Neuropsychological outcome of GPi pallidotomy and GPi or STN deep brain stimulation in Parkinson's disease

This paper highlights the neuropsychological sequelae of posteroventral pallidotomy (PVP) and deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the internal segment of the globus pallidus (GPi) at 3/6 months postoperatively. Results are based on our extensive experience with PVP and our preliminary observations with DBS. Patients with borderline cognitive or psychiatric functioning risk postoperative decompensation. Nonlateralizing attentional and hemisphere-specific impairments of frontostriatal cognitive functions followed unilateral PVP. "Frontal" behavioral dyscontrol was observed in approximately 25% of patients. Three cases of staged bilateral PVP suggest that premorbid factors may predict outcome, although lesion size and location are also critical. Older patients are at risk for significant cognitive and behavioral decline after bilateral STN DBS, while GPi DBS may be safer.     

Nutritional Contributions to the CNS Pathophysiology of HIV-1 Infection and Implications for Treatment

Nutritional deficiencies are commonplace in patients with human immunodeficiency virus type 1 (HIV-1) infection, and recent research has indicated that nutritional factors may play an important role in the pathogenesis of HIV-1 disease. Although nutritional deficiencies are unlikely to be the primary causative factor in disease progression, they may contribute to cognitive dysfunction, neurologic abnormalities, mood disturbance, and immune dysregulation associated with HIV-1 infection. Furthermore, deficiencies of specific micronutrients have been associated with increased risk of HIV-1-associated mortality. This article will briefly summarize the role of macronutrient deficiency, the interactions of specific micronutrient deficiencies with neuropsychiatric functioning, and the role of these factors in HIV-1 disease progression. Since recent research has shown that normalization of many nutritional deficits and supplementation beyond normal levels are associated with improvements in neuropsychiatric functioning, potential treatment implications will also be discussed.     

Neural dichotomy of word concreteness: a view from functional neuroimaging

Our perception about the representation and processing of concrete and abstract concepts is based on the fact that concrete words are highly imagined and remembered faster than abstract words. In order to explain the processing differences between abstract and concrete concepts, various theories have been proposed, yet there is no unanimous consensus about its neural implication. The present study investigated the processing of concrete and abstract words during an orthography judgment task (implicit semantic processing) using functional magnetic resonance imaging to validate the involvement of the neural regions. Relative to non-words, both abstract and concrete words show activation in the regions of bilateral hemisphere previously associated with semantic processing. The common areas (conjunction analyses) observed for abstract and concrete words are bilateral inferior frontal gyrus (BA 44/45), left superior parietal (BA 7), left fusiform gyrus and bilateral middle occipital. The additional areas for abstract words were noticed in bilateral superior temporal and bilateral middle temporal region, whereas no distinct region was noticed for concrete words. This suggests that words with abstract concepts recruit additional language regions in the brain.     

Fostering Employee Creativity through Transformational Leadership: Moderating Role of Creative Self-Efficacy

This study examined the moderating role of creative self-efficacy in predictions of employees’ creativity through transformational leadership. Data from a dyadic sample of 424 employees and their immediate supervisors were collected and analyzed. The results signify that transformational leaders promote creativity among their subordinates. Further, a significant moderating role of creative self-efficacy was found in the relationship between transformational leadership and employee creativity. The findings reveal that employees working under transformational leaders more likely to resort creative behavior when they perceive high creative-self-efficacy.     

Synthesis of nanostructured vanadium powder by high-energy ball milling: X-ray diffraction and high-resolution electron microscopy characterization

Vanadium metal powders, ball milled with different surfactants viz., stearic acid, KCl and NaCl, have been studied by X-ray diffraction and transmission electron microscopy. The surfactants alter the microstructural and morphological characteristics of the powders. Ball milling with stearic acid results in solid-state amorphization, while powders milled with KCl yield vanadium–tungsten carbide nanocomposite mixtures. NaCl proved to be an excellent surfactant for obtaining nanostructured fusion-grade vanadium powders. In order to understand the reaction mechanism behind any interstitial addition in the ball-milled powders, CHNOS analysis was performed.     

Effects of fear on exploratory behaviour in rats

It has been suggested that mild fear may evoke rather than inhibit exploratory responses in rats. The relationship between conditioned fear and exploratory behaviour was analysed in three experiments and there was no evidence that mild fear increased exploration. Conditioned fear was found to be under relatively precise stimulus control and its magnitude was related to the intensities and durations of the unconditioned stimulus, inescapable electric shock.     

How teachers use the group I.Q. test scores

Ninety elementary school teachers, grades 2–6, in two school districts in Ohio were interviewed to obtain information on how they used the results of group IQ tests. Twenty-seven of 90 teachers (30%) reported making “little or no use” of the test scores. Most of these teachers presumably had more faith in their own tools and observations than in the IQ test scores. However, 76 of 90 teachers (84%, including the ones who made little use of the test scores) stated that they used the test scores for one or more purposes. The four most frequently mentioned uses were: (a) “for discussion in parent conferences” (51%); (b) “to know a student's potential and/or determine ability-motivation discrepancy” (42%); (c) “to plan instruction” (39.5%) and (d) “for referral purposes” (29%). The instructional strategies mentioned by the teachers varied and were categorized into 21 categories.     

Extent of Hostility in Educated Indian Unemployed Youth: A Micro Analysis

This study was designed to ascertain the level of hostility in educated unemployed youth (N = 150) as against employed youth (N = 150) at micro level by employing an Indian adaptation of the Buss-Durkee Hostility Scale. Results of statistical comparison revealed a significant difference between the two groups in terms of hostility and its various dimensions barring indirect aggression, negativism, and verbal aggression. However, both the groups tended to have a moderate amount of hostility and its dimensions. The results further showed the relative standing of the two groups on the dimensions of hostility, positing the job-seekers as possessing a high sense of guilt and low indirect aggression, and the employed youth, being high on irritability, and, like their counterparts, low on indirect aggression. Also, the study indicated a correlation among the dimensions of hostility with one another and with the total scale scores.