Infant hypotonia, obesity, hypogenitalism and oligophrenia--new viewpoints on the etiology and symptoms of Prader-Willi syndrome

We present four cases of Prader-Willi syndrome. Two of them have an abnormality of a chromosome 15, the other both show different chromosomal abnormalities. Translocations or deletions were found recently in the bands 15q11/12 in about 60% of the cases of Prader-Willi syndrome. The consequences for diagnosis, symptomatology and genetic counselling of the syndrome are discussed.     

Selective association in conditioned stress-induced analgesia: functional differences in interoceptive and exteroceptive sensory pathways

Rats were used to determine whether stress-induced analgesia (SIA) can be produced by conditioning with interoceptive stimuli (LiCl) as with exteroceptive stimuli (footshock). SIA was measured using a tail-flick test. As expected, unavoidable footshock as well as conditioning with footshock produced SIA. In contrast, conditioning with LiCl failed to cause SIA. The findings support the notion of functional differences in neural substrates for conditioning by exteroceptive and interoceptive cue.     

Changes in self-stimulatory behaviors with treatment

For four of six autistic children who underwent intensive behavioral treatment, the nature of their self-stimulatory behavior changed from initial lowlevel motor behaviors (such as rocking, spinning, twirling) to differing kinds of higher-level behaviors (such as lining of objects, echolalic speech, and preoccupation with spelling and numerical values). The children who changed to the highest levels of self-stimulatory behavior also showed the largest gains in treatment (as determined by IQ scores, school placement, etc.). The changes in self-stimulatory behaviors were attributed to the intense teaching of appropriate social behaviors and the explicit therapeutic suppression of low-level, self-stimulatory behaviors. The long-term therapeutic effects of changing from lower-to higher-level forms of self-stimulatory behavior were discussed.This study was supported by a grant from the National Institute of Mental Health (grant MH 11440). We want to express our thanks to the parents who allowed us to study their children. We gratefully acknowledge the assistance of Maria Audero with the design of the weighted measure, and Tracee Parker with the collection of the data.     

The word-superiority effect under conditions that approximate reading

Observers detected a briefly flashed target letter embedded in word, pronounceable nonword, and unpronounceable nonword contexts. The word context facilitated perception under both holistic and analytical processing strategies; the facilitative effect was enhanced when processing was analytical.     

Contrast requirements for picture recognition: converging evidence for a spatial frequency hypothesis

Based upon perceptual studies, the present hypothesis was that different ranges of spatial-frequency information constitute different sources of information for recognition memory. In Experiment 1, 40 subjects were tested with sets of focused and unfocused pictures as inspection and test stimuli. In addition to reporting whether each test picture was believed to be a member of the inspection set or a novel picture, each subject was allowed to adjust the contrast of the stimulus until such a judgment could be made. In Experiment 2, subjects made similar judgments when inspection or test stimuli were flickered (perceptually enhancing low spatial frequencies) or unflickered. Results from both studies were consistent with the experimental hypothesis. Other studies were reviewed, which, together with the present data, lend converging evidence to the spatial-frequency hypothesis.     

Adolescent marijuana use: the role of the physician

Adolescent marijuana use is an issue of concern to the community at large. Physicians now have the technology to identify marijuana use and thus are in a unique position to deal with the issue. This article addresses the moral issues related to screening and surveillance of adolescent marijuana use and postulates the justification for active physician intervention.