Newborn screening for fragile X syndrome

Newborn screening for fragile X syndrome (FXS) is technically possible, and in the relatively near future accurate and inexpensive screening technologies are likely to be available. When that happens, will America's public health system adopt newborn screening for fragile X syndrome? This article addresses this issue by first placing screening for FXS in the context of the history and current status of newborn screening policy and practice. Lack of a proven medical treatment may stand as a barrier to newborn screening, but strong arguments can be made that early intervention provides important services for identified newborns and their families. Furthermore, other arguments could be used to justify newborn screening, including informed reproductive risk, medically necessary information, and consumer demand. Fragile X syndrome is offered as a prototype for many of the issues that will face society as more genetic disorders are discovered and new technologies for screening are developed.     

Playing with Dreams: The Introduction of a Third Party into the Transference Dynamic of the Couple

Dreams in couple therapy are expressions of the multiple discontinuous selves of partners and of interpersonal defenses. Two dreams offered during analytic couple therapy illustrate the use of transference and countertransference to observe disturbances in self-cohesion, communication of self-states, and attempts to affectively influence the partner. Dreams transferentially communicate the state of the realtionship, activate a third formation expressing shared pathology, and facilitate the growth of new aspects of the self seeking a more loving bond.     

ON THE EFFECTS OF NONCONTINGENT DELIVERY OF DIFFERING MAGNITUDES OF REINFORCEMENT

We conducted a parametric analysis of response suppression associated with different magnitudes of noncontingent reinforcement (NCR). Participants were 5 adults with severe or profound mental retardation who engaged in a manual response that was reinforced on variable-ratio schedules during baseline. Participants were then exposed to NCR via multielement and reversal designs. The fixed-time schedules were kept constant while the magnitude of the reinforcing stimulus was varied across three levels (low, medium, and high). Results showed that high-magnitude NCR schedules produced large and consistent reductions in response rates, medium-magnitude schedules produced less consistent and smaller reductions, and low-magnitude schedules produced little or no effect on responding. These results suggest that (a) NCR affects responding by altering an establishing operation (i.e., attenuating a deprivation state) rather than through extinction, and (b) magnitude of reinforcement is an important variable in determining the effectiveness of NCR.     

Object individuation in young infants: Further evidence with an event-monitoring paradigm

Recent results indicate that, when tested with an event-monitoring task, 7.5- and 9.5-month-olds give evidence that they can individuate objects in different-objects occlusion events – events in which two distinct objects appear successively on either side of an occluder (Wilcox and Baillargeon, in press). The present research sought to confirm and extend these findings. The experiments examined 7.5- and 4.5-month-olds’ ability to correctly interpret a different-objects (ball-box condition) and a same-object (ball-ball condition) occlusion event. The infants in the ball-box condition saw a test event in which a ball disappeared behind the left edge of a screen; after a pause, a box emerged from behind the screen's right edge. For half of the infants (wide-screen event), the screen was wide and could occlude the ball and box simultaneously; for the other infants (narrow-screen event), the screen was narrow and should not have been able to occlude the ball and box at the same time. The infants in the ball-ball condition saw identical wide- and narrow-screen events except that the ball appeared on both sides of the screen. The infants in the ball-box condition looked reliably longer at the narrow- than at the wide-screen event, whereas those in the ball-ball condition tended to look equally at the events. These results suggest that the ball-box infants (a) were led by the featural differences between the ball and box to view them as distinct objects; (b) judged that the ball and box could both be occluded by the wide but not the narrow screen; and (c) were surprised in the narrow-screen event when this judgment was violated. In contrast, the ball-ball infants (a) assumed, based on the featural similarities of the balls that appeared on either side of the screen, that they were one and the same ball, and (b) realized that the ball could be occluded by either the wide or the narrow screen. These results indicate that, by 4.5 months of age, infants are able to use featural information to correctly interpret different-objects and same-object occlusion events. These findings are discussed in the context of the newly-drawn distinction between event-monitoring and event-mapping paradigms (Wilcox and Baillargeon, in press).     

Teaching young adults with developmental disabilities and visual impairments to use tape-recorded recipes: Acquisition,generalization, and maintenance of cooking skills

Three young adults with developmental disabilities and visual impairments were taught to prepare three different recipes using tape-recorded instructions. Following instruction on each trained recipe, generality probes to untrained recipes were conducted. A multiple baseline across behaviors (recipes) design was used to determine the extent to which each student's preparation of untrained recipes improved as a function of being trained to prepare related recipes by using a self-operated audio prompting system. Results showed that students' cooking skills acquired through instruction on the trained recipes generalized (a) to untrained recipes requiring similar skills (simple generality) and (b) to more complex untrained recipes requiring a combination of skills learned during the instruction of two trained recipes (complex generality).     

Adaptive behavior of retarded,slow-learner,and average intelligence children

Scores on the WISC-R and the AAMD Adaptive Behavior Scale, Part I, Public School Version, were obtained for 94 elementary school children referred for psychological services in a southeastern rural area. Some of the adaptive behavior scores differentiated among children classified as EMR, slow-learners, or average intelligence. Some of the domain subscores of the ABS seem of questionable validity and reliability.     

Competitive behavior: A manifestation of motivation for ability comparison

Social comparison theory predicts that when the person is uncertain about the level of his ability, he may seek comparison information through competitive behavior. This derivation, however, has never been directly tested. An experiment is reported in which the level of the subject's uncertainty about his competence was manipulated and subsequent measures of his competitive motivation and behavior were obtained. The data indicate that higher levels of uncertainty do lead to higher levels of motivation and competition, but only under conditions that minimize threat to self-esteem.     

STIMULUS OVERSELECTIVITY IN LEARNING DISABLED CHILDREN

Stimulus overselectivity, a phenomenon exhibited by autistic and institutionalized retarded individuals, was examined in mildly handicapped and nonhandicapped public school children. Subjects were 16 young, educable mentally retarded, 16 learning disabled, 15 nonhandicapped first- and second-graders, and 16 older, educable retarded students. The children were trained on a 3-component visual discrimination task and then tested on individual elements to determine which element or elements were controlling subject responses. Nine of the young educable mentally retarded children and eight of the learning disabled students showed some overselectivity. The majority of overselective retarded children were controlled by only one of the three components of the training cue, whereas the majority of the overselective learning disabled children responded to the discrimination task on the basis of two of the three components. No overselectivity was exhibited by the nonhandicapped students. All three cue components were also functional in controlling the responding of 14 of the 16 older retarded students, but two children were under the control of only one cue. The research indicated that in terms of overselectivity, learning disabled children respond more like young, mildly retarded children than they do like nonhandicapped ones. The demonstration of stimulus overselectivity in a sizable portion of a learning disabled sample may have implications for a more empirically based approach to this handicapped population.     

THE MODIFICATION OF LEISURE BEHAVIOR IN A HALF-WAY HOUSE FOR RETARDED WOMEN1

A multi-element baseline design combined with a multiple-baseline design, was used to investigate the effect of availability of materials, prizes for participation, and instruction on the leisure behavior of 14 mentally retarded women in a half-way house. A leisure program was conducted on weekday evenings, during which residents could choose to participate in any of six activities offered: puzzles, card games, clay, painting, weaving, and rug making. It was found that instruction in weaving and rug making significantly increased the percentage of residents participating in these activities, and that following instruction, prizes were not necessary to maintain high levels of participation. In contrast, prizes were more effective than mere availability of materials in maintaining participation in the other activities.     

AN ANALYSIS OF ERROR-CORRECTION PROCEDURES DURING DISCRIMINATION TRAINING

Mechanisms involved in error-correction procedures during behavioral acquisition were examined. Seven developmentally delayed subjects participated in match-to-sample discrimination training, consisting of three conditions arranged in a multielement design. Correct responses in all conditions were followed by praise and either food or pennies. In the baseline condition (differential reinforcement), an error produced no consequences. In the practice condition, an error was followed by repetition of the trial until a correct response occurred. In the avoidance condition, an error was followed by additional trials consisting of irrelevant stimuli; this condition separated the effects of repeated exposure to the same task from those of negative reinforcement, both of which existed in the practice condition. All 7 subjects made noticeable progress in the baseline condition. However, 5 of the 7 performed better in one of the error-correction conditions: 2 performed better in the practice condition, and 3 performed better in the avoidance condition. These data indicate that error-correction procedures may serve multiple functions and suggest that the practice requirement in this study included both avoidance and stimulus control components. More generally, the data indicate that additional control procedures should be included in acquisition studies to identify the relevant behavioral mechanism(s).