Failures to retrieve specific memories in previously depressed individuals: random errors or content-related?

Failures to retrieve specific memories have been related to general tendencies to commit errors in executive functioning tasks, raising the question of whether they are simply a reflection of randomly occurring lapses in cognitive control or whether their occurrence is in any way related to memory content. This study investigated the relation between failures to retrieve specific autobiographical memories and dysfunctional attitudes in individuals at risk for depression and controls. Sixteen previously depressed and 19 never-depressed participants were assessed for dysfunctional attitudes regarding "need for approval" and "performance evaluation". One week later, they were asked to generate specific memories following dependency- and achievement-related cue words, both under single and dual task conditions. In previously depressed participants, dysfunctional attitudes regarding "need for approval" significantly predicted specificity for dependency-related events under dual task conditions. The findings provide qualified support for a role of content and demonstrate how, in previously depressed individuals, content effects can surface when cognitive control is undermined.     

Reduced K+ Channel Inactivation, Spike Broadening, and After-Hyperpolarization in Kvβ1.1-Deficient Mice with Impaired Learning

A-type K⁺ channels are known to regulate neuronal firing, but their role in repetitive firing and learning in mammals is not well characterized. To determine the contribution of the auxiliary K⁺ channel subunit Kvβ1.1 to A-type K⁺ currents and to study the physiological role of A-type K⁺ channels in repetitive firing and learning, we deleted the Kvβ1.1 gene in mice. The loss of Kvβ1.1 resulted in a reduced K⁺ current inactivation in hippocampal CA1 pyramidal neurons. Furthermore, in the mutant neurons, frequency-dependent spike broadening and the slow afterhyperpolarization (sAHP) were reduced. This suggests that Kvβ1.1-dependent A-type K⁺ channels contribute to frequency-dependent spike broadening and may regulate the sAHP by controlling Ca²⁺ influx during action potentials. The Kvβ1.1-deficient mice showed normal synaptic plasticity but were impaired in the learning of a water maze test and in the social transmission of food preference task, indicating that the Kvβ1.1 subunit contributes to certain types of learning and memory.     

Psychosocial Impact of Familial Adenomatous Polyposis on Young Adults: A Qualitative Study

The aim of this study was to explore in detail the psychosocial impact of either having familial adenomatous polyposis (FAP) or being at risk for FAP amongst young adults. In-depth interviews were conducted with eleven individuals aged 18–35 with a clinical or genetic diagnosis of, or at risk of developing FAP. While being at risk did not seem to have a major psychosocial impact upon clinically unaffected participants, clinically affected individuals discussed a number of major stressors including issues in relation to changes in body image and physical functioning as a result of surgery, concerns about discussing FAP with new partners, difficulties in relation to childbearing decision-making, and impact on employment. Genetic counseling was described as being highly effective in providing support, but most participants were not aware of any other support services. Providing longer-term support through ongoing genetic counseling appears necessary to adequately address the ongoing challenges faced by young adults who are dealing with FAP.     

Boundaries of the relation between conscious recollection and source memory for perceptual details

The relation between conscious recollection and source memory for perceptual details was investigated in three experiments that combined the remember-know paradigm with a multidimensional source monitoring test. Experiment 1 replicated that source memory for perceptual details is better in the case of "remember" than "know" judgments. Experiment 2 showed that the relation between "remember" judgments and source memory for perceptual details is diminished by a semantic orienting task during encoding. Experiment 3 demonstrated that "remember" judgments are related to enhanced source memory for specific and unique kinds of perceptual source information, whereas memory for incomplete and global perceptual source information does not differentiate between "remember" and "know" judgments. The results show that the attentional focus during encoding and the specificity of retrieved source information form boundary conditions for the use of source memory for perceptual details as a basis of "remember" judgments.     

Assessment of Psychosocial Outcomes in Genetic Counseling Research: An Overview of Available Measurement Scales

The aim of the present paper was to describe and evaluate many of the measurement scales currently used in genetic counseling outcomes research. A team of three researchers reviewed the available literature and selected a variety of validated instruments suitable for measurement of genetic counseling outcomes. There are numerous scales to assess each of the following outcomes among counselees: satisfaction with genetic counseling; knowledge; decision-making; psychological adjustment; coping; perceived personal control; perceptions of disease risk; and family communication about genetic risk. However, the strengths and limitations inherent to each instrument warrant careful consideration prior to implementation. In the genetic counseling context, scale selection should be undertaken with thought directed towards the characteristics of the research sample (e.g. levels of literacy, culture, medical condition), the practicalities of the research setting (e.g. available funding and resources, time restrictions, researcher expertise), the purpose of the research (i.e. the specific aspect of the genetic counseling experience to be studied), and the science underlying the scale (e.g. theoretical framework, psychometric properties).     

Cognitive processes in stereotype formation: the role of correct contingency learning for biased group judgments

Three studies investigated contingency learning and stereotype formation in a scenario about group membership and behavior with a confounding context factor. The studies tested predictions from theoretical accounts of biased group judgments in terms of simplistic reasoning, parallel distributed memory, and pseudocontingencies. Study 1 revealed a positive correlation between erroneous stereotype formation and learning of the true contingencies with the confounding factor. Study 2 showed that a focus manipulation during encoding moderated the correlation between stereotype formation and contingency learning but not the strength of the erroneous stereotype. Study 3 used a quasiexperimental comparison between participants with biased versus unbiased group judgments and extended the findings of a positive relation between stereotype formation and contingency learning. The results support an explanation of biased group judgments by pseudocontingencies; that is, unwarranted inferences from accurately perceived bivariate correlations in complex environments.     

Spontaneous prospective-memory processing: Unexpected fluency experiences trigger erroneous intention executions

Event-based prospective memory is the ability to remember to execute an intention when an environmental cue occurs. It has been argued that, due to their special meaning, these cues are discrepant from their environment and therefore are sometimes spontaneously noticed. In line with this assumption, the likelihood that an intention will be executed increases with increased cue-discrepancy. It is not yet clear, however, whether these improvements are due to facilitated spontaneous noticing rather than to an increase in the efficiency of controlled cue-processing. To further investigate the spontaneous nature of cue-discrepancy benefits, we presented participants with stimuli that were unrelated to the intention but discrepant from other stimuli. Therefore, we experimentally increased the processing fluency of some stimuli for participants currently holding an intention by using different priming procedures. We found that stimuli whose fluency was increased via spaced repeated stimulus presentation (Experiment 1) or via short pre-exposure (Experiment 2a to 3) elicited a tendency to fulfill the intention despite its actual inappropriateness. Findings were inconsistent as to whether cue-memory uncertainty fosters the reliance on cue discrepancy for intention retrieval (Experiments 2a and 3). Taken together, the present findings provide converging evidence for a spontaneous discrepancy-based prospective-memory process which works independent of controlled processes.