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Oliver Stiedl Michael Meyer MD PhD 《Integrative psychological & behavioral science》2002,37(4):311-345
Non-linear fractal analysis of cardiac interbeat time series was performed in corticotropin-releasing factor receptor subtype
2 (CRFR2) deficient mice. Heart rate dynamics in mice constitutes a self-similar, scale-invariant, random fractal process
with persistent intrinsic long-range correlations and inverse power-law properties. We hypothesized that the sustained tachycardic
response elicited by intraperitoneal (ip) injection of human/rat CRF (h/rCRF) is mediated by CRFR2. In wildtype control animals,
heart rate was increased to about maximum levels (~ 750 bpm) while in CRFR2-deficient animals baseline values were retained
(~ 580 bpm). The tachycardic response elicited by ip-application is mediated by CRFR2 and is interpreted to result from sympathetic
stimulation. However, the functional integrity of CRFR2 would not present a prerequisite to maintaining the responsiveness
and resiliency of cardiac control to external environmental perturbations experimentally induced by extrinsic ip-application
of h/rCRF or under physiological conditions that may be associated with an increased peripheral release of CRF. Under stressful
physiological conditions achieved by novelty exposure, CRFR2 is not involved in the cardiodynamic regulation to external short-term
stress. While the hypothesis of involvement of CRFR2 in cardiac regulation upon pharmacological stimulation cannot be rejected,
the present findings suggest that the mechanism of action is by sympathetic stimulation, but would not unambiguously allow
to draw any conclusions as to the physiological role of CRFR2 in the control of cardiac dynamics. 相似文献
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Evaluation of the 113Online Suicide Prevention Crisis Chat Service: Outcomes,Helper Behaviors and Comparison to Telephone Hotlines 下载免费PDF全文
Jan K. Mokkenstorm MD Merijn Eikelenboom LLM Annemiek Huisman PhD Jasper Wiebenga MSc Renske Gilissen PhD Ad J. F. M. Kerkhof PhD Johannes H. Smit PhD 《Suicide & life-threatening behavior》2017,47(3):282-296
Recognizing the importance of digital communication, major suicide prevention helplines have started offering crisis intervention by chat. To date there is little evidence supporting the effectiveness of crisis chat services. To evaluate the reach and outcomes of the 113Online volunteer‐operated crisis chat service, 526 crisis chat logs were studied, replicating the use of measures that were developed to study telephone crisis calls. Reaching a relatively young population of predominantly females with severe suicidality and (mental) health problems, chat outcomes for this group were found to be comparable to those found for crisis calls to U.S. Lifeline Centers in 2003–2004, with similar but not identical associations with specific helpers' styles and attitudes. Our findings support a positive effect of the 113Online chat service, to be enhanced by practice standards addressing an apparent lack of focus on the central issue of suicidality during chats, as well as by the development of best practices specific for online crisis intervention. 相似文献
177.
A Machine Learning Approach to Identifying the Thought Markers of Suicidal Subjects: A Prospective Multicenter Trial 下载免费PDF全文
John P. Pestian PhD Michael Sorter MD Brian Connolly PhD Kevin Bretonnel Cohen PhD Cheryl McCullumsmith MD PhD Jeffry T. Gee MD Louis‐Philippe Morency PhD Stefan Scherer PhD Lesley Rohlfs MS the STM Research Group 《Suicide & life-threatening behavior》2017,47(1):112-121
Death by suicide demonstrates profound personal suffering and societal failure. While basic sciences provide the opportunity to understand biological markers related to suicide, computer science provides opportunities to understand suicide thought markers. In this novel prospective, multimodal, multicenter, mixed demographic study, we used machine learning to measure and fuse two classes of suicidal thought markers: verbal and nonverbal. Machine learning algorithms were used with the subjects’ words and vocal characteristics to classify 379 subjects recruited from two academic medical centers and a rural community hospital into one of three groups: suicidal, mentally ill but not suicidal, or controls. By combining linguistic and acoustic characteristics, subjects could be classified into one of the three groups with up to 85% accuracy. The results provide insight into how advanced technology can be used for suicide assessment and prevention. 相似文献
178.
Alexei V. Shemagonov MD Valentina N. Sidorenko MD Ph.D. 《Integrative psychological & behavioral science》2000,35(3):218-223
The purpose of this investigation was to study the effects of Medical Resonance Therapy Music (MRT-Music) upon autonomous
innervation of cerebral arteries by examining slow spontaneous oscillations of cerebral blood flow (SSO) using transcranial
Doppler ultrasound (TCD). TCD detects SSO with 3–9 cycles per minute (M-waves) and 0.5–2 cycles per minute (B-waves). The
SSO are caused by rhythmic diameter changes of the medium and small cerebral arteries. Six patients aged 24–65 years suffering
from tension headache were treated with MRT-Music. Twelve additional patients were examined with TCD only to register SSO
for further spectral analysis.
After fast Fourier transformation four groups of peaks were registered on the SSO spectra, divided into four rhythms: A. 0.0–0.02
Hz, B. 0.02–0.033 Hz, C. 0.06–0.09 Hz, D. 0.09–0.15 Hz and an intermediate diapason of 0.034–0.059 Hz.
Spectral analysis of the SSO showed changes between initial and final amplitude peaks in all patients. In contrast to A-,
B-and D-rhythms, the reduction of peaks in the C-diapason was statistically significant (31–60%, P 3D0.04, CI 3D95%) for patients
treated with MRT-Music. All patients treated with the MRT-Music reported a relief of headache while and after treatment. 相似文献
179.
Music is an ancient method for healing. In the year 550 B.C., Pythagoras from Greece developed a concept for the use of music
in medicine, esteeming music higher than many other medical treatments. The Medical Resonance Therapy Music (MRT-Music) of
the German classical composer and musicologist Peter Huebner is built on this concept of Pythagorean music medicine. Its therapeutic
effect may be best explained by the natural phenomenon of resonance between the harmony laws of the microcosm of music and
the biological laws of the body. Results received after application of MRT-Music indicate multiple positive effects on the
organism of pregnant women both with a healthy pregnancy as with a pathologic one, reducing the rate of premature births very
effectively. Furthermore, MRT-Music came out to be an effective method in the complex therapy of late gestoses and a nearly
irreplaceable method for preoperative preparation of pregnant woman for caesarean section. It demonstrated a powerful anti-stress
effect and allowd to reduce the amount of administered pain-killers to pregnant women by the factor 1.5 to 2.0 thus reducing
the negative pharmacological load to the foetus. It furthermore reduced labour time and shortened hospital stay. It helped
to create optimal conditions for the course of pregnancy and heightened pain sensitivity threshold by means of improving the
functional, hormonal, and psycho-emotional conditions of pregnant and lying-in women. Thus, the labour process became more
natural, the delivery non-traumatic, and motherhood more happy and safe. 相似文献
180.
Thomas Forkmann PhD Anne Scherer Dipl‐Psych Maren Böcker PhD Markus Pawelzik MD Siegfried Gauggel PhD Heide Glaesmer PhD 《Suicide & life-threatening behavior》2014,44(5):524-536
The differential relations between the emotion regulation strategies “cognitive reappraisal” and “expressive suppression” and suicidality in a mixed inpatient sample (N = 232, 69.4% female) of a German psychotherapeutic hospital were examined. Patients filled in the Emotion Regulation Questionnaire and items on suicidal ideation and desire. A structural equation model fitted the data (RMSEA = .044; CFI = .96) and revealed that “expressive suppression” significantly predicted increased suicidal ideation. Moderation analysis showed that results were independent from a current depressive episode. Potential implications for psychotherapeutic treatment of suicidality are discussed. 相似文献