Hormonal regulation of delta opioid receptor immunoreactivity in interneurons and pyramidal cells in the rat hippocampus

Clinical and preclinical studies indicate that women and men differ in relapse vulnerability to drug-seeking behavior during abstinence periods. As relapse is frequently triggered by exposure of the recovered addict to objects previously associated with drug use and the formation of these associations requires memory systems engaged by the hippocampal formation (HF), studies exploring ovarian hormone modulation of hippocampal function are warranted. Previous studies revealed that ovarian steroids alter endogenous opioid peptide levels and trafficking of mu opioid receptors in the HF, suggesting cooperative interaction between opioids and estrogens in modulating hippocampal excitability. However, whether ovarian steroids affect the levels or trafficking of delta opioid receptors (DORs) in the HF is unknown. Here, hippocampal sections of adult male and normal cycling female Sprague-Dawley rats were processed for quantitative immunoperoxidase light microscopy and dual label fluorescence or immunoelectron microscopy using antisera directed against the DOR and neuropeptide Y (NPY). Consistent with previous studies in males, DOR-immunoreactivity (-ir) localized to select interneurons and principal cells in the female HF. In comparison to males, females, regardless of estrous cycle phase, show reduced DOR-ir in the granule cell layer of the dentate gyrus and proestrus (high estrogen) females, in particular, display reduced DOR-ir in the CA1 pyramidal cell layer. Ultrastructural analysis of DOR-labeled profiles in CA1 revealed that while females generally show fewer DORs in the distal apical dendrites of pyramidal cells, proestrus females, in particular, exhibit DOR internalization and trafficking towards the soma. Dual label studies revealed that DORs are found in NPY-labeled interneurons in the hilus, CA3, and CA1. While DOR colocalization frequency in NPY-labeled neuron somata was similar between animals in the hilus, proestrus females had fewer NPY-labeled neurons that co-labeled with DOR in stratum oriens of CA1 and CA3 when compared to males. Ultrastructural analysis of NPY-labeled axon terminals within stratum radiatum of CA1 revealed that NPY-labeled axon terminals contain DORs that are frequently found at or near the plasma membrane. As no differences were noted by sex or estrous cycle phase, DOR activation on NPY-labeled axon terminals would inhibit GABA release probability equally in males and females. Taken together, these findings suggest that ovarian steroids can impact hippocampal function through direct effects on DOR levels and trafficking in principal cells and broad indirect effects through reductions in DOR-ir in NPY-labeled interneurons, particularly in CA1.     

Spiritual well-being and spiritual practices in elderly depressed psychiatric inpatients

This study's aims were to describe the spirituality of depressed elderly psychiatric inpatients and to examine associations among spirituality, depression, and quality of life (QOL). Forty-five persons participated. Most reported frequent, stable spiritual practices and experiencing spiritual comfort and guidance. Some reported spiritual distress and changes in spirituality. During hospitalization, participants demonstrated increased spiritual well-being (SWB) and peacefulness, and reduced hopelessness, worthlessness, and guilt. Positive associations were found between SWB and QOL and negative associations between SWB and depression.     

A preliminary examination of the effect of massage on state body image

Evidence suggests positive effects of massage on psychological health; however, little is known about the effects of massage on body image. This research examined the effect of massage on state body image as well as relations between trait body image and attitudes toward massage. Forty-nine female university students were randomly assigned to either a massage condition or a control condition. It was hypothesized that participants in the massage condition would report improved state body image following the intervention when compared to participants in the control condition. As predicted, participants in the massage condition reported a more favorable state body image than participants in the control condition post-manipulation. Certain body image evaluations were moderately associated with views that massage is pleasurable, with the link between Body Areas Satisfaction and viewing massage as pleasurable reaching significance. Research is needed to determine the mechanism/s through which massage improves body image.     

Behavioral community psychology: training a community board to problem solve

This study demonstrated the effect of training nine lower socio-economic adults participating as policy board members in a federally funded rural community project to make behaviorally defined statements to increase problem-solving behaviors in board meetings. A multiple-baseline design across subjects and skills was used to analyze the behavioral categories of: (1) stating the problem; (2) finding solutions to the problem, and (3) implementing the action to the solution. Problem-solving responses during board meetings increased for subjects following training and remained higher than baseline during follow-up.     

Operant psychology goes to the fair: Marian and Keller Breland in the popular press, 1947-1966

Marian and Keller Breland pioneered the application of operant psychology to commercial animal training during the 1940s and 1950s. The Brelands' story is relatively unknown in the history of behavior analysis. Using information from the Breland-Bailey papers, this paper describes the development and activities of Animal Behavior Enterprises (ABE), the Brelands' animal training business. We also review popular press coverage of the Brelands between 1947 and 1966 to investigate the level of public exposure to ABE-trained animals and to the principles and methods of operant psychology. An examination of 308 popular print articles featuring the Brelands indicates that there was public exposure of behavior analysis through the popular press coverage of ABE-trained animals. Furthermore, the expansion of operant methods to the marine mammal and bird training industries can be linked to the Brelands' mass media exposure.     

Mothers' beliefs about listening: Implications for children's comprehension and conceptions of listening

Forty-four mothers offered their beliefs about listening and methods for encouraging listening in their 3- to 5-year-old children. Children's comprehension performance and conceptions of listening were also obtained. Mother perceived themselves as the primary agent responsible for children's development of basic listening competencies, such as figuring out the main point of what someone said to them, not interrupting others, and asking a question of the speaker when confused. Children who had strong comprehension skills had mothers who believed that listening is a complex set of activities, emphasized their own responsibility in ensuring that their children develop basic listening competencies, stressed comprehension processes and question asking in their conceptions of listening and in their techniques for enhancing children's listening, and began reading to their children at an early age.     

On the Robustness of Outcome Bias: No Constraint by Prior Culpability

Research on outcome bias has shown that blame attributions for behavioral decisions depend on the decision's consequences. Five studies of American undergraduates (N = 219, N = 83, N = 62, N = 279, and N = 45, respectively) demonstrated robust outcome effects across a variety of circumstances. A manipulation of prior negligence (Study 1), and attempts to keep prior negligence exceedingly low (Studies 2-4) produced converging results. In Study 5, a within-participants manipulation failed to eradicate outcome effects. Furthermore, outcome effects were not moderated by beliefs in a just world. Across all studies, mediational analyses suggested that participants adjusted estimates of negligence to match outcomes, which in turn led to more outcome-consistent attributions of blame. Study 5 showed that those low in belief in a just world were especially likely to adjust their negligence ratings in this way. These studies demonstrate that outcome effects contravene both the standards for rationality delineated by rational decision theorists, and also the more relaxed standards embodied in established legal doctrine.     

Similarity-based interference in a working memory numerical updating task: age-related differences between younger and older adults

Similarity among representations held simultaneously in working memory (WM) is a factor which increases interference and hinders performance. The aim of the current study was to investigate age-related differences between younger and older adults in a working memory numerical updating task, in which the similarity between information held in WM was manipulated. Results showed a higher susceptibility of older adults to similarity-based interference when accuracy, and not response times, was considered. It was concluded that older adults' WM difficulties appear to be due to the availability of stored information, which, in turn, might be related to the ability to generate distinctive representations and to the process of binding such representations to their context when similar information has to be processed in WM.     

The Relation Between Co-rumination, Maternal Depressive Symptoms and Child Psychopathology

Little is known about which processes explain the well-established link between maternal and child symptomatology. Interpersonal coping processes may be worth exploring, as depressed mothers have characteristic coping styles that may influence interactions with their children. We examined two interpersonal coping processes as potential factors explaining how depressive symptomatology in mothers impacts child psychopathology: parent-child co-rumination (dwelling on negative affect, over-analyzing problems) and impaired problem-solving. We analyzed 198 aggressive children (most of whom also had elevated internalizing symptoms) who engaged in structured discussions with their mothers. Coders rated the extent to which dyads problem-solved and co-ruminated during discussions, and mothers filled out questionnaires assessing maternal and child symptoms. Path analysis tested whether higher levels of co-rumination and poor problem-solving statistically mediated the relation between depressive symptoms in mothers and child internalizing and externalizing behaviour. Maternal depressive symptomatology was correlated with greater child symptoms, higher rates of co-rumination and poorer problem-solving. Statistical mediation was non-significant. Results support the established link between maternal depression and child psychopathology, and suggest that dysphoric mothers and their children engage in maladaptive coping interactions.