Action‐semantic and syntactic deficits in subjects at risk for Huntington's disease

Frontostriatal networks play critical roles in grounding action semantics and syntactic skills. Indeed, their atrophy distinctively disrupts both domains, as observed in patients with Huntington's disease (HD) and Parkinson's disease, even during early disease stages. However, frontostriatal degeneration in these conditions may begin up to 15 years before the onset of clinical symptoms, opening avenues for pre‐clinical detection via sensitive tasks. Such a mission is particularly critical in HD, given that patients’ children have 50% chances of inheriting the disease. Against this background, we assessed whether deficits in the above‐mentioned domains emerge in subjects at risk to develop HD. We administered tasks tapping action semantics, object semantics, and two forms of syntactic processing to 18 patients with HD, 19 asymptomatic first‐degree relatives, and sociodemographically matched controls for each group. The patients evinced significant deficits in all tasks, but only those in the two target domains were independent of overall cognitive state. More crucially, relative to controls, the asymptomatic relatives were selectively impaired in action semantics and in the more complex syntactic task, with both patterns emerging irrespective of the subjects’ overall cognitive state. Our findings highlight the relevance of these dysfunctions as potential prodromal biomarkers of HD. Moreover, they offer theoretical insights into the differential contributions of frontostriatal hubs to both domains while paving the way for innovations in diagnostic procedures.     

Personality Disorders Are Not as We Thought: Hierarchical Factor Structure at the Criterion Level

The use of personality disorder (PD) categories persists, despite the evidence against them. An often overlooked reason for this is the fact that the true structure underlying the Diagnostic and Statistical Manual of Mental Disorders (DSM) taxonomy is still unknown: We cannot be certain which disorders are valid, and which ones are arbitrary mixtures of heterogeneous traits. To address this gap, we factor analyzed the Personality Diagnostic Questionnaire (PDQ–4+; Hyler, 1994 Hyler, S. E. (1994). PDQ–4+ Personality Diagnostic Questionnaire–4+. New York, NY: New York State Psychiatric Institute. [Google Scholar]) at the criterion level in a mixed clinical and nonclinical sample of 2,519 individuals. The resulting structure was more similar to current dimensional taxonomies than to the DSM classification at all hierarchical levels. Whereas paranoid and antisocial PDs—and to a lesser extent avoidant, dependent, depressive, and schizoid PDs—were fairly homogeneous, all other disorders turned out to be combinations of 2 or 3 unrelated dimensions. Our results strongly support the structure of empirically based dimensional taxonomies and relocate DSM criteria within this emerging framework, thus contributing to preserving much of the knowledge accumulated to date.     

Interwoven stories: our path of creativity and poetry named the ecodialogue center

The history of organizations and collectives is something alive. It is a network of memories, actions, collaborations, dreams, encounters, and disconnections that live within each of its members. The EcoDialogue Center is an academic space of the University of Veracruz for promoting dialogue between disciplines. In this article we are presenting the stories, both personal and collective, and the values and ideals that create our Center. We are using this opportunity to reflect on the cultural, geographical, emotional, intellectual, and societal conditions that have allowed this innovative process within the rules and customs of a university.     

Reading the Lives of Others: Biography as Political Thought in Hannah Arendt and Simone de Beauvoir

In this essay, I focus on two biographical works by Hannah Arendt and Simone de Beauvoir that I read as political texts: Rahel Varnhagen: The Life of a Jewess (Arendt 1957 ) and “Must We Burn Sade?” (Beauvoir 2012 ). Reading Arendt's Varnhagen and Beauvoir's “Sade” side by side illuminates their shared preoccupation with lived experience and their common political premises: the antagonism between freedom and sovereignty, and the centrality of action and constructive relations with others. My argument is that these texts constitute an original style of political thinking, which I call politico‐biographical hermeneutics, or reading the life of others as exercises in political theory. Politico‐biographical hermeneutics, as I take it, is not a systematic methodology, but an approach to interpreting sociopolitical forces as they come to bear and are embodied and inscribed in the lived experiences, struggles, and works of representative or exemplary individuals. This approach identifies the political lessons of lived experience and supports one of the central claims of feminist philosophy, namely, that the personal and the political are not antithetical, but relational.     

Motivated attention to fear-related stimuli: Evidence for the enhanced processing of fear in the late positive potential

Differences in the processing of emotions like fear and sadness have important implications for our understanding of many psychological phenomena (e.g., attentional biases, psychopathology). The late positive potential (LPP) is an established event-related potential that reflects motivated attention to emotional stimuli at the neural level with excellent temporal resolution, but has been infrequently used to study differences across emotions. Drawing on functional theories of emotion suggesting that the quick processing of fear-inducing stimuli increases chances of survival, we hypothesized that fear-inducing pictures would produce larger LPP amplitudes compared to other emotions (happy and sad) in the early time windows of the LPP (e.g., 400–700, 700–1000 ms). The results supported our hypothesis, offering new, albeit preliminary, evidence of the differential processing of threat-related stimuli on the LPP.     

Rules and Games

Philosophia - We have taken a look at the rules of games in order to acquire some knowledge concerning constitutive rules and, probably, institutional phenomena in general. In this paper we tried...