Effects of uncertainty on melodic information processing

In three experiments, musically trained and untrained adults listened to three repetitions of a 5-note melodic sequence followed by a final melody with either the same tune as those preceding it or differing in one position by one semitone. In Experiment 1, ability to recognize the final sequence was examined as a function of redundancy at the levels of musical structure in a sequence, contour complexity of transpositions in a trial, and trial context in a session. Within a sequence, tones were related as the major or augmented triad; within a trial, the four sequences began on successively higher notes (simple macrocontour) or on randomly selected notes (complex macrocontour); and within a session, trials were either blocked (all major or all augmented) or mixed (major and augmented randomly selected). Performance was superior for major melodies, for systematic transpositions within a trial (simple macrocontours), for blocked trials, and for musically trained listeners. In Experiment 2, we examined further the effect of macrocontour. Performance on simple macrocontours exceeded that on complex, and excluded the possibility that repetition of the 20-note sequences provided the entire benefit of systematic transposition in Experiment 1. The effect of musical structure (major/augmented) was also replicated. In Experiment 3, listeners provided structure ratings of ascending 20-note sequences from Experiment 2. Ratings on same trials were higher than those on corresponding different trials, in contrast to performance scores for augmented same and different trials in previous experiments. The concept of functional uncertainty was proposed to account for recognition difficulties on augmented same trials. The significant effects of redundancy on all the levels examined confirm the utility of the information-processing framework for the study of melodic sequence perception.     

Intracerebroventricular Administration of Mineralocorticoid Receptor Antisense Oligonucleotides Attenuates Salt Appetite in the Rat

The anterior ventral third ventricle (AV3V) region of the brain contains high concentrations of mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) that are important in the maintenance of body fluid and electrolyte balance as well as other physiological processes. Daily intracerebroventricular pulse injections of MR antisense oligonucleotides significantly suppressed deoxycorticosterone acetate (DOCA) induced salt appetite in a dose-related manner. Similar administration of GR antisense or scrambled/sense oligonucleotide into the third ventricle failed to inhibit salt appetite. Salt appetite aroused after adrenalectomy was not suppressed by MR antisense oligonucleotide treatments but was suppressed by an antisense oligonucleotide directed against the angiotensin II AT1 receptor subtype. Receptor binding analysis demonstrated that MR and GR oligonucleotide treatments each reduced their respective receptor subtypes. Finally, although GR antisense oligonucleotide treatment was ineffective in suppressing DOCA-induced salt appetite, this treatment did increase stress induced corticosterone release as well as delayed the recovery of corticosterone to basal levels after stress.     

Effect of information on reducing inappropriate expectations and requests for antibiotics

People often expect antibiotics when they are clinically inappropriate (e.g., for viral infections). This contributes significantly to physicians’ decisions to prescribe antibiotics when they are clinically inappropriate, causing harm to the individual and to society. In two pre-registered studies employing UK general population samples (n₁ = 402; n₂ = 190), we evaluated the relationship between knowledge and beliefs with antibiotic expectations, and the effects of information provision on such expectations. We conducted a correlational study (study 1), in which we examined the role of antibiotic knowledge and beliefs and an experiment (study 2) in which we assessed the causal effect of information provision on antibiotic expectations. In study 1, we found that both knowledge and beliefs about antibiotics predicted antibiotic expectations. In study 2, a 2 (viral information: present vs. absent) × 2 (antibiotic information: present vs. absent) experimental between-subjects design, information about antibiotic efficacy significantly reduced expectations for antibiotics, but viral aetiology information did not. Providing antibiotic information substantially diminishes inappropriate expectations of antibiotics. Health campaigns might also aim to change social attitudes and normative beliefs, since more complex sociocognitive processes underpin inappropriate expectations for antibiotics.     

The Relationship Between Premenstrual Distress and Anxiety Sensitivity: The Mediating Role of Rumination

Given that premenstrual distress is reported by large numbers of women, research has focused on the identification of biological and psychological factors that influence its severity. Previous research suggests that women who are high in anxiety sensitivity also report greater levels of premenstrual distress and negative affect. According to the menstrual reactivity hypothesis, women who have a tendency to self-focus and catastrophize about physical sensations are more likely to report greater levels of premenstrual distress. Cognitive schemas surrounding the menstrual cycle develop that are influenced by gender roles, cultural stereotypes, and expectations about bodily sensations. Another cognitive process, rumination, may also be linked to increased reports of premenstrual distress. Conceptually, the constructs of anxiety sensitivity and rumination share the tendency to self-focus on internal states. The goal of this study was to investigate how these two constructs relate to the prediction of premenstrual distress in a large sample of healthy undergraduate women (N = 478). Using mediational modeling, support was found for a mediational model; women who reported high levels of rumination and anxiety sensitivity reported the greatest premenstrual distress. These results are discussed within the framework of the menstrual reactivity hypothesis, a diathesis-stress model of premenstrual distress.     

Associations between prenatal maternal mental health indices and mother–infant relationship quality 6 to 18 months’ postpartum: A systematic review

Maternal mental disorders can significantly impact on children's psychosocial and psychological development, incurring substantial ongoing economic and personal costs. A key mediating mechanism is mother–infant relationship quality (MIRQ). Research studies and perinatal mental health screening initiatives have predominantly focused on depressive symptoms and perinatal depression as predictors of MIRQ. While maternal depression is associated with suboptimal MIRQ, the findings have not been consistent. Personality characteristics are associated with parenting and proneness to depression, presenting a potential addition to prenatal mental health assessment. We conducted a systematic review of studies that have examined the link between prenatal depressive symptoms and/or personality characteristics with postnatal MIRQ. Our findings suggest that both maternal personality traits and depressive symptoms measured in early pregnancy are associated with postnatal MIRQ. A measure of personality characteristics may enhance prenatal mental health assessment, affording opportunities for targeted intervention commencing in pregnancy to improve MIRQ, parenting, maternal mental health outcomes, and infant psychosocial and psychological development, and thereby contributing to the reduction of human and economic cost burdens.     

Latent Trait Modeling with the Common beliefs Survey III: Using Item Response Theory to Evaluate an Irrational Beliefs Inventory

Assessment of irrational beliefs by such measures as the Common Beliefs Survey III (CBS) has traditionally relied upon classical test theory assumptions, in which the properties of specific test items are less important than the total test score as the aggregate of all item responses. An alternative approach using item response theory (IRT) methodology allows one to specify the parameters of difficulty and discrimination for each test item. Difficulty levels of CBS items range along a continuum of irrationality, the implied latent trait measured by responses to the questionnaire as a whole. We evaluated the CBS responses of 605 individuals from clinical and college settings, drawing from current and archival data. The original Likert scale ratings were recoded into dichotomous scores. Fourteen of the 54 items were highly or very highly discriminating in distinguishing respondents with high and low irrationality levels. However, discriminating items exhibited a very narrow range of difficulty; most functioned at a point a little above the halfway mark on the continuum of irrationality. Item characteristic curves and test information curves were very similar for female (n = 424) and male (n = 179) respondents. We derived a 4-item screening test for irrationality from our IRT analyses of the 54 CBS items. Further test development, focused on the selection and scaling of items with a much broader range of difficulty, would facilitate evaluation of the hierarchical structure of irrational beliefs. Portions of this paper were presented at the 39th Annual Convention of the Association for Behavioral and Cognitive Therapies, Washington, DC, November, 2005.     

Effects of task requirements on rapid natural scene processing: from common sensory encoding to distinct decisional mechanisms

Using manual responses, human participants are remarkably fast and accurate at deciding if a natural scene contains an animal, but recent data show that they are even faster to indicate with saccadic eye movements which of 2 scenes contains an animal. How could it be that 2 images can apparently be processed faster than a single image? To better understand the origin of this speed advantage in forced-choice categorization, the present study used a masking procedure to compare 4 tasks in which sensory, decisional, and motor aspects were systematically varied. With stimulus onset asynchronies (SOAs) above 40 ms, there were substantial differences in sensitivity between tasks, as determined by d' measurements, with an advantage for tasks using a single image. However, with SOAs below 30-40 ms, sensitivity was similar for all experiments, despite very large differences in reaction time. This suggests that the initial part of the sensory encoding relies on common and parallel processing across a large range of tasks, whether participants have to categorize the image or locate a target in 1 of 2 scenes.