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71.
Fei Geng Jia Tian Jian-Lin Wu Yun Luo Wen-Jun Zou Chao Peng Gui-Feng Lu 《Cognitive, affective & behavioral neuroscience》2018,18(1):58-67
The dorsomedial prefrontal cortex (dmPFC) plays a very important role in decision-related and anxiety-related information processing. It has enriched 5-HT6 receptors; however, the precise role of dmPFC 5-HT6 receptors in anxiety remains to be fully investigated. In this study, we injected dmPFC with the 5-HT6 receptor agonist EMD 386088 and antagonist SB 271046 using stereotactic technology. 5-HT6 receptor activation in mice increased time spent in the center area on the open-field test, increased exploration of the open arms on the elevated plus maze test, and increased ratio on the social interaction test. 5-HT6 receptor inactivation induced the opposite effects. In brain slices, EMD 386088 decreased both spontaneous inhibitory postsynaptic currents (sIPSC) and spontaneous excitatory postsynaptic currents (sEPSC), while SB 271046 only increased sEPSC. These effects of EMD 386088 and SB 271046 could be reversed by the GABAA receptor antagonist bicuculline (BMI) and positive allosteric modulator clonazepam (CLZ), respectively. Our results suggest that neurotransmission in the dmPFC by 5-HT6 receptor activation and inhibition may play an important role in anxiety-like behavior, and may provide new insight into the pathological mechanism and potential target of anxiety disorders. 相似文献
72.
The purpose of this study was to clarify the impact of different self-centered moods on music preference without listening to music. Participants’ affective state (sad vs. happy vs. neutral) were experimentally manipulated through the mood induction procedure, and then their preferences for music were ascertained through self-reports. To understand participants’ internal motivations for their choices, we also asked them to indicate how appropriate he/she felt it would be to select the different music types as well as why they made such choices. Results suggested that participants in a sad mood were inclined to listen to sad (and slow) music, those in a happy mood preferred to listen to happy (and fast) music, and those in a neutral mood did not consistently prefer to listen to neutral music. In addition, participants were averse to sad music when they were in a happy or neutral mood; while they showed no aversion to happy music when they were in a sad mood. In conclusion, individuals select valence-consistent music when they are in an autobiographical memory-induced mood state. 相似文献
73.
在"生命"反抗"形式"的现代性文化境遇下,传统宗教也发生了现代转化,即宗教信仰成为宗教生命冲动的表达,这既使"宗教"由外在建构走向活生生的内在的"宗教性"生存,也面临着失去确定的形而上学目标的现代性困境。走出这一困境只能通过一条内在的精神的途径,就是将"灵魂的宗教性存在本身"视为"形而上学的价值",由此跳出主体需要和客体对象之间的二元对立,故而,确立起灵魂存在的形而上学宗教性的自觉意识和内在信仰是宗教现代性重建的关键。 相似文献
74.
该研究以城市移民子女作为研究对象,主要探讨社会支持对城市移民子女生活满意度的影响及预测作用,以及学校适应在社会支持与生活满意度之间的作用机制。研究结果表明:1)社会支持、学校适应与城市移民子女的生活满意度均呈显著相关,社会支持对城市移民子女生活满意度具有显著的正向预测作用。2)学校适应在社会支持影响城市移民子女生活满意度中起部分中介作用,即社会支持可以直接影响生活满意度,也可以通过学校适应间接影响生活满意度。但社会支持对生活满意度的直接影响是最主要的影响路径。. 相似文献
75.
Papaleo F Silverman JL Aney J Tian Q Barkan CL Chadman KK Crawley JN 《Learning & memory (Cold Spring Harbor, N.Y.)》2011,18(8):534-544
BDNF regulates components of cognitive processes and has been implicated in psychiatric disorders. Here we report that genetic overexpression of the BDNF mature isoform (BDNF-tg) in female mice impaired working memory functions while sparing components of fear conditioning. BDNF-tg mice also displayed reduced breeding efficiency, higher anxiety-like scores, high self-grooming, impaired prepulse inhibition, and higher susceptibility to seizures when placed in a new empty cage, as compared with wild-type (WT) littermate controls. Control measures of general health, locomotor activity, motor coordination, depression-related behaviors, and sociability did not differ between genotypes. The present findings, indicating detrimental effects of life-long increased BDNF in mice, may inform human studies evaluating the role of BDNF functional genetic variations on cognitive abilities and vulnerability to psychiatric disorders. 相似文献
76.
Little is known regarding how attention to emotional stimuli is affected during simultaneously performed exercise. Attentional biases to emotional face stimuli were assessed in 34 college students (17 women) using the dot-probe task during counterbalanced conditions of moderate- (heart rate at 45% peak oxygen consumption) and high-intensity exercise (heart rate at 80% peak oxygen consumption) compared with seated rest. The dot-probe task consisted of 1 emotional face (pleasant or unpleasant) paired with a neutral face for 1,000 ms; 256 trials (128 trials for each valence) were presented during each condition. Each condition lasted approximately 10 min. Participants were instructed to perform each trial of the dot-probe task as quickly and accurately as possible during the exercise and rest conditions. During moderate-intensity exercise, participants exhibited significantly greater attentional bias scores to pleasant compared with unpleasant faces (p < .01), whereas attentional bias scores to emotional faces did not differ at rest or during high-intensity exercise (p > .05). In addition, the attentional bias to unpleasant faces was significantly reduced during moderate-intensity exercise compared with that during rest (p < .05). These results provide behavioral evidence that during exercise at a moderate intensity, there is a shift in attention allocation toward pleasant emotional stimuli and away from unpleasant emotional stimuli. Future work is needed to determine whether acute exercise may be an effective treatment approach to reduce negative bias or enhance positive bias in individuals diagnosed with mood or anxiety disorders, or whether attentional bias during exercise predicts adherence to exercise. 相似文献
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79.
本文以明清之际儒生天主教徒论及"十诫"的著述为基础,探讨他们对"十诫"不同于耶稣会士的的诠释.文本诠释活动是建构身份的重要手段之一,本文关注儒生天主教徒如何通过对"十诫"的诠释而建构他们的身份,从而呈现本土文化对基督教在中国的文化植根所作的回应与贡献. 相似文献
80.
本文简要介绍了基于示例学习的认知技能获得的研究,涉及的问题包括示例学习的过程、影响认知技能获得的因素、认知技能获得中的练习和迁移等、在文章的最后,对这一领域的研究趋势进行了展望。 相似文献