Slow and steady: sustained effects of lexico-semantic associations can mediate referential impairments in schizophrenia

The present study investigated the contribution of lexico-semantic associations to impairments in establishing reference in schizophrenia. We examined event-related potentials as schizophrenia patients and healthy, demographically matched controls read five-sentence scenarios. Sentence 4 introduced a noun that referred back to three possible referents introduced in Sentences 1–3. These referents were contextually appropriate, contextually inappropriate but lexico-semantically associated, and contextually inappropriate and lexico-semantically nonassociated. In order to determine whether participants had correctly linked the anaphor to its referent, the final sentence reintroduced each referent, and participants indicated whether the last two sentences referred to the same entity. Results indicated that between 300 and 400 ms, patients, like healthy controls, used discourse context to link the noun with its preceding referent. However, between 400 and 500 ms, neural activity in patients was modulated only by lexico-semantic associations, rather than by discourse context. Moreover, patients were also more likely than controls to incorrectly link the noun with contextually inappropriate but lexico-semantically associated referents. These results suggest that at least some types of referential impairments may be driven by sustained activation of contextually inappropriate lexico-semantic associations.     

Non-conscious goal conflicts

The question raised in this paper is whether goal conflicts can occur outside of conscious awareness. Given the numerous and potentially conflicting goals people pursue, and the severe scarcity of mental resources, we offer a positive answer. Six experiments that employed a dissociation paradigm tested this hypothesis. Using three implicit behavioral markers of goal conflict (increased decision times, increased decision variance and heightened sensitivity to environmental information), and one physiological marker (increased arousal as measured by skin conductance level), these experiments document goal conflicts that do not reach conscious awareness.     

Caffeine enhances real-world language processing: evidence from a proofreading task

Caffeine has become the most prevalently consumed psychostimulant in the world, but its influences on daily real-world functioning are relatively unknown. The present work investigated the effects of caffeine (0 mg, 100 mg, 200 mg, 400 mg) on a commonplace language task that required readers to identify and correct 4 error types in extended discourse: simple local errors (misspelling 1- to 2-syllable words), complex local errors (misspelling 3- to 5-syllable words), simple global errors (incorrect homophones), and complex global errors (incorrect subject-verb agreement and verb tense). In 2 placebo-controlled, double-blind studies using repeated-measures designs, we found higher detection and repair rates for complex global errors, asymptoting at 200 mg in low consumers (Experiment 1) and peaking at 400 mg in high consumers (Experiment 2). In both cases, covariate analyses demonstrated that arousal state mediated the relationship between caffeine consumption and the detection and repair of complex global errors. Detection and repair rates for the other 3 error types were not affected by caffeine consumption. Taken together, we demonstrate that caffeine has differential effects on error detection and repair as a function of dose and error type, and this relationship is closely tied to caffeine's effects on subjective arousal state. These results support the notion that central nervous system stimulants may enhance global processing of language-based materials and suggest that such effects may originate in caffeine-related right hemisphere brain processes. Implications for understanding the relationships between caffeine consumption and real-world cognitive functioning are discussed.     

A developmental study of the role of word order in comprehending Hebrew

Monolingual Hebrew-speaking subjects, 3, 4, 5, 6, 7, and 11 years old, as well as adults, were asked to interpret utterances consisting of two nouns and a verb. Some utterances included only word order cues while others included direct object marker and subject-verb gender agreement cues. Even though Hebrew word order is relatively free, when subjects used word order as an interpretive cue they generally assigned sentence relations according to the dominant SVO order of modern Hebrew. This trend was less strong for the interpretations of NNV utterances than of NVN and VNN utterances. There was no evidence of a developmental sequence for word order strategies. In addition, there was no evidence that word order, for any age group, was necessarily a dominant cue for assigning sentence relations when other linguistic information was available.     

Using strategic psychotherapy: A case study of chronic PTSD after a terrorist attack

This article describes a case of chronic post traumatic stress disorder (PTSD). The patient came to psychotherapy three years after he was injured in a terrorist attack. He was in a state of dysfunction. The article elaborates on theoretical issues, the choice of strategic model of psychotherapy, the various phases of the therapeutic process and the specific difficulties that such a case presents.     

Forgiving the September 11th terrorists: associations with coping, psychological distress, and religiosity

Two studies examined how non-interpersonal forgiveness (when there is no social relationship between the transgressor and forgiver) related to coping and involuntary responses to stress, psychological distress, and religiosity. Three to six weeks after September 11th, 2001, forgiveness had non-linear associations with other responses to the terrorist attacks. Among college students (N=488), those who were trying or had forgiven (pro-forgiveness) the terrorists reported less involuntary engagement, more primary and secondary control coping, and more meaning finding than those who were unsure about forgiveness (ambivalent) and those who did not believe the perpetrators should be forgiven (anti-forgiveness). Ambivalent students reported the most distress, even after controlling for religion. Anti-forgiveness students reported less religiosity than ambivalent and pro-forgiveness students. Most findings were consistent among middle schoolers (N=154), particularly regarding psychological distress and responses to stress. Also, forgiveness of strangers for acts against one's community functioned separately from religion.     

How arousal modulates memory: Disentangling the effects of attention and retention

Emotion may influence memory both by altering attention and perception during encoding and by affecting memory retention. To date, studies have focused on the enhancement of memory consolidation by arousal. However, they have failed to rule out a role for attention. To specifically link memory enhancement of arousing material to modulation of memory retention, we examined recognition of neutral and arousing words at two time points and under conditions that manipulate attention during encoding. Participants were briefly presented with an arousing or neutral word at the periphery, while fixating on a central word. Recognition of peripheral words was assessed either immediately or after 24 h. Whereas recognition of neutral words became worse over time, recognition of arousing words remained the same and was better than neutral word recognition at delay. The results indicate that arousal supports slower forgetting even when the difference in attentional resources allocated to stimuli is minimized.     

Brain and behavioral inhibitory control of kindergartners facing negative emotions

Inhibitory control (IC) – one of the most critical functions underlying a child's ability to self‐regulate – develops significantly throughout the kindergarten years. Experiencing negative emotions imposes challenges on executive functioning and may specifically affect IC. In this study, we examined kindergartners' IC and its related brain activity during a negative emotional situation: 58 children (aged 5.5–6.5 years) performed an emotion‐induction Go/NoGo task. During this task, we recorded children's performance and brain activity, focusing on the fronto‐central N2 component in the event‐related potential (ERP) and the power of its underlying theta frequency. Compared to Go trials, inhibition of NoGo trials was associated with larger N2 amplitudes and theta power. The negative emotional experience resulted in better IC performance and, at the brain level, in larger theta power. Source localization of this effect showed that the brain activity related to IC during the negative emotional experience was principally generated in the posterior frontal regions. Furthermore, the band power measure was found to be a more sensitive index for children's inhibitory processes than N2 amplitudes. This is the first study to focus on kindergartners' IC while manipulating their emotional experience to induce negative emotions. Our findings suggest that a kindergartner's experience of negative emotion can result in improved IC and increases in associated aspects of brain activity. Our results also suggest the utility of time‐frequency analyses in the study of brain processes associated with response inhibition in young children.     

Functional imaging of working memory and peripheral endothelial function in middle-aged adults

The current study examined the relationship between a prognostic indicator of vascular health, flow-mediated dilation (FMD), and working memory-related brain activation in healthy middle-aged adults. Forty-two participants underwent functional magnetic resonance imaging while completing a 2-Back working memory task. Brachial artery endothelial-dependent flow-mediated dilation (FMD) was assessed using B-mode ultrasound. The relationship between FMD and task-related brain activation in a priori regions of interest was modeled using hierarchical linear regression. Brachial FMD, was significantly related to reduced working memory-related activation in the right superior parietal lobule (β = 0.338, p = 0.027), independent of age, sex, systolic blood pressure, and full scale IQ (F(5, 36) = 2.66, p = 0.038). These data provide preliminary support for the association between a preclinical marker of endothelial dysfunction and cerebral hemodynamic alterations in healthy middle-aged adults. Considering the modifiable nature of endothelial function, additional investigations on the prognostic significance of FMD on future cognitive impairment are warranted.