Functional and pharmacological characterization of the first specific agonist and antagonist for the V1b receptor in mammals

By activating three distinct vasopressin receptor isoforms called V1a-R, V1b-R (V3-R) and V2-R, vasopressin (VP) mediates a wide number of biological effects in mammals and may be involved in several pathological states. Up to now only specific V1a and V2 receptor agonists and antagonists have been successfully designed. The role of the V1b-R still remains partially unknown, due to the lack of selective V1b-R ligands and orally-active molecules, which are crucial tools for investigating the central and peripheral functions or pathological disorders associated with this receptor. In this review, we report the biological and pharmacological properties of the first two specific V1b-R ligands: d[Cha4] AVP, a high affinity V1b-R agonist and SSR149415, a potent orally-active V1b-R antagonist with good selectivity with respect to other VP/OT receptor isoforms and able to control ACTH secretion in vitro and in vivo. Indeed, these molecules constitute invaluable tools for exploring the central and peripheral roles of VP mediated via V1b receptors. Interestingly, SSR149415 displays potent anxiolytic and antidepressant-like activities, indicating that this new class of drugs has a promising therapeutical potential in the treatment of stress-related disorders, anxiety and depression.     

Science,Technology and Ethics: From Critical Perspective to Dialectical Perspective

It has been agreed upon, according to critical perspective, to distinguish the problems raised by scientific issues on the one hand and the problems raised by moral issues on the other. This distinction, at the genesis of theoretical ideology, postulates that experimental science is mere knowledge which, since it has nothing to do with action, cannot raise a moral problem. Yet the use of experimental techniques turns out to be a necessary means, although an insufficient one, to put to the test and to confirm the theoretical hypothesis of science. Thus, those techniques produce perceptible effects which can be assimilated to genuine transformation and are consequently capable of raising moral problems. It follows that the technical imperative of science can be conditioned by a moral imperative of technique, which leads to modification of the object of the research and dubs it, a dialectical object. It is, however, advisable to effect a demarcation between that which, within the frame work of research in experimental science, can pose a moral problem and which cannot. The criterion of refusability of practical projects, by analogy with Popper’s criterion of refutability of theoretical conjectures, allows for this demarcation to be implemented. It postulates that only the technical projects of science, apart from scientific theories, can pose a moral problem or can be recognized as moral, providing that the conditions of a possible ethical refusal can be expressed. From the analysis and the synthesis of heterogeneous possibilities, dialectical perspective thus outlined represents an endeavour to go beyond critical perspective, while trying to seek an intermediary channel between the “progressist dogmatism” of science and the “obscurantist scepticism” of morals.     

Clarivate Analytics: Continued <Emphasis Type="Italic">Omnia vanitas</Emphasis> Impact Factor Culture

This opinion paper takes aim at an error made recently by Clarivate Analytics in which it sent out an email that congratulated academics for becoming exclusive members of academia’s most cited elite, the Highly Cited Researchers (HCRs). However, that email was sent out to an undisclosed number of non-HCRs, who were offered an apology shortly after, through a bulk mail, which tried to down-play the importance of the error, all the while praising the true HCRs. When Clarivate Analytics senior management was contacted, the company declined to offer an indication of the number of academics who had been contacted and erroneously awarded the HCR status. We believe that this regrettable blunder, together with the opacity offered by the company, fortify the corporate attitude about the value of the journal impact factor (JIF), and what it represents, namely a marketing tool that is falsely used to equate citations with quality, worth, or influence. The continued commercialization of metrics such as the JIF is at the heart of their use to assess the “quality” of a researcher, their work, or a journal, and contributes to a great extent to driving scientific activities towards a futile endeavor.     

Sports and ‘Minorities’: Negotiating the Olympic Model

This paper studies ‘minority’ initiatives to organize sports games. A meta-analysis of published data in the literature identifies the formal appearance taken by each of these initiatives under the Olympic model. But it also conduces to build a number of indicators to answer a series of questions about their logic and strategies. All the initiatives studied are based on an ambivalent posture that, while based on the denunciation of a discriminating space, claim access to it. By an astonishing paradox, ‘non-normative’ actors are driven to reclaim a model that, under cover of Universal, aims to establish a norm that is situated and dated. In practice, they use two types of strategies: a strategy for participation in the Olympics to transform them into a space which represents a fight against exclusion, or a strategy to create alternative events. Whatever the strategy, these initiatives are implemented according to their objectives. Differentiated in their forms—participatory or autonomy—they are also in their purpose. The comparison of these initiatives shows that ultimately, beyond strategies and logic inherent in different social, historical and organizational contexts, the mobilizations of the actors reveal the same ambivalence about the sports model conveyed by the Olympic institution.     

Variations in internet-related problems and psychosocial functioning in online sexual activities: implications for social and sexual development of young adults.

This survey of 760 university students examined differences in Internet-related problems and psychosocial functioning between four patterns of participation in online sexual information and entertainment activities. Students who did not participate in either online sexual activity were more satisfied with their offline life and more connected to friends and family. Those who engaged in both online sexual activities were more dependent on the Internet and reported lower offline functioning. Students who only sought sexual information maintained strong offline affiliations. Those who only sought entertainment did not report lower offline functioning. Respondents most deficient in offline social support did not report compensatory online support. Despite students' common participation in online sexual activities (OSA) as a venue for social and sexual development, those relying on the Internet and the affiliations it provides appear at risk of decreased social integration. The authors discussed the finding's implications for social and sexual development.     

Sport participation,screen time,and personality trait development during childhood

This investigation explored the contribution of extracurricular sport and screen time viewing (television viewing and electronic gaming) to personality trait stability and change during childhood. Two independent samples of 3,956 young children (age 6) and 3,862 older children (age 10) were taken from the Longitudinal Study of Australian Children. Parent‐reported child sport participation, screen time, and personality traits were measured at baseline and again 24 months later. Young children who were more active recorded more of a decrease in introversion, less of a decrease in persistence, and less of an increase in reactivity, than those who were less active. Older children who were more active recorded less of an increase in introversion and more of an increase in persistence than those who were less active. In addition, young children who continued participation in extracurricular sport had greater intra‐individual stability of personality for introversion. These finding suggest that an active lifestyle might help to facilitate desirable personality trait stability and change during childhood.