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931.
Katri Lahti Mervi Vänskä Samir R. Qouta Safwat Y. Diab Kaisa Perko Raija-Leena Punamäki 《Infant mental health journal》2019,40(2):186-203
We examined, first, how prenatal maternal mental health and war trauma predicted mothers’ experience of their infant crying, indicated by emotions, cognitions, and behavior; and second, how these experiences influenced the mother–infant interaction and infant development. Participants were 511 Palestinian mothers from the Gaza Strip, reporting their war trauma, symptoms of posttraumatic stress disorder (PTSD), depression, and perceived stress during pregnancy (Time 1). They reported experiences of infant crying at 4 months (Time 2), and the mother–infant interaction and infant sensorimotor and language development at 12 months of infants’ age (Time 3). Results revealed that maternal mental health problems, but not war trauma, were important to experiences of infant crying. A high level of PTSD symptoms predicted negative emotions evoked by infant crying, and high depressive symptoms predicted low active and positive responses to crying. Unexpectedly, high prenatal perceived stress predicted high active and positive responsiveness. Concerning the consequences, mothers’ sensitive interpretation of infant crying predicted optimal infant sensorimotor development, and mothers’ active and positive responses predicted high emotional availability in mother–infant interaction. Crying is the first communication tool for infants, and mothers’ sensitive responses to crying contribute to infant well-being. Therefore, reinforcing mother's optimal responses is important when helping war-affected dyads. 相似文献
932.
Perceived barriers to help-seeking among adolescents attending a suicide education program were examined. A total of 854 high school students in Colorado completed one of two questionnaires, measuring barriers to help-seeking for self or friend. The most prominent barriers for self were: inability to discuss problems with adults, self-overconfidence, fear of hospitalization, and lack of closeness to school adults. The most prominent barriers for troubled friends were: friendship concerns, unapproachability of school adults, fear of friend's hospitalization, and underestimating friend's problems. Results reveal multiple constraints limiting the program's utilization, supporting the need for comprehensive system approaches to suicide prevention. 相似文献
933.
Manin DY 《Cognitive Science》2008,32(7):1075-1098
Zipf's law states that if words of language are ranked in the order of decreasing frequency in texts, the frequency of a word is inversely proportional to its rank. It is very reliably observed in the data, but to date it escaped satisfactory theoretical explanation. This article suggests that Zipf's law may result from a hierarchical organization of word meanings over the semantic space, which in turn is generated by the evolution of word semantics dominated by expansion of meanings and competition of synonyms. A study of the frequency of partial synonyms in Russian provides experimental evidence for the hypothesis that word frequency is determined by semantics. 相似文献
934.
Doing unto future selves as you would do unto others: psychological distance and decision making 总被引:1,自引:0,他引:1
Four experiments showed that the decisions people make for future selves and other people are similar to each other and different from their decisions for present selves. Experiments involved decisions to drink a disgusting liquid for scientific purposes (Experiment 1), tutor peers during exam week (Experiment 2), receive e-mails for charity (Experiment 3), and defer a lottery prize for a larger one (Experiment 4). These findings seemed to be at least partially rooted in the tendency for decisions regarding the ongoing, present self to be uniquely influenced by internal subjective experience. Specifically, these effects emerged for real, but not hypothetical, decisions. Also, they were mitigated by manipulations that altered participants' attention to present or future subjective experience. In addition, when participants' subjective experience primarily involved empathy for others (Experiment 3), their decisions on behalf of present selves were more generous than their decisions for future selves and others. Applications are discussed. 相似文献
935.
Crystal X. Tan Rebecca P. Ang Robert M. Klassen Lay See Yeo Isabella Y. F. Wong Vivien S. Huan Wan Har Chong 《Current psychology (New Brunswick, N.J.)》2008,27(2):135-144
This study examined correlates of academic procrastination and students’ grade goals in a sample of 226 undergraduates from
Singapore. Findings indicated that self-efficacy for self-regulated learning was significantly and negatively related to procrastination.
High self-efficacy for self-regulated learning also predicted students’ expectations of doing well and low self-efficacy for
self-regulated learning predicted students’ expectations of not doing well academically. Additionally, help-seeking predicted
students’ expectations of doing well academically while academic stress predicted students’ expectations of not doing well
academically. Implications for education and educational practice were discussed.
This project was partially supported by the Undergraduate Research Experience on Campus (URECA) program from Nanyang Technological
University, Singapore. 相似文献
936.
Whether information perceived without awareness can affect overt performance, and whether such effects can cross sensory modalities, remains a matter of debate. Whereas influence of unconscious visual information on auditory perception has been documented, the reverse influence has not been reported. In addition, previous reports of unconscious cross-modal priming relied on procedures in which contamination of conscious processes could not be ruled out. We present the first report of unconscious cross-modal priming when the unaware prime is auditory and the test stimulus is visual. We used the process-dissociation procedure [Debner, J. A., & Jacoby, L. L. (1994). Unconscious perception: Attention, awareness and control. Journal of Experimental Psychology: Learning, Memory, and Cognition, 20, 304-317] which allowed us to assess the separate contributions of conscious and unconscious perception of a degraded prime (either seen or heard) to performance on a visual fragment-completion task. Unconscious cross-modal priming (auditory prime, visual fragment) was significant and of a magnitude similar to that of unconscious within-modality priming (visual prime, visual fragment). We conclude that cross-modal integration, at least between visual and auditory information, is more symmetrical than previously shown, and does not require conscious mediation. 相似文献
937.
Levy BR Ryall AL Pilver CE Sheridan PL Wei JY Hausdorff JM 《Anxiety, stress, and coping》2008,21(1):85-93
Although it has been shown that White elders are vulnerable to the influence of age stereotypes, it was not known whether this effect applied to African American elders. In the present study, African American elders were randomly assigned to negative or positive implicit-age-stereotype groups. Compared to participants in the positive age-stereotype group, those in the negative age-stereotype group demonstrated significantly more elevated cardiovascular response to stress, as measured by blood pressure and heart rate following mental challenges. These results suggest that negative age stereotypes generate a susceptibility to stress among African American elders, whereas positive age may provide them with a defense against this stress. 相似文献
938.
People tend to believe that sequences of random events produce fewer and shorter streaks than is actually the case. Although
this error has been demonstrated repeatedly and in many forms, nearly all studies of randomness cognition have focused on how people think about random events occurring in the present or future. This article examines how our biased
beliefs about randomness interact with properties of memory to influence our judgments about and memory for past random events.
We explore this interaction by examining how beliefs about randomness affect our memory for random events and how certain
properties of memory alter our tendency to categorize events as random. Across three experiments, we demonstrate an interaction
between randomness cognition and three well-established but distinct properties of memory: (1) the reconstructive nature of
memory, (2) primacy and recency effects, and (3) duration neglect. Theoretical and practical implications are discussed. 相似文献
939.
Corey B. Puryear Sheri J.Y. Mizumori 《Learning & memory (Cold Spring Harbor, N.Y.)》2008,15(12):895-898
As a key part of the brain’s reward system, midbrain dopamine neurons are thought to generate signals that reflect errors in the prediction of reward. However, recent evidence suggests that “upstream” brain areas may make important contributions to the generation of prediction error signals. To address this issue, we recorded neural activity in midbrain reticular formation (MRNm) while rats performed a spatial working memory task. A large proportion of these neurons displayed positive and negative reward prediction error-related activity that was strikingly similar to that observed in dopamine neurons. Therefore, MRNm may be a source of reward prediction error signals.The capacity of an organism to respond appropriately to environmental stimuli depends on the ability to detect changes in the outcome of its behavior. The mesocorticolimbic dopamine system is thought to be central to this function (Wise 2004; Fields et al. 2007). Dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) increase activity relative to the presentation of cues that predict rewards and rewards of greater value than expected, and decrease activity relative to rewards of less value than predicted (Nakahara et al. 2004; Bayer and Glimcher 2005; Pan et al. 2005; Tobler et al. 2005). This activity is thought to be involved in a computation about errors in the prediction of reward (Schultz and Dickinson 2000) that can be used to correct behavior. A central issue relevant to the behavioral and computational interpretation of dopamine signals is whether prediction error signals are generated by dopamine neurons, per se, or by cells in “upstream” brain areas.Recent data suggest that brain areas afferent to dopamine neurons generate, or participate in, reward prediction error computations. Lateral habenula, which has been shown to inhibit the activity of VTA and SNc dopamine neurons (Herkenham and Nauta 1979; Christoph et al. 1986), has recently been identified as a potential source of reward prediction error signals (Matsumoto and Hikosaka 2007). A similar finding has been demonstrated in the pedunculopontine tegmental nucleus (PPTg), which is an important regulator of dopamine neuron activity (Floresco et al. 2003). PPTg neural responses varied according to whether or not the animal received expected rewards (Kobayashi and Okada 2007).As part of a larger study investigating the role of VTA in context-dependent spatial working memory (C.B. Puryear, M.J. Kim, and S.J.Y. Mizumori, in prep.), we recorded the activity of neurons in the magnocellular region of the midbrain reticular formation (MRNm according to the method of Swanson [2003]) at the level of the diencephalon. The reticular formation is thought to be important for modulating arousal and vigilance levels necessary for attending to and acting upon salient stimuli (Pragay et al. 1978; Mesulam 1981), and it has recently been shown that this portion of the reticular formation provides glutamatergic input to VTA (Geisler et al. 2007). Thus, MRNm is in a prime position to modulate the activity of VTA dopamine neurons when the outcome of behavior does not meet expectations and therefore may be a source of reward prediction error signals. Accordingly, we investigated whether MRNm neurons exhibited reward related activity, and whether this activity was related to the ability to predict acquisition of reward.Four male Long-Evans rats (4–6 mo old from Simonson Laboratory, Gilroy, CA) were housed individually in Plexiglas cages in a temperature- and humidity-controlled environment (12:12 h light:dark). Rats were provided with food and water ad libitum for 5 d prior to being handled daily and reduced to 85% of ad libitum feeding weights. Animal care and use was conducted according to University of Washington’s Institutional Animal Care and Use Committee guidelines.Rats were habituated to the testing environment and trained to perform a differential reward, win-shift spatial working memory task using radial maze procedures reported previously (Pratt and Mizumori 2001; C.B. Puryear, M.J. Kim, and S.J.Y. Mizumori, in prep.). Briefly, prior to the start of each trial, the end of each of the eight maze arms was baited with either a large (five drops) or small (one drop) amount of chocolate milk on alternating arms. Maze arms containing large or small amounts of reward were counterbalanced across rats and held constant throughout training. Trials started with a sample phase by presenting four maze arms (two large and two small reward arms; individually and randomly selected) to the rat. Immediately after presentation of the fourth arm, a test phase began by making all maze arms accessible so the rat could collect the remaining rewards. The trial ended once all arms were visited. The rat was then confined to the center of the maze for a 2-min intertrial interval. Arm re-entries were counted as errors. Once the rat was able to perform at 15 trials in less than 1 h for seven consecutive days, recording electrodes were surgically implanted.Details concerning the construction of recording electrodes and microdrives and surgical procedures can be found in previous works (McNaughton et al. 1983; Puryear et al. 2006; C.B. Puryear, M.J. Kim, and S.J.Y. Mizumori, in prep.). Briefly, rats were chronically implanted with either eight stereotrodes (four/hemisphere) or four tetrodes (two/hemisphere) made from 25-μm lacquer-coated tungsten wire (California Fine Wire), centered on the following coordinates relative to bregma: −5.25 mm posterior, 0.7 mm lateral, 6 mm ventral. One week of free feeding was allowed for rats to recover from surgery before recording experiments began.Recordings were performed as described previously (Puryear et al. 2006; C.B. Puryear, M.J. Kim, and S.J.Y. Mizumori, in prep.). If no clear spontaneous neural activity was encountered, electrodes were lowered in ∼25-μm increments (up to 175 μm/d) until unambiguous, isolatable units were observed. Single units were isolated from multiunit records using standard cluster-cutting software (MClust; A.D. Redish, University of Wisconsin). A template-matching algorithm was also used to facilitate separation of unique spike waveforms. We only included cells that had a high signal-to-noise ratio (>3:1), exhibited stable clusters throughout the recording session, and had clear refractory periods in the interspike interval histograms following cluster cutting.The final position of each stereotrode was marked by passing a 25-μA current through each recording wire for 25 sec while rats were under 5% isofluorane anesthesia. Rats were then given an overdose of sodium pentobarbital and transcardially perfused (0.9% buffered saline, followed by 10% formalin). Electrodes were retracted, and the brain was removed and allowed to sink in 30% sucrose-formalin. Coronal sections (40 μm) were sliced with a cryostat and stained with cresyl violet. Recording locations were verified by comparing depth measurements and reconstructions of the electrode tracks. Only cells determined to be located in MRNm (Swanson 2003) were considered for analysis.Rats were well trained on the spatial working memory task, committing 0.86 ± 0.2 (mean ± SEM) errors per trial during the first five trials (baseline trials). Importantly, rats demonstrated the ability to discriminate large and small reward locations. There was a significant negative correlation between the first four test phase arm choices (i.e., first, second, third, and fourth arm choice) and the probability that the arm chosen contained a large reward (Fig. 1B; Spearman’s ρ = −0.65, P < 0.001), indicating that rats reliably visited large reward arms before small reward arms during the test phase of each trial.Open in a separate windowFigure 1.Histology and basic firing properties of MRNm neurons. (A) Distribution of cells localized to MRNm. Each dot may represent the location of more than one neuron. Coronal slices adapted from Swanson (2003) (reprinted with permission from Academic Press ©2003). (B) Rats displayed preference for arms that contained large amounts of reward. Plotted is the average probability of choosing a large reward arm during the first four arm choices of the test phase of each trial. Error bars represent SEM. (C) Distribution of average firing rates and spike duration of MRNm neurons. Most cells fired less than 10 spikes/sec and exhibited waveform durations between 1.5 and 2.0 msec. (D) Examples of two MRNm neurons. Top row shows their average waveform on each wire of the tetrode. Scale bar = 1 msec. Middle and bottom rows depict their interspike interval and autocorrelation histograms, respectively.A total of 18 cells localized to MRNm were recorded while rats performed the task. Of these, one cell was omitted from analysis due to a very low average firing rate (∼0.2 spikes/sec), yielding 17 cells included in the following analyses. Figure 1A depicts the distribution of cells localized to MRNm. These cells exhibited a range of average firing rates, spike durations (defined as the time from the start to the end of the action potential) (Fig. 1C), and firing patterns (for representative interspike interval and autocorrelation histograms, see Fig. 1D).Reward-related neural activity was obtained by placing rewards in small metal cups mounted to the end of each maze arm and connected to the recording equipment (custom designed by Neuralynx, Inc.), which served as “lick detectors.” An event marker was automatically inserted into the data stream when the rat licked the cup, providing an instantaneous measurement of the time the rat first obtained reward.In order to determine whether MRNm neurons exhibited significant reward-related activity, peri-event time histograms (PETHs) were constructed (50 msec bins, ±2.5 sec around each reward event). A cell was considered to have a significant excitatory reward response if it passed the following two criteria: (1) The cell had a peak firing rate within ±150 msec of reward acquisition and (2) the peak rate was >150% of its average firing rate for the block of trials. These criteria were applied to PETHs collapsed across reward amounts and separately for large and small reward events. Overall, 47% (eight of 17) of MRNm neurons were found to exhibit significant excitatory responses upon acquisition of reward (Fig. 2D). Of these cells, most (88%, seven of eight) were found to fire relative to acquisition of only large rewards (e.g., Fig. 2A–C), while the remaining neuron fired relative to acquisition of both reward amounts. No cells were found to fire preferentially to acquisition of only small rewards. Aspects of animals’ movement (e.g., velocity) were not found to be a major contributor to the firing patterns of MRNm neurons during performance of the spatial working memory task (data not shown). Therefore, it appears that MRNm unit activity is predominantly biased to represent higher reward values.Open in a separate windowFigure 2.Reward-related activity of MRNm neurons. (A) Peri-event time histograms of one cell that exhibited a short-latency, excitatory response upon acquisition of rewards (t(0), bin width = 50 msec). Left histogram shows only a modest excitatory response when considering all rewards together. However, top and bottom right histograms show that the reward-related firing occurred upon acquisition of large and not small rewards. Gray-shaded areas indicate time periods analyzed for significant increases in firing rate. (B) Population summary of the proportion of MRNm neurons that demonstrated significant reward-related activity.In order to determine whether MRNm reward-related activity was associated with reward prediction, we tested unit responses to unexpected alterations of reward outcome or elimination of visuospatial information important for reward prediction. To do this, we allowed the rat to perform a second block of five trials with either the locations of large and small rewards switched (reward location switch condition), with two rewards (one large and one small, randomly selected) omitted from the study phase of each trial (reward omission condition), or with the maze room lights extinguished (darkness condition). Importantly, each of these manipulations created situations in which reward prediction errors likely occurred. Overall, these three testing conditions created the following situations, respectively: a mismatch between the locations of large and small rewards, a decreased probability of obtaining a reward, and a situation in which rats are not able to discriminate between arms associated with large and small amounts of reward (C.B. Puryear, M.J. Kim, and S.J.Y. Mizumori, in prep.). Therefore, positive prediction errors could occur when the animal received a large amount of reward on an arm previously associated with a small amount, when the rat retrieved rewards after visiting arms in which reward had been omitted, and when the rat obtained a large reward in darkness. Negative reward prediction errors could occur when the animal received a small amount reward on a maze arm previously associated with a large amount, when the rat visited an arm that did not contain a reward, and when the rat obtained a small reward in darkness.Eight cells with significant responses to large rewards were recorded during these tests (two during reward location switch, four during reward omission conditions, and two during darkness conditions). In order to determine whether the reward manipulations affected the reward-related activity of these cells, a reward activity value (RA) was first calculated, which was the average firing rate in the ±150 msec around the time of acquisition of rewards, expressed as a percentage in change relative to the cell’s average firing rate for each block of trials. These values were normalized to the maximum RA value observed, yielding a normalized RA value for the first and second block of trials (RAn1 and RAn2, respectively). These calculations were made for large and small rewards separately, and for non-rewarded arms in the reward omission condition.We then created scatterplots of RAn’s for each block of trials. If reward-related activity was independent of the expectation of the reward received, RAn1 and RAn2 should be similar in each block of trials. As can been seen in Figure 3A, the reward-related activity was consistently higher when rats received more reward than expected in the second block of trials. Conversely, Figure 3B clearly shows that neural activity was consistently suppressed when rats received less reward than expected. These differences in reward-related firing were quantified by calculating the distance of each data point to the diagonal (i.e., the reward activity change index, or RACI):
Directionality of the change in reward activity was taken into account in order to discern between increases and decreases in firing rate. A one-sample t-test (α = 0.05) indicated that average RACI values were significantly increased when rats received more reward than expected (t(7) = −2.73, P < 0.03) and were significantly decreased when rats received less reward than expected (t(7) = −4.88, P < 0.001). These results are consistent with positive and negative reward prediction error signals, respectively. An example of an MRNm neuron that exhibited both positive and negative prediction error-related activity in the reward location switch condition is depicted in Figure 3D.Open in a separate windowFigure 3.Reward prediction errors in MRNm neurons. (A) Plotted is each neuron’s normalized large reward activity (RAN, defined in text) for each block of trials. The reward activity during block 2 (y-axis) represents activity at times when more reward than expected was obtained. Note that reward-related activity during these times is consistently more robust than during times in which the rat received the expected reward (block 1), indicating that positive reward prediction errors occurred. (B) Plotted are RAN values for rewarded and devalued arms in block 2 (x- and y-axes, respectively). Devalued arms include arms associated with a large amount of reward but baited with a small amount of reward, arms in which reward was omitted, and arms containing small rewards visited in darkness. Note that reward-related activity on devalued arms is consistently suppressed, indicating that negative reward prediction errors occurred. (Symbols in A,B: ● indicates cell recorded in darkness condition; o, cell recorded in reward omission condition; and x, cell recorded in reward location switch condition.) (C) Average changes in reward activity (RACI, defined in text) for times in which the rat obtained more and less reward than expected. Asterisks indicate significant differences (P < 0.05). Error bars indicate SEM. (D) An example of one neuron that did not respond to acquisition of rewards during the first block of trials. When the locations of large and small rewards were switched, however, the cell developed an excitatory response to acquisition of large rewards on arms previously associated with small amounts of reward (positive reward prediction error). Furthermore, the firing of the cell was inhibited upon acquisition of small rewards on arms previously associated with large amounts of reward (negative reward prediction error).We demonstrate here that a large proportion of MRNm neurons may be involved in computations about reward acquisition. Similar to dopamine neurons (Tobler et al. 2005), the majority of reward-related MRNm neurons preferentially fired relative to acquisition of large amounts of reward. To our knowledge, this is the first demonstration of discriminative reward responses of reticular formation neurons and highlights a novel role for the reticular formation in reward value representations. Furthermore, these data suggest that MRNm neurons represent similar reward prediction error signals as dopamine neurons (Nakahara et al. 2004; Bayer and Glimcher 2005; Pan et al. 2005; Tobler et al. 2005). It is important to note that in this initial sample, there was remarkable overall consistency and reliability of the positive and negative reward prediction error signals by MRNm neurons. This is similar to the homogeneity of dopamine neuron responses, suggesting that reward prediction may be a major function of the overall population of MRNm reward-related neurons. Nevertheless, further parametric studies are necessary to determine whether MRNm neural activity conforms to the same basic firing profiles that have been well-described for dopamine neurons (i.e., predictive cues and reward probabilities).The reticular formation has traditionally been thought to be important for initiating general arousal states. This is in part due to initial reports of changes in unit activity during transitions from sleep to wakefulness (Huttenlocher 1961; Kasamatsu 1970; Manohar et al. 1972). In addition, a more specific role for the reticular formation in attention has been described in primates performing visual discrimination tasks (Pragay et al. 1978; Fabre et al. 1983). This is consistent with reports of sensory neglect following reticular formation lesions (Watson et al. 1974). Together, these foundational data suggest that reticular formation may function to enhance the overall level of arousal and vigilance necessary for attending to and acting upon salient stimuli (Mesulam 1981). Accordingly, changes in reward-related MRNm neuronal activity could provide an important signal indicating that the contingencies of recently executed behaviors have changed.The striking similarity of the reward prediction error signals of MRNm neurons reported here suggests that MRNm, along with brain regions such as lateral habenula (Matsumoto and Hikosaka 2007), pedunculopontine nucleus (PPTg) (Kobayashi and Okada 2007), and dorsal raphé nucleus (Nakamura et al. 2008) may contribute to the generation of reward prediction error signals observed in dopamine neurons. Furthermore, these data suggest the possibility that such signals are a general property of a large network of midbrain structures. Given that the projections from the reticular formation to VTA are glutamatergic (Geisler et al. 2007), it is possible that the changes in reward-related activity of MRNm neurons, in concert with PPTg, could provide an excitatory component of the reward prediction error signal. In combination with inhibitory inputs from lateral habenula, this may then selectively activate dopamine neurons to initiate the coordinated selection of appropriate behaviors in response to changes in reward outcome (Humphries et al. 2007). 相似文献
940.
Abrari K Rashidy-Pour A Semnanian S Fathollahi Y 《Neurobiology of learning and memory》2008,89(2):178-184
Reactivation of stabilized memories returns them to a labile state and causes them to undergo extinction or reconsolidation processes. Although it is well established that administration of glucocorticoids after training enhance consolidation of contextual fear memories, but their effects on post-retrieval processes are not known. In this study, we first asked whether administration of corticosterone after memory reactivation would modulate subsequent expression of memory in rats. Additionally, we examined whether this modulatory action would depend upon the strength of the memory. We also tested the effect of propranolol after memory reactivation. Adult male Wistar rats were trained in a fear conditioning system using moderate (0.4 mA) or high shock (1.5 mA) intensities. For reactivation, rats were returned to the chamber for 90 s 24h later. Immediately after reactivation, rats were injected with corticosterone (1, 3 or 10mg/kg) or vehicle. One, 7 and 14 days after memory reactivation, rats were returned to the context for 5 min, and freezing behavior was scored. The findings indicated that corticosterone when injected after memory reactivation had no significant effect on recall of a moderate memory, but it impaired recall of a strong memory at a dose of 3mg/kg. Propranolol (5mg/kg) given after the reactivation treatment produced a modest impairment that persisted over three test sessions. Further, the results showed that corticosterone, but not propranolol deficit was reversed by a reminder shock. These findings provide evidence that administration of glucocorticoids following memory reactivation reduces subsequent retrieval of strong, but not moderate, contextual conditioned fear memory likely via acceleration of memory extinction. On the other hand, propranolol-induced amnesia may result from blockade of reconsolidation process. Further studies are needed to determine the underlying mechanisms. 相似文献