微流控分析芯片在循环肿瘤细胞检测中的运用

随着人们对于肿瘤性疾病的发生、发展、转移机制的进一步探索,循环肿瘤细胞（CTCs）逐渐进入人们视野,其应用价值日益体现,可用于肿瘤性疾病的早期诊断及治疗效果的监测,尤其是对于早期肿瘤的诊断具有独特优势。其富集技术及检测方法也在发生着日新月异的变化。近年来,微流控分析芯片技术运用于 CTCs 的富集及检测,具有高丰度、高富集度、高活性及不需要对样本进行预处理等优点使得人们聚焦于此技术,本文对微流控分析芯片在 CTCs 检测中的运用做简要综述。     

中文版一般自我效能量表的信度和效度检验

该研究以山东省610名高中生为被试,检验了中文版一般自我效能量表（GSES）的信度和效度.结果表明：（1）中文版GSES的有些项目,区分度不高;（2）中文版GSES具有较高的内部一致性信度与分半信度,但重测信度不高;（3）中文版GSES的单维度性没有得到证实;（4）中文版GSES不具有很好的预测效度.     

Relationships Between Social Support,Internal Assets,and Life Satisfaction in Korean Adolescents

In previous literature, social support has been reported to have a significant, positive relationship with life satisfaction. However, few studies have examined this relationship among Korean youths and how their psychological functioning is associated with both social support and life satisfaction. This study investigated the associations between different sources of social support (i.e., family, peer, and teacher), psychological factors (i.e., self-efficacy and emotional regulation), and life satisfaction, in a sample of 1133 Korean adolescents. The possibility of sex differences in these relationships was also investigated. Results indicated that only family support had a direct relationship with life satisfaction for male adolescents; however, all three types of social support were found to have a significant, indirect relationship with life satisfaction for male adolescents through both psychological factors. In contrast, all three types of social support had a direct relationship with life satisfaction of female adolescents. Additionally, self-efficacy had a mediating effect on the relationship between the social support from family and teachers and life satisfaction of female adolescents. The results and implications of the study are discussed.     

内隐多效性选择的ERP证据

采用事件相关电位技术,考察内隐多效性选择及其神经机制。被试的任务是认真观看配对的纯色图片刺激,并进行分类按键反应。实验结果发现,在P2上,积极启动刺激比对照刺激激发了更大的P2波幅; 对比对照刺激,积极启动刺激在左脑、大脑中部和后脑诱发了更大的P2波幅,其中右脑的效应最大。在N2上,积极启动刺激比对照刺激激发了更小的N2波幅; 对比对照刺激,积极启动刺激在左脑、大脑中部和后脑诱发了更小的N2波幅,其中右脑的效应最大。在P3上,积极启动刺激比对照刺激激发了更大的P3波幅; 对比对照刺激,积极启动刺激在左脑、大脑中部和后脑诱发了更大的P3波幅,其中右脑的效应最大。研究结果表明当外显目标与内隐目标同时被呈现时,被试趋向于做多效性选择,这可能表明无意识信息加工具有相当大的权重。且右后部脑区可能是加工多效性刺激的核心和关键区域,P3成分可能反应了内隐多效性选择的精细加工过程,能够作为内隐多效性选择的有效的ERPs指标。     

自我损耗、情绪动机对冲动决策的影响

以大学生为被试,探讨自我损耗、情绪动机对冲动决策的影响。采用2×2×2的混合实验设计,组内变量为自我损耗,组间变量为情绪动机方向和强度,使用双任务范式操作自我损耗,使用情绪动机图片启动被试的情绪动机,使用延迟折扣任务的指标k值测量冲动决策。结果发现,高趋近动机的k值大于低趋近动机,高回避动机的k值大于低回避动机。结果表明,自我损耗、情绪动机对冲动决策有明显影响。     

青少年大五人格对网络成瘾的影响:家庭功能的中介作用

目的:探究家庭功能在人格特征与网络成瘾之间的中介作用。方法:973名中学生被试完成基本人口学问卷、网络成瘾量表、人格五因素问卷、家庭功能评定量表。结果:(1)人格特征可以显著预测网络成瘾。其中,情绪性人格可以显著正向预测网络成瘾,责任心、宜人性显著负向预测网络成瘾。(2)家庭功能在情绪性、责任心对网络成瘾的影响具有部分中介作用、在宜人性对网络成瘾的影响具有完全中介作用。结论:在治疗中,可针对网络成瘾者的家庭功能进行积极干预,从而减轻其成瘾症状。     

Impact of a Patient-Facing Enhanced Genomic Results Report to Improve Understanding,Engagement, and Communication

“The objective of this study was to” test the effectiveness of an enhanced genomic report on patient-centered outcome domains including communication, engagement and satisfaction. “Study design utilized” a prospective, randomized, mixed-methods desctiptive study of a whole genome sequencing results report, GenomeCOMPASS?, that was accessed by providers through the electronic health record and by patients through the associated patient portal. “The study was set in” an integrated healthcare delivery system in central Pennsylvania. “Eighty-four” parents of 46 children with undiagnosed Intellectual Disability, Autism Spectrum Disorder and/or multiple congenital anomalies who had participated in a previous study offering whole genome sequencing for their affected child were invited to enroll. Fifty-two parents enrolled. Following a traditional genetics results informing visit, the study coordinator stratified families by diagnostic result and uninformative result and then randomized families within each group to an intervention arm to receive the GenomeCOMPASS? report or to the usual care arm to receive a summary letter from the medical geneticist. A letter inviting enrollment included a baseline survey, which once returned, constituted enrollment. Surveys were administered at 3 months post-genetics visit. At 6 months, the usual care arm crossed over to receive the intervention and were administered an additional survey at 3 months. Qualitative interviews were conducted following survey completion to augment the survey data regarding the patient centered outcomes of interest. Patient reported outcomes including communication, engagement, empowerment and satisfaction. In the intervention arm, GenomeCOMPASS? reports were released to 14 families (N?=?28 parents) and of those 21 (75%) returned 3 month surveys. In the usual care arm, 12 families (N?=?24 parents) received usual care summary letters and of those 20 (83%) returned 3 month surveys. At crossover, GenomeCOMPASS? reports were released to 20 individuals and 15 (75%) returned 3 month surveys. Qualitative interviews were conducted with 5 individuals. Use of the GenomeCOMPASS? report was reported by this small group of parents to improve communication with providers and non-health professionals such as educators and therapists and led to increased engagement and high satisfaction. Providers and others involved in the children’s care also endorsed the report’s effectiveness. Reports that addressed negative findings, i.e. uninformative results, were not found to be useful. Although the number of users was small, this study supports that customizable template reports may provide a useful and durable source of information that can support and enhance the information provided by genetics professionals in traditional face-to-face encounters. Trial registration: Clinicaltrials.gov (Record 2013–0594).     

前瞻记忆的情绪一致性反转效应

采用经典双任务实验范式,探讨前瞻记忆的情绪一致性效应及其理论模型。情绪电影片段诱发被试高兴或悲伤情绪后,观察被试在高兴、悲伤和自然情绪状态下的前瞻记忆任务和当前任务的成绩。结果发现,情绪一致性前瞻记忆出现反转效应,即在高兴背景下前瞻记忆负性词比正性词成绩好,在悲伤背景下前瞻记忆正性词比负性词成绩好。实验结果支持前瞻记忆的注意—搜索模型,不支持自动激活模型。     

大学生学习动机问卷的初步编制

本研究结合开放式问卷所获资料,在文献研究的基础上建构了大学生学习动机的维度,编制了大学生学习动机问卷,并将之施测于427名大学生。问卷的因素分析结果表明：（1）大学生学习动机归并为求知兴趣、能力追求、声誉获取和利他取向四个维度;（2）自编大学生学习动机问卷的信度和效度指标均达到了心理测量学要求。