Electrodermal responses to attended and nonattended significant stimuli during dichotic listening

Some investigators have found that words previously associated with shock elicit electrodermal responses (EDRs) when presented in the nonattended channel of a dichotic listening task. The present experiment tested for this phenomenon while closely monitoring for shifts in attention to the nonattended channel. College student volunteers verbally shadowed a series of unrelated words presented to the attended channel while words made significant by previous association with shock (and semantically related words) were occasionally presented to the nonattended channel. Three principal findings were obtained. Fist, when EDRs were averaged across all trials and across all subjects, it was found that EDRs were elicited by the significant words presented in the nonattended channel. Second, for the subgroup of subjects that had the significant words presented to the right ear (activating the left cerebral hemisphere), it was found that EDRs were elicited by the significant words presented to the left ear (activating the right cerebral hemisphere), it was found that EDRs were elicited by the significant word seven on trials on which there were no apparent shifts in attention. The results of this study indicate the importance of closely controlling and monitoring for shifts in attention and suggest the potential importance of cerebral laterality in mediating EDRs to stimuli presented in a nonatttended channel.     

Volume Contents

Volume Contents

Volume Contents     

The effects of age upon the perception of depth and 3-D shape from differential motion and binocular disparity

The ability of younger and older adults to perceive the 3-D shape, depth, and curvature of smooth surfaces defined by differential motion and binocular disparity was evaluated in six experiments. The number of points defining the surfaces and their spatial and temporal correspondences were manipulated. For stereoscopic sinusoidal surfaces, the spatial frequency of the corrugations was also varied. For surfaces defined by motion, the lifetimes of the individual points in the patterns were varied, and comparisons were made between the perception of surfaces defined by points and that of more ecologically valid textured surfaces. In all experiments, the older observers were less sensitive to the depths and curvatures of the surfaces, although the deficits were much larger for motion-defined surfaces. The results demonstrate that older adults can extract depth and shape from optical patterns containing only differential motion or binocular disparity, but these abilities are often manifested at reduced levels of performance.     

The effects of universal pre-K on cognitive development

In this study of Oklahoma's universal pre-K program, the authors relied on a strict birthday eligibility criterion to compare "young" kindergarten children who just completed pre-K to "old" pre-K children just beginning pre-K. This regression-discontinuity design reduces the threat of selection bias. Their sample consisted of 1,567 pre-K children and 1,461 kindergarten children who had just completed pre-K. The authors estimated the impact of the pre-K treatment on Woodcock-Johnson Achievement test scores. The authors found test impacts of 3.00 points (0.79 of the standard deviation for the control group) for the Letter-Word Identification score, 1.86 points (0.64 of the standard deviation of the control group) for the Spelling score, and 1.94 points (0.38 of the standard deviation of the control group) for the Applied Problems score. Hispanic, Black, White, and Native American children all benefit from the program, as do children in diverse income brackets, as measured by school lunch eligibility status. The authors conclude that Oklahoma's universal pre-K program has succeeded in enhancing the school readiness of a diverse group of children.     

Development of subtype selective GABAA modulators

Drugs modulating gamma-aminobutyric acid (GABA) transmission via the benzodiazepine (BZ) site on the gamma-aminobutyric acid type A (GABAA) receptor have been in widespread use for more than 40 years to treat anxiety, epilepsy, and sleep disorders. These drugs have been shown to be safe, well tolerated, and effective although the mechanism by they produce a myriad of pharmacologic effects remains elusive. In recent years it has been discovered that, although the GABAA receptor is widely distributed in the brain, the substructure and composition of the receptor differs from between brain regions. Termed "GABAA receptor subtypes" their discovery leads to speculation that different subtypes may mediate specific effects of BZs such as anxiety or sedation. The phenotypic analysis of transgenic knock-in and knock-out mice in which particular GABAA receptors were rendered insensitive to the effects of BZ while others were unaffected confirmed this speculation. Subsequently, subtype-specific GABAA ligands were developed that, for example, retained the anxiolytic effects of BZs but were devoid of their sedative effects. Therefore, it may be possible to develop effective anxiolytic compounds that have a much reduced side-effect profile compared with existing drugs.     

Levels of interpersonal complementarity: a simplex representation

The relations among different measures of interpersonal behavior and complementarity across level were examined in one session of a sample of therapy dyads (N = 26) and in an interaction between college students (N = 108). Four levels of complementarity, trait, aggregate situation, behavioral interchanges, and behavioral interchanges with base rates removed were examined as they covaried among themselves and with interaction evaluations. The four levels of complementarity were found to be fit by a simplex structure, and this structure was related to interaction evaluation in both samples. The complementarity-evaluation relation was mediated by base-rate-corrected complementarity. Implications relative to the operationalization of complementarity are discussed.     

New anticonvulsant medication uses in bipolar disorder

Therapy of bipolar disorders is a rapidly evolving field. Lithium has efficacy in classic bipolar disorders whereas divalproex sodium and carbamazepine may have broader spectrum efficacy that includes non-classic bipolar disorder. In the last 10 years, a series of anticonvulsants have been approved for marketing in the United States. Gabapentin has indirect g-aminobuytric acid-ergic actions, is generally well tolerated, and appears to have anxiolytic, analgesic, and hypnotic effects. Lamotrigine has antiglutamatergic actions and is generally well tolerated (aside from rash in 1 in 10, and serious rash in 1 in 1,000 patients). Lamotrigine is indicated for maintenance treatment in bipolar disorder. Emerging evidence suggests lamotrigine may have utility in bipolar disorder patients with depression and treatment-refractory rapid cycling, as well as analgesic effects. Topiramate and zonisamide may allow both weight loss, while topiramate may have specific efficacy in bulimia, binge eating disorder, and alcohol dependence. Two small studies found oxcarbazepine had similar efficacy to lithium and haloperidol in acute mania. Phenytoin, an older anticonvulsant, may have adjunctive acute mania efficacy. Levetiracetam, a newer anticonvulsant, may be worth exploring and has minimal drug-drug interactions. None of these newer agents has been shown effective in a large placebo controlled trial for acute mania. Although the clinical profiles of these newer anticonvulsants do not appear to overlap markedly with divalproex and carbamazepine (except perhaps for oxcarbazepine), these novel agents may still offer important new options in relieving a variety of specific target symptoms in patients with bipolar disorder.