in text or maintaining gaze within a target while standing upright in a structured or nonstructured stationary environment. They extracted the coefficients of drift (indexing attractor strength) and diffusion (indexing noise strength) from the center of pressure (COP) time series in anteroposterior (AP) and mediolateral (ML) axes. COP standard deviation decreased with drift and increased with diffusion. The authors found that structure reduced AP diffusion for both groups and that letter detection reduced younger SD _AP (primarily by diffusion decrease) and increased older SD _ML (primarily by drift decrease). For older and younger participants, ML drift was lower during letter detection. Further, in older letter detection, larger visual contrast sensitivity was associated with larger ML drift and smaller SD _ML, raising the hypotheses that ML sway helps information detection and reflects neurophysiological age.     

Development and Psychometric Characteristics of the Dissociation Tension Scale

The newly developed Dissoziations-Spannungs-Skala (Dissociation Tension Scale; DSS) is a self-rating instrument for the assessment of psychological and somatoform dissociative features (ranging from normal up to pathological) as well as aversive inner tension occurring within the past 7 days. The DSS contains 21 items assessing dissociative symptoms and 1 additional item assessing aversive inner tension. Ratings are made on a time-oriented scale ranging from 0% (never) to 100% (constantly). We measured the psychometric qualities of the DSS in a total of 294 patients and healthy controls. Internal consistency of the DSS was high (Cronbach's α = .92; Gutmann's split-half r = .92). We found good support for convergent, discriminant, and differential validity. There was clear evidence for the DSS being a sensitive instrument for the assessment of changing symptomatology. Assessment of dissociation and other psychopathological features over the same period of time are now possible.     

Multisensory identification of natural objects in a two-way crossmodal priming paradigm

The question of how vision and audition interact in natural object identification is currently a matter of debate. We developed a large set of auditory and visual stimuli representing natural objects in order to facilitate research in the field of multisensory processing. Normative data was obtained for 270 brief environmental sounds and 320 visual object stimuli. Each stimulus was named, categorized, and rated with regard to familiarity and emotional valence by N=56 participants (Study 1). This multimodal stimulus set was employed in two subsequent crossmodal priming experiments that used semantically congruent and incongruent stimulus pairs in a S1-S2 paradigm. Task-relevant targets were either auditory (Study 2) or visual stimuli (Study 3). The behavioral data of both experiments expressed a crossmodal priming effect with shorter reaction times for congruent as compared to incongruent stimulus pairs. The observed facilitation effect suggests that object identification in one modality is influenced by input from another modality. This result implicates that congruent visual and auditory stimulus pairs were perceived as the same object and demonstrates a first validation of the multimodal stimulus set.     

A presynaptic role for FMRP during protein synthesis-dependent long-term plasticity in Aplysia

Loss of the Fragile X mental retardation protein (FMRP) is associated with presumed postsynaptic deficits in mouse models of Fragile X syndrome. However, the possible presynaptic roles of FMRP in learning-related plasticity have received little attention. As a result, the mechanisms whereby FMRP influences synaptic function remain poorly understood. To investigate the cellular locus of the effects of FMRP on synaptic plasticity, we cloned the Aplysia homolog of FMRP and find it to be highly expressed in neurons. By selectively down-regulating FMRP in individual Aplysia neurons at the sensory-to-motor neuron synapse reconstituted in co-cultures, we demonstrate that FMRP functions both pre- and postsynaptically to constrain the expression of long-term synaptic depression induced by repeated pulses of FMRF-amide. In contrast, FMRP has little to no effect on long-term synaptic facilitation induced by repeated pulses of serotonin. Since other components of signaling pathways involved in plasticity appear to be conserved between Aplysia and mammalian neurons, our findings suggest that FMRP can participate in both pre- and postsynaptic regulation of enduring synaptic plasticity that underlies the storage of certain types of long-term memory.     

Human odometry verifies the symmetry perspective on bipedal gaits

Bipedal gaits have been classified on the basis of the group symmetry of the minimal network of identical differential equations (alias cells) required to model them. Primary gaits are characterized by dihedral symmetry, whereas secondary gaits are characterized by a lower, cyclic symmetry. This fact was used in a test of human odometry. Results suggest that when distance is measured and reported by gaits from the same symmetry class, primary and secondary gaits are comparable. Switching symmetry classes at report compresses (primary to secondary) or inflates (secondary to primary) measured distance, with the compression and inflation equal in magnitude. Lessons are drawn from modeling the dynamics of behaviors executed in parallel (e.g., interlimb coordination) to model the dynamics of human odometry, in which the behaviors are executed sequentially. The major observations are characterized in terms of a dynamics of sequentially coupled measure and report phases, with relative velocity as an order parameter, or equilibrium state, and difference in symmetry class as an imperfection parameter, or detuning, of that dynamic.     

Problem solving with a simple transformation problem with and without continuous external memory support

Problem solvers can use external memory aids to represent problem information. In this study, an external problem representation was either continuously available or available on demand of the participants. Two experiments explore the hypothesis that despite the higher working memory load without a continuous external memory support, problem solvers try to reduce the cognitive costs by implementing deliberate problem solving strategies. Problem solving with and without continuous external memory support was found to be largely equivalent with high and low operator implementation costs and in problem spaces of different sizes.     

Intact emotion-induced recognition bias in neuropsychological patients with executive control deficits

In recognition memory tasks, emotionally negative words are judged more often as "old" relative to emotionally neutral words, suggesting a shift in response bias. We wondered whether this bias shift was due to the flexible regulation of executive control during memory retrieval. To address this question, we investigated individuals with high variability in executive control functions. As expected, we observed that emotional word meaning did indeed have a strong influence on the bias toward responding "old," independent of recognition accuracy and overall response bias. However, these effects were uncorrelated with executive control, as measured by the Trail Making Test, and were fully intact, even in a sample of hospitalized neurological patients with severe executive dysfunctions, some of whom had marked damage in fronto-thalamo-striatal networks. Having concluded that the emotion-induced bias must develop on different grounds, we went on to discuss alternative explanations.     

Using saccade tasks as a tool to analyze executive dysfunctions in schizophrenia

Executive dysfunctions can be frequently observed in schizophrenia. They are more persistent than psychotic symptoms and are assumed to contribute to a variety of clinical signs of the disease. However, the cognitive mechanisms underlying dysexecutive behaviors are not yet understood. The aim of this article is to demonstrate how saccade tasks can be used to analyze the mechanisms involved in the dysexecutive syndrome of schizophrenic patients. There are numerous reports showing that schizophrenic patients make many unwanted reflexive saccades in the antisaccade task. These errors are usually explained by an impairment of a distinct inhibitory mechanism. However, unwanted reflexive saccades may also be secondary to a more fundamental deficit in activating goal-directed behavior. Recent theoretical and empirical approaches to this issue are reviewed and discussed. An integrative view of deficits in inhibition, goal-directed behavior, and working memory in schizophrenic patients is proposed.     

Effects of cuing on short-term retention of order information

In two experiments, subjects recalled one of two letter sequences following a digit-filled retention interval. Recall performance was increased by precues informing subjects which letter sequence would be tested, and the cuing advantage remained throughout 60-digit retention intervals. No improvement was found, however, for cues occurring after the letters but before the digits. The cuing effects were attributed to encoding, not rehearsal, processes and were explained by a version of the Estes perturbation model, which included a long-term storage component and a fixed perturbation probability.