Behavioral effects of chronic melatonin and pregnenolone injections in a myelin mutant rat (taiep)

The taiep (tremor, ataxia, immobility, epilepsy, and paralysis) myelin mutant displays a number of locomotor deficits. Taiep rat gait is characterized by shorter stride and step lengths as well as by larger stride widths. Thirty-day-old taiep mutants were placed under a regimen of daily hormone injections for 60 days. Animals in Condition 1 received melatonin, those in Condition 2 received pregnenolone sulfate, and those in a third control condition received injections of saline. Following the injections, each taiep mutant's gait was analyzed. The animals that received melatonin and pregnenolone displayed significantly larger stride and step lengths than did the controls. In addition, the animals that received hormones displayed shorter stride widths than did the controls. These experimental effects are consistent with a normalization of gait. Possible cellular mechanisms of this behavioral effect are discussed.     

Contributions of endothermy to huddling behavior in infant Norway rats (Rattus norvegicus) and Syrian golden hamsters (Mesocricetus auratus)

Infant Syrian golden hamsters (Mesocricetus auratus) do not exhibit endogenous heat production before 3 weeks of age and do not huddle effectively during cold exposure, gaining little thermoregulatory benefit from the presence of multiple littermates. In contrast, infant Norway rats (Rattus norvegicus) produce heat endogenously and are effective at maintaining elevated body temperatures by huddling. Therefore, the ineffective huddling of infant hamsters may be due to the absence of endogenous heat production. The huddling behavior of infants in mixed huddles of 8-day-old hamsters and weight-matched 4-5-day-old rats was observed to explore this possibility. The results indicate that hamsters, even when cold, effectively gain access to heat-producing rats, supporting the idea that endothermy contributes to the behavior of huddling by providing heat to each individual and thermal stimuli to other infants to support aggregation.     

Empathy and generalized reciprocity in compliance with requests for help

This study examined empathy and reciprocity as explanations for why people comply with requests for help. Participants (35 male and 62 female) imagined being asked for money by a person who had locked keys in a car and then reported how likely they would he to comply with such a request, whether they had previously locked their keys in their car (empathy), and, if so, whether they had been helped (reciprocity). In support of the explanation based on empathy, people who reported previously locking their keys in their cars indicated being more likely to comply.     

Division of the corpus callosum into subregions

Various attempts have been made to subdivide the corpus callosum (CC) into anatomically and functionally distinct subareas. A promising current approach is the use of factor analytic techniques in conjunction with traced MRI images. The traced images are divided into 99 percentile slices, where the widths of the percentile slices are used as variables that are entered into the analysis (Denenberg, Kertesz & Cowell, 1991). Studies that use this technique agree broadly between 6 and 7 factors, but available factor solutions contain inconsistencies and large gaps, which arise when many of the percentile slices do not load appreciably on any of the factors. The present study uses a larger number of brains (N = 184), all normalized, and some methodological refinements in the analysis of the traced MRI images of the CC. A stable 7 factor solution was found, and the factor structure for males and females was very similar.     

Measuring the search image: expectation,detection, and recognition in pigeon visual search

Pigeons searched computer screens for a grating target that varied in spatial frequency and orientation. In Experiment 1, a pretrial cue signaled that a particular target would appear. The cue speeded response to this primed target and to targets of the same orientation and similar spatial frequency to the primed target. However, the cue slowed search for targets differing from the primed target in orientation. In Experiment 2, pecks to a single target were reinforced. Responding generalized somewhat to targets of spatial frequency similar to the primed target and to targets of either orientation. Thus, stimulus aspects that affect detection may differ from those that affect recognition; if a common representation serves both, it functions differently in the 2 cases.     

The myth of the encoding-retrieval match

Modern memory researchers rely heavily on the encoding-retrieval match, defined as the similarity between coded retrieval cues and previously encoded engrams, to explain variability in retention. The encoding-retrieval match is assumed to be causally and monotonically related to retention, although other factors (such as cue overload) presumably operate in some circumstances. I argue here that the link between the encoding-retrieval match and retention, although generally positive, is essentially correlational rather than causal--much like the link between deep/elaborative processing and retention. Empirically, increasing the functional match between a cue and a target trace can improve, have no effect, or even decrease retention performance depending on the circumstance. We cannot make unequivocal predictions about retention by appealing to the encoding-retrieval match; instead, we should be focusing our attention on the extent to which retrieval cues provide diagnostic information about target occurrence.     

Spatial learning and memory is preserved in rats after early development in a microgravity environment

This study evaluated the cognitive mapping abilities of rats that spent part of their early development in a microgravity environment. Litters of male and female Sprague-Dawley rat pups were launched into space aboard the National Aeronautics and Space Administration space shuttle Columbia on postnatal day 8 or 14 and remained in space for 16 days. These animals were designated as FLT groups. Two age-matched control groups remained on Earth: those in standard vivarium housing (VIV) and those in housing identical to that aboard the shuttle (AGC). On return to Earth, animals were tested in three different tasks that measure spatial learning ability, the Morris water maze (MWM), and a modified version of the radial arm maze (RAM). Animals were also tested in an open field apparatus to measure general activity and exploratory activity. Performance and search strategies were evaluated in each of these tasks using an automated tracking system. Despite the dramatic differences in early experience, there were remarkably few differences between the FLT groups and their Earth-bound controls in these tasks. FLT animals learned the MWM and RAM as quickly as did controls. Evaluation of search patterns suggested subtle differences in patterns of exploration and in the strategies used to solve the tasks during the first few days of testing, but these differences normalized rapidly. Together, these data suggest that development in an environment without gravity has minimal long-term impact on spatial learning and memory abilities. Any differences due to development in microgravity are quickly reversed after return to earth normal gravity.     

Motivation in later life: personal projects and well-being

"Personal projects," as defined by B. R. Little (1983), were elicited from 600 community residents aged 70+, representing a broad range of health and illness. Factor analysis revealed 6 types of personal projects: activities of daily living, active recreation, other-oriented activities, intellectual activities, home planning, and spiritual moral activities. Background factors and health were shown to affect the number and type of projects reported. Most indices of personal projects were associated with positive affect and valuation of life. Only 1 was associated with depression. This confirms the differential association of personal projects to positive but not negative affect. Personal projects are seen as part of an open motivational system in which social position, cognitive ability, health, and positive mental health are mutually interacting members.     

Automaticity in reading and the Stroop task: testing the limits of involuntary word processing

We investigated the parameters of involuntary word reading in the Stroop task in 7 experiments. Experiments 1-4 varied response modality and the presence of congruent word trials in a test of the claim that presenting a Stroop color word with only one letter in the target color eliminates the Stroop effect. Experiments 5 and 6 addressed the roles of spatial attention and orthographic processing as possible mechanisms behind the reduction of Stroop effects with the single-letter format. Experiment 7 investigated the limits of involuntary reading under optimal conditions for selective processing of rectangular color patch targets. We found that the single-letter format reduced but never eliminated Stroop effects, spatial attention but not orthographic processing plays a role in the effect of the single-letter format, and word reading is not completely prevented even with austere presentation conditions. We conclude with a defense of the involuntariness criterion for automaticity in the Stroop task, particularly when word reading is viewed in the context of a skilled performance.     

Safety behavior can hamper the extinction of fear of movement-related pain: An experimental investigation in healthy participants

Excessive fear of movement-related pain (FMRP), and its associated avoidance behavior, is considered a major risk factor for disability in chronic musculoskeletal pain. The current study aimed to investigate whether engaging in safety behavior, conceptualized as an avoidance response, hampers the extinction of FMRP. In a differential conditioning paradigm, we used joystick movements as conditioned stimuli (CSs) and a painful electrocutaneous stimulus as the unconditioned stimulus (US). In the Safety group, participants received the opportunity to avoid the pain-US by pressing a safety button during the extinction phase, whereas in the Control group, this option was not included. In a subsequent test phase, this safety button was no longer available. In two experiments, results demonstrate successful acquisition and extinction. Retrospective FMRP ratings in both experiments revealed a return of fear of pain in the test phase in the Safety group, but not in the Control group. In Experiment 1, mean eyeblink startle reflex amplitudes partly corroborated the self-report findings on fear of pain. The present results suggest that performing safety behavior during cognitive-behavioral interventions, i.e., exposure, might increase the risk of a return of FMRP.