Clinical perspectives on the combination of D-cycloserine and cognitive-behavioral therapy for the treatment of anxiety disorders

In a particular success for translational research agendas, characterization of the neuronal circuits underlying fear extinction, and basic research in animal extinction paradigms, has led to intervention studies examining the use of D-cycloserine (DCS) to enhance therapeutic learning from exposure-based cognitive-behavioral therapy (CBT). In this article, we review these intervention studies, and discuss DCS augmentation of CBT relative to more traditional combination-treatment strategies in the treatment of anxiety disorders. We offer an accounting, based on evidence for internal context effects, of current limitations in the combination of antidepressant or benzodiazepine medications with CBT and discuss the advantages of isolated-dosing strategies with DCS relative to these limitations. This strategy is contrasted with the chronic-dosing applications of DCS for schizophrenia and Alzheimer's disease, and future directions for isolated-dosing strategies are discussed.     

Effects of trophic poisoning with methylmercury on the appetitive elements of the agonistic sequence in fighting-fish (Betta splendens)

The aggressive display in Betta splendens is particularly prominent, and vital to its adaptation to the environment. Methylmercury is an organic variation of Hg that presents particularly pronounced neuro-behavioral effects. The present experiments aim to test the effect of acute and chronic poisoning with methylmercury on the display in Bettas. The animals were poisoned by trophic means in both experiments (16 ug/kg in acute poisoning; 16 ug/kg/day for chronic poisoning), and tested in agonistic pairs. The total frequency of the display was recorded, analyzing the topography of the agonistic response. The methylmercury seems to present a dose- and detoxification-dependent effect on these responses, with a more pronounced effect on motivity in acute poisoning and on emotionality in the chronic poisoning. It is possible that this effect could be mediated by alteration in the mono-amino-oxidase systems.     

Identifying and analyzing the construction and effectiveness of offensive plays in basketball by using systematic observation

In the field of sports research, there is a growing need for the rigorous collection of data that provide empirical evidence about the complex reality they refer to. Although sports psychology research has advanced considerably in recent years, in both extent and quality, one area of research that remains relatively unexplored is the dynamics of the sports group and the influence of the group on its members (George & Feltz, 1995; Widmeyer, Brawley, & Carron, 1992). Key aspects in this regard include the presence of regularities that are not detectable through visual inference or traditional methods of data analysis, the lack of standard observation instruments, and, assuming priority, the need to develop powerful, computerized coding systems, all of which must form part of an approach that is suitable for natural and habitual contexts. The present study is part of a broader research project concerning ACB teams (first Spanish basketball division) and considers the interaction context before teams try to score (where this is understood as how teams create scoring opportunities) as the core aspect that links team play. This investigation proposes a new model of analysis for studying the effectiveness and construction of offensive basketball plays in order to identify their outcomes, thus providing coaches with an important device for improving or consolidating them.     

Familiarity impacts person perception

We investigated the effects of familiarity on person perception. We predicted that familiarity would increase non‐analytic processing, reducing attention to and the impact of individuating information, and increasing the impact of category labels on judgments about a target person. In two studies participants read either incriminating or exculpatory individuating information about a defendant in a criminal case and made judgments of guilt. In Study 1, participants were subliminally exposed to the defendant's photo, another matched photo, or no photo before seeing the evidence. Participants familiar with the defendant's photo both processed and used the individuating information less. In Study 2, participants were subtly made familiar or not with the incriminating and exculpatory information itself, and the defendant was described either as a priest or as a skinhead. Familiarity with the information reduced attention to its content and also tended to increase reliance on category information in guilt judgments. Copyright © 2006 John Wiley & Sons, Ltd.     

Developing operating principles for systems change

Based on an analysis of the articles in this special issue, the authors propose five operating principles for systems change work. These principles are: clarifying the purpose of the systems change; identifying whether the change is one to an existing system or the change is to create a new system; conceptualize the work as systems change from the beginning; use an eclectic approach; and be open to opportunities that emerge while also undertaking forma analysis to identify leverage points. The authors argue that the time is now ripe to develop such principles and encourage community change agents to engage in a dialogue to explore, revise, eliminate or expand on these principles.     

Cognitive euroscience: Scalar variability in price estimation and the cognitive consequences of switching to the euro

The present paper examines the ability to evaluate prices in a familiar currency (French francs, Portugese escudos, or Irish punt) and in an unfamiliar currency (euro). Participants evaluated prices for different items either by selecting the most appropriate price from a set of alternatives (in a timed or not-timed version) or by directly producing a price estimate for each item. The results followed Weber's law: The standard deviation of estimated prices was proportional to their mean. The Weber fraction was stable for the familiar currency in different countries, but was significantly higher for the unfamiliar currency. We suggest that price estimation relies on a learned mapping between items and their prices as represented by distributions of activation on an internal number line. The observed Weber fraction reflects the degree of expertise with a given currency as well as a minimal variability intrinsic to the number line itself.     

Dissociations among memory measures in memory-impaired subjects: Evidence for a processing account of memory

Deficits in conceptual transfer on both implicit and explicit memory tests were obtained for memory-impaired temporal lobe epileptic (TLE) subjects in three studies. In Experiment 1, in which a generate-read paradigm was employed, memory-impaired TLEs failed to show normal generation effects on conceptually driven tests of semantic cued recall and general knowledge questions, although their data-driven memory as measured by word-fragment completion and graphemic cued recall tasks was normal. In Experiment 2, memory-impaired patients having left temporal lobe seizure foci were tested on these four tasks and compared with nonimpaired TLEs having right temporal foci. The left TLEs showed deficits on conceptually driven tasks and normal memory for data-driven tests. These findings were extended in Experiment 3, in which left TLE patients failed to show any benefit from blocked study, as compared with random study, on category production and semantic cued-recall tests, although right TLEs and normal controls showed blocking effects on both tasks. These findings may be accommodated by a processing framework of memory in which memory-impaired patients are characterized as having deficits in conceptual, but not in data-driven, processing capabilities.