Cognitive effects of hormone therapy in early postmenopausal women

Recent reports suggest that hormone therapy (HT) with estrogen may have a protective effect on the ageing brain and cognitive function. However, clinical evidence regarding the cognitive effects in menopausal women under HT has produced conflicting results. The purpose of the present study was to assess and compare the cognitive effects after 6 months of HT in 30 early postmenopausal women, who were divided into three groups as follows: group I, Therapy conjugated equine estrogen (ET) CEE 0.625 mg/day (n = 10); group II, Estrogen‐Progestin Therapy (EPT), CEE 0.625 mg/day plus, chlormadinone 1 mg/day (n = 10); and group III, the control group, who did not receive treatment (n = 10). The three groups were matched by age and years of education. Exclusion criteria were: central nervous system diseases, severe cardiac disease, and clinical history of cancer and depression. Subjects were tested using a comprehensive battery for the evaluation of attention, memory and executive functions, which was standardized and validated in Spanish‐speaking subjects. The rate of cognitive change was defined by the difference between the measurements at the sixth month minus the baseline score. Mean group differences were assessed with MANOVA, followed by one‐way ANOVA considering statistical significance when p < .05; the alpha significance level .05 was corrected using the Bonferroni procedure. The EPT group showed higher scores than the control group and ET group in the Total Attention Score and in the copy of the Rey‐Osterreith Complex Figure. The ET group showed significantly higher scores than the control group and the EPT group in the subtest of Spatial Backward Span and in the Immediate Face Codification. The short‐term positive effects observed with HT in this sample could be related to the stimulation of brain receptors and/or neurotrophic factors that are still present at this age.     

Motivation to support a desired conclusion versus motivation to avoid an undesirable conclusion: The case of infra‐humanization

Social motivation has been shown to influence various cognitive processes. In the present paper, it is verified that people are motivated to view out‐groups as possessing a lesser degree of humanity than the in‐group (Leyens et al., 2000 ) and that this motivation influences logical processing in the Wason selection task. So far, studies on infra‐humanization have been shown to influence attribution of uniquely human characteristics to groups. Most of these studies focused on the attribution of secondary emotions. Results have shown that secondary emotions are preferentially attributed to in‐group members (Leyens et al., 2001 ). Also, people tend to react differently to in‐group and out‐group members displaying secondary emotions (Gaunt, Leyens, & Sindic, 2004 ; Vaes, Paladino, Castelli, Leyens, & Giovanazzi, 2003 ). In the present paper, it is argued that infra‐humanization is a two‐direction bias and that it does influence logical processing among perceivers. Specifically, infra‐humanization motivation impacts logical processing in two different directions. First, most motivation is spent to reach the desirable conclusion that the in‐group is uniquely human. Second, least motivation occurs to support the undesirable conclusion that the out‐group is uniquely human. These hypotheses are tested in four cross‐cultural studies that varied the status and the conflicting relations between groups. Results were in line with the predictions and further confirmed that infra‐humanization biases can be obtained independently of status and conflict (but see Cortes, Demoulin, Leyens, & de Renesse, 2005 ). The discussion relates these findings with in‐group favouritism and out‐group derogation (Brewer, 1999 ) and underlines the importance of infra‐humanization in counteracting system justification biases (Jost & Banaji, 1994 ).     

THE PHILOSOPHY OF JOSEPH MARGOLIS

Abstract: In this article I focus on some of Joseph Margolis's contributions to medical ethics. I first discuss some of Margolis's normative and metaphysical views on death and abortion, particularly in his early work Negativities , as well as some of his metaphysical assumptions. Then these views and assumptions are related to his theory of persons and, by implication, his theory of culture, set forth in a number of later works. In the course of the discussion, I call attention to some controversial issues of today, such as embryonic stem cell research and the creation of embryos for the sole purpose of research, and ask for Margolis's views on them, given his earlier contributions and assumptions. Finally, I comment on his relativism and his program for research in aesthetics and ethics.     

The lay distinction between primary and secondary emotions: A spontaneous categorization?

In line with the psychological essentialism perspective, Leyens et al. ( 13 2000) have hypothesized that people attribute different essences to groups and that they attribute more uniquely human characteristics to their own group than to out‐groups. Leyens et al. have focused on two types of emotions, which in Roman languages have specific labels, such as sentimientos and emociones in Spanish. A cross‐cultural study showed that sentimientos (or secondary emotions) are considered uniquely human emotions whereas emociones (or primary emotions) are perceived as nonuniquely human emotions. The present study focuses on whether this categorization into primary and secondary emotions is a spontaneous distinction that people use in their everyday lives, or whether, on the contrary, it is the result of experimental demands. The paradigm “Who says what to whom” was used to test this question. Geometrical shapes of different colours were systematically associated with different stimuli that varied in meaningfulness. In a first condition, shapes were associated with small or large items of furniture (meaningful categories) and with primary and secondary emotions. In a second condition, the items of furniture were replaced by words ending with a vowel or a consonant (meaningless categories). Subsequently, participants had to recognize which shape was associated with each stimulus. Intra‐category errors were significantly more numerous than inter‐category errors, except for the words ending with a vowel or a consonant. Stated otherwise, types of emotions were recognized like the meaningful difference between items of furniture. These results show that the distinction between primary and secondary emotions is an implicit one that people use spontaneously, and not as a result of task demands. The findings are discussed from the perspective of psychological essentialism and inter‐group relations.     

Facilitating children's accurate responses: conversational rules and interview style

This study examined the effectiveness of teaching young children a set of social conversational rules as a method of reducing errors in children's memory reports. Forty children (aged 3 to 6 years) interacted with a confederate ‘teaching assistant.’ Three conversational rules were examined as possible means of decreasing inaccuracies. For comparison purposes, three placebo rules were also developed. To test the limitations of teaching young children a set of conversational rules, three interview styles (neutral, repetitive, accusatory) were used. Results indicated that children who received all three target rules provided a smaller proportion of incorrect responses than did children who received fewer target rules or than children in a placebo control group, regardless of interview style. Theoretical and applied issues are discussed. Copyright © 2005 John Wiley & Sons, Ltd.     

On the Causal Completeness of Physics

According to an increasing number of authors, the best, if not the only, argument in favour of physicalism is the so‐called ‘overdetermination argument’. This argument, if sound, establishes that all the entities that enter into causal interactions with the physical world are physical. One key premise in the overdetermination argument is the principle of the causal closure of the physical world, said to be supported by contemporary physics. In this paper, I examine various ways in which physics may support the principle, either as a methodological guide or as depending on some other laws and principles of physics.     

Co‐development of child‐mother gestures over the second and the third years

This study looks at whether there is a relationship between mother and infant gesture production. Specifically, it addresses the extent of articulation in the maternal gesture repertoire and how closely it supports the infant production of gestures. Eight Spanish mothers and their 1‐ and 2‐year‐old babies were studied during 1 year of observations. Maternal and child verbal production, gestures and actions were recorded at their homes on five occasions while performing daily routines. Results indicated that mother and child deictic gestures (pointing and instrumental) and representational gestures (symbolic and social) were very similar at each age group and did not decline across groups. Overall, deictic gestures were more frequent than representational gestures. Maternal adaptation to developmental changes is specific for gesturing but not for acting. Maternal and child speech were related positively to mother and child pointing and representational gestures, and negatively to mother and child instrumental gestures. Mother and child instrumental gestures were positively related to action production, after maternal and child speech was partialled out. Thus, language plays an important role for dyadic communicative activities (gesture–gesture relations) but not for dyadic motor activities (gesture–action relations). Finally, a comparison of the growth curves across sessions showed a closer correspondence for mother–child deictic gestures than for representational gestures. Overall, the results point to the existence of an articulated maternal gesture input that closely supports the child gesture production. Copyright © 2006 John Wiley & Sons, Ltd.