A hermeneutics of the natural sciences? The debate updated

The initial obstacle to the development of a hermeneutics of the natural sciences has been the inadequate translation, and thus misunderstanding, of the basic terms of Heidegger's ontological analysis ofthe protopractical human situation and its progressive technicization. Pragmatism's parallel analyses of the problem situation of scientists has promoted a more idiomatically English vocabulary. But 1) Gadamer's exclusion of domains and disciplines working with technical methods from his universal hermeneutics continues to be influential, this in spite of the genesis of his project in Helmholtz's insights into the process of scientific discovery. 2) Markus thus depicts a distinctly different style of production, transmission, and reception of the technological texts of natural science. 3) Rouse's 1987 extension of pragmatic hermeneutics into the incipient politics of knowledge/power relations in laboratory science presents the usual frightening prospects connected with laboratory experimentation impacting on disciplinary social institutions. 4) Rouse's 1996 analysis of scientific practices in local narrative situations eschews the banner of hermeneutics and instead proposes to examine scientific-technological work by way of interdisciplinary cultural studies, once the traditional loci of hermeneutic methodology. 5) A hermeneutic phenomenology of the natural sciences thus finds itself fundamentally challenged with respect to its rightful topics and roles in the analysis of increasingly technicized disciplines and domains.     

An electromechanical analyzer using histogram techniques

In behavioral studies it is often necessary to classify events and store the number of events occurring in each classification. The classification requirements may be either functions of amplitude (i.e., intensity, force, peaks, etc.) or time (i.e., duration, interval, etc.). The following describes an analyzer capable of classifying events according to their duration, interval, or time of occurrence, and storing and displaying the number of such events in each classification.     

An analysis of some conditions for representingN state Markov processes as general all or none models

Recently Markov learning models with two unidentifiable presolution success states, an error state, and an absorbing learned state, have been suggested to handle certain aspects of data better than the three state Markov models of the General All or None model type. In attempting to interpret psychologically, and evaluate statistically the adequacy of various classes of Markov models, a knowledge of the relationship between the classes of models would be helpful. This paper considers some aspects of the relationship between the class of General All or None models and the class of Stationary Absorbing Markov models withN error states, andM presolution success states.     

Idiosyncratic exceptions to the probability-matching decision-rule in visual discrimination

Human “Yes-No” signal-detection performance was tested under a modified perceptual-defense procedure. A majority of Ss tended to match the relative frequency with which they gave affirmative responses to the relative frequency at which signals were presented. These Ss thereby replicated the “probability-matching” behavior found in previous signal-detection and discrimination studies. However, in marked contrast to those previous results, another large set of Ss showed a tendency toward preponderant use of one of the two responses (typically, of “No”) rather than toward probability-matching. The evidence failed to suggest that the latter effect was related to a lesser ability to make the requisite sensory discrimination or to response inhibition induced by taboo stimuli.     

Differential Effect of TEA on Long-Term Synaptic Modification in Hippocampal CA1 and Dentate Gyrus in vitro

The effectiveness of tetraethylammonium (TEA) and high-frequency stimulation (HFS) in inducing long-term synaptic modification is compared in CA1 and dentate gyrus (DG) in vitro. High-frequency stimulation induces long-term potentiation (LTP) at synapses of both perforant path-DG granule cell and Schaffer collateral-CA1 pyramidal cell pathways. By contrast, TEA (25 mM) induces long-term depression in DG while inducing LTP in CA1. The mechanisms underlying the differential effect of TEA in CA1 and DG were investigated. It was observed that T-type voltage-dependent calcium channel (VDCC) blocker, Ni²⁺ (50 μM), partially blocked TEA-induced LTP in CA1. A complete blockade of the TEA-induced LTP occurred when Ni²⁺ was applied together with the NMDA receptor antagonist, D-APV. The L-type VDCC blocker, nifidipine (20 μM), had no effect on CA1 TEA-induced LTP. In DG of the same slice, TEA actually induced long-term depression (LTD) instead of LTP, an effect that was blocked by D-APV. Neither T-type nor L-type VDCC blockade could prevent this LTD. When the calcium concentration in the perfusion medium was increased, TEA induced a weak LTP in DG that was blocked by Ni²⁺. During exposure to TEA, the magnitude of field EPSPs was increased in both CA1 and DG, but the increase was substantially greater in CA1. Tetraethylammonium application also was associated with a large, late EPSP component in CA1 that persisted even after severing the connections between CA3 and CA1. All of the TEA effects in CA1, however, were dramatically reduced by Ni²⁺. The results of this study indicate that TEA indirectly acts via both T-type VDCCs and NMDA receptors in CA1 and, as a consequence, induces LTP. By contrast, TEA indirectly acts via only NMDA receptors in DG and results in LTD. The results raise the possibility of a major synaptic difference in the density and/or distribution of T-type VDCCs and NMDA receptors in CA1 and DG of the rat hippocampus.     

ON MISREADING AND MISLEADING PATIENTS: SOME REFLECTIONS ON COMMUNICATIONS,MISCOMMUNICATIONS AND COUNTERTRANSFERENCE ENACTMENTS1

This author focuses on an aspect of transference countertransference interaction that enacted covertly is often overlooked. He argues that conflicts, needs and biases that may go undetected for lengthy periods of time are not infrequently contained within the analyst's accurate and technically correct interventions and that for defensive reasons, patients often suppress, deny or rationalise their accurate perceptions of these countertransference elements and fail to confront their analysts with them. The mistakes, miscommunications and misperceptions that arise as a consequence of the unconscious collusions that develop between patient and analyst can have a profound effect on the analytic work. Several clinical examples are presented to illustrate the operation of such covert communications in analysis and their impact on the treatment process.     

Utility of the Millon Behavioral Medicine Diagnostic (MBMD) to predict adherence to highly active antiretroviral therapy (HAART) medication regimens among HIV-positive men and women

Psychosocial and behavioral factors may be strong predictors of adherence to medications in a wide variety of diseases. Newly emerging antiretroviral medications for HIV have been shown to be effective but require near perfect adherence to offer clinically significant benefits. There is currently great interest in deriving patient factors that may predict optimal medication adherence in HIV-positive persons. In this study, we examined the association of psychosocial and behavioral characteristics using the Millon Behavioral Medicine Diagnostic (MBMD; Millon, Antoni, Millon, Meagher, & Grossman, 2001) and adherence to highly active antiretroviral therapy (HAART) among 117 HIV-positive individuals on HAART regimens. Specific indexes of the MBMD were associated with HAART adherence as assessed through patient interview, at baseline assessment, and at 3-month follow-up at a point after which participants had received medication adherence training. As hypothesized, the Medication Abuse scale of the MBMD was uniquely associated with overall adherence at baseline assessment and also predictive of adherence at 3-month follow-up. Additional MBMD scales were also related to overall adherence as well as specific adherence behaviors such as missed doses, following specific instructions, and overmedicating, although the Medication Abuse scale emerged as the most consistent predictor of adherence in the study. These results suggest that the MBMD can be used to predict adherence to HAART medication in a sample of HIV-positive men and women and may subsequently be used to identify those in need of adherence counseling at the point when medications are initiated.