Risk and Trust in Public Health: A Cautionary Tale

The leading ethical position on placebo-controlled clinical trials is that whenever proven effective treatment exists for a given condition, it is unethical to test a new treatment for that condition against placebo. Invoking the principle of clinical equipoise, opponents of placebo-controlled trials in the face of proven effective treatment argue that they (1) violate the therapeutic obligation of physicians to offer optimal medical care and (2) lack both scientific and clinical merit. We contend that both of these arguments are mistaken. Clinical equipoise provides erroneous ethical guidance in the case of placebo-controlled trials, because it ignores the ethically relevant distinction between clinical trials and treatment in the context of clinical medicine and the methodological limitations of active-controlled trials. Placebo controls are ethically justifiable when they are supported by sound methodological considerations and their use does not expose research participants to excessive risks of harm.     

Cognitive and emotional characteristics of New Religious Movement members: New questions and data on the mental health issue

The common assumption that members of so-called “cults” and New Religious Movements (NRMs) have mental health problems is usually countered by empirical research suggesting a normal personality profile. Going further than the normality–pathology distinction, we investigated affective-relational (parental and adult attachment) and cognitive (need for closure) needs, world assumptions, and past and present depression as reported by members (N?=?113) of a variety of NRMs in Belgium that are somewhat socially contested. Comparisons were made with data from the general population. Results suggest a fragile past (insecure attachment history, high need for closure, and depressive tendencies) but a positive present (positive world assumptions, security in adult attachment, no depression) and an optimistic future, at least on the basis of self-perceptions. Overall, the pattern of results fit well with what we know from psychology of conversion in general.     

Jan Patočka’s sacrifice: philosophy as dissent

This article attempts to bring together the life, situation, and philosophical work of the Czech phenomenologist Jan Pato?ka in order to present his conception of philosophy and sacrifice and to understand his action of dissent and his own sacrifice as spokesman for Charter 77 in light of these concepts. Pato?ka philosophized despite being barred from teaching under the German occupation and under the communist regime, even after he was forced to retire and banned from publication. He also refused the official philosophical categories of communism and, what is more, criticized the very manner in which its ideology allowed it to function. Against the destruction of moral and political life by communist and liberal regimes alike, he outlined the necessity of a “life in the idea” that would be responsive to the notion of sacrifice. Such a position of distance from the things of the world which remains anchored among them is meant to respond to dissatisfaction with the world as it is found and is the very movement of human freedom. Taken together, these three aspects of his philosophical practice made him a dissident, a role he took on more completely when, as part of the Charter 77 movement, he publicly opposed the state, in a course of action that led to his death.     

浅析肿瘤疫苗

肿瘤疫苗作为肿瘤特异性主动免疫治疗的方式,目的是激发启动,调节增强机体固有的免疫功能和抗癌能力以维护机体生理平衡。具有使机体由被动抗癌向主动抗癌转变的特点。     

“人体器官移植工作体系”框架的初步构想及其伦理使命

借鉴国内外相关成功经验,结合我国实际情况,对“人体器官移植工作体系”的构成以及各系统职能进行初步探讨。研究了该体系在阻止人体器官商业化、提高人体移植器官分配的公平高效性等方面发挥的作用。     

卫生服务公平性:理念、制度和实践——读《关于深化医药卫生体制改革的意见(征求意见稿)》有感

长期以来,我国的卫生服务一直存在着不公平的状况,看病难、看病贵等问题在农村表现十分突出,一直是社会关注的焦点。对卫生服务不公平问题的讨论也已经持续很久,正因为如此,人们对新一轮的卫生体制改革寄予厚望。人们深知,实现卫生服务公平性需要从理念转变到人、财、物的支持,从构建相应的制度、机制、法规到付诸实践等多方面着手,只有这样才能实现人人享有卫生保健的目标。     

大鼠作业成绩与脑内亮氨酸脑啡肽含量变化的相关性研究

本工作采用穿梭式电击回避反应法和脑啡肽的放射免疫测定法,分析比较了大鼠作业成绩与脑内壳氨酸脑啡肽(Leu-enkephalin,LEK)含量的关系,在本实验条件下,观察到作业成绩不良组纹状体内LEK含量显著高于成绩优良组和对照组,并由实验证明,它们之间的差异不是由于在实验中接受电击的次数或电击总量不同造成的。这一结果提示,内源性亮氨酸脑啡肽可能参与记忆获得的调制。     

肝移植的伦理学问题

肝脏移植和其它器官移植一起实现了人类长期以来渴望生命再生的梦想,并成为终末期肝病的有效治疗方法。器官移植也面对许多伦理道德方面的难题。供体,特别是活体器官的摘取,受体的选择等,都受到社会道德观的制约。从伦理道德角度来分析如何制定相关的法律法规,成为当前社会关注的热点。从受体的利益、人体科研的道德规范以及相关制度的伦理学要求等方面,较为详细的阐述肝移植伦理学的基本原则。