Cognitive processes that underlie mathematical precociousness in young children

The working memory (WM) processes that underlie young children's (ages 6-8 years) mathematical precociousness were examined. A battery of tests that assessed components of WM (phonological loop, visual-spatial sketch pad, and central executive), naming speed, random generation, and fluency was administered to mathematically precocious and average-achieving children. The results showed that (a) precocious children performed better on executive processing, inhibition, and naming speed tasks than did average-achieving children, although the two groups were statistically comparable on measures of the phonological loop and visual-spatial sketch pad, and (b) the executive component of WM predicted mathematical accuracy independent of chronological age, reading, inhibition, and naming speed. The results support the notion that the executive system is an important predictor of children's mathematical precociousness and that this system can operate independent of individual differences in the phonological loop, inhibition, and reading in predicting mathematical accuracy.     

The use of a laboratory school protocol to evaluate concepts about efficacy and side effects of new formulations of stimulant medications

Recently, new long-acting formulations of racemic methylphenidate (MPH: Ritalin LA, Metadate CD and Concerta) and amphetamine (AMP: Adderall XR) were developed and are now approved by the Food and Drug Administration (FDA). In addition, dexmethylphenidate (Focalin), the pharmacologically active d-threo enantiomer of MPH, also was approved by the FDA. In the initial phases of development, prototypes of these five new formulations were evaluated using the University of California, Irvine (UCI) Laboratory School Protocol (LSP), in which surrogate measures of efficacy are collected in highly controlled settings rather than clinical measures of effectiveness in the less-controlled, natural environments of home or school. The LSP studies were followed by large effectiveness and safety studies required for gaining FDA approval. These initial efficacy and side effect studies in the LSP provided missing information about the basic pharmacokinetic (PK) and pharmacodynamic (PD) properties of MPH and AMP and produced some new discoveries (i.e., acute tolerance) that were used to help design the final products. The final once-a-day formulations used different drug delivery systems to achieve long-acting efficacy (Ritalin LA, Metadate CD, Concerta, Adderall XR). All four drug delivery systems were based on two processes: first, a bolus delivery (BD) process to achieve rapid onset of efficacy (mg), and second, a controlled delivery (CD) process to achieve rates of delivery (mg/hr) or a delayed bolus (mg) to maintain efficacy. A theoretical approach was used to compare and contrast the new once-a day formulations of MPH by selecting total daily doses (mg/d) that would equate drug delivery by the first process (mg of the initial bolus) and the second process (mg/hr over specified time period). In addition to efficacy, applications of the LSP to measure common side effects related to eating and sleeping were described and discussed.     

Characterizing the ADHD phenotype for genetic studies

The genetic study of ADHD has made considerable progress. Further developments in the field will be reliant in part on identifying the most appropriate phenotypes for genetic analysis. The use of both categorical and dimensional measures of symptoms related to ADHD has been productive. The use of multiple reporters is a valuable feature of the characterization of psychopathology in children. It is argued that the use of aggregated measures to characterize the ADHD phenotype, particularly to establish its pervasiveness, is desirable. The recognition of the multiple comorbidities of ADHD can help to isolate more specific genetic influences. In relation to both reading disability and conduct disorder there is evidence that genes may be involved in the comorbid condition that are different from pure ADHD. To date, progress with the investigation of endophenotypes for ADHD has been disappointing. It is suggested that extending such studies beyond cognitive underpinnings to include physiological and metabolic markers might facilitate progress.     

Mathematical problem solving and working memory in children with learning disabilities: both executive and phonological processes are important

The purpose of this investigation was to explore the relationship between working memory (WM) and mathematical problem solving in children with learning disabilities (LD). Children with LD (age 11.5 years) were compared to chronologically age-matched (CA-M) and younger comprehension/computation achievement-matched children (age 8.9 years) on measures of verbal and visual-spatial WM, phonological processing, components of problem solving, and word-problem solving accuracy. The results showed that (1) children with LD were inferior on measures of word solution accuracy, components of problem solving, phonological processing, domain-general WM, and verbal WM when compared to children who were CA-M, (2) children with LD were comparable to younger children on all processing measures, except measures of domain-general WM, visual-spatial WM, phonemic deletion, and identifying problem goals, (3) measures of verbal and visual-spatial WM contributed significant variance to solution accuracy independent of phonological processing, and (4) the influence of WM on solution accuracy was mediated by long-term memory (LTM) processes related to the knowledge of algorithms. The results support the notion that information activated from LTM, rather than phonological processing, mediates the relationship between executive processing and solution accuracy in children with LD.     

Child and parent predictors of perceptions of parent--child relationship quality

OBJECTIVE/METHOD: Predictors of perceptions of parent-child relationship quality were examined for 175 children with ADHD, 119 comparison children, and parents of these children, drawn from the follow-up phase of the Multimodal Treatment Study of Children with ADHD. RESULTS/CONCLUSION: Children with ADHD perceived their mothers and fathers as more power assertive than comparison children. Children higher on depressive symptomatology also perceived their mothers and fathers as less warm and more power assertive. Mothers perceived themselves as more power assertive and fathers perceived themselves as less warm if they were higher on depressive symptomatology themselves or had children with ADHD or higher levels of depressive symptomatology. Several interactions indicated that the association between child factors and parental perceptions of warmth and power assertion often depended on parental depressive symptomatology. The findings resolve a previous contradiction in the literature regarding the relationship between child depressive symptoms and parental perceptions of parent-child relationship quality.     

Next Generation Sequencing is the Impetus for the Next Generation of Laboratory-Based Genetic Counselors

Next generation sequencing (NGS) is dramatically increasing the number of clinically available genetic tests and thus the number of patients in which such testing may be indicated. The complex nature and volume of the reported results requires professional interpretation of the testing in order to translate and synthesize the meaning and potential benefit to patients, and genetic counselors are uniquely suited to provide this service. The increased need for genetic counselors in this role, coupled with the time required and a limited number of trained and available counselors presents a challenge to current models for making genetic testing available to patients and their healthcare providers effectively and efficiently. The employment of genetic counselors at genetic/genomic laboratories is one model to expand the resources for providing this service. In this article, we briefly review the advent of NGS and its clinical applications, examine the core skills of genetic counselors and delineate the expanding roles and responsibilities of laboratory-based genetic counselors. We also propose changes to the genetic counseling training program curriculum to account for the increasing opportunities for genetic counselors to contribute and thrive within genetic testing laboratories.     

RESPONSE REPETITION AS AN ERROR‐CORRECTION PROCEDURE FOR ACQUISITION OF MATH FACTS AND MATH COMPUTATION

We used nonconcurrent and concurrent multiple baseline designs to evaluate the extent to which error correction with response repetition (RR) produced acquisition of math facts and correct math computation for four individuals diagnosed with intellectual disabilities. The results show that RR increased correct responding on (i) targeted math problems for three of four participants and (ii) math problems presented in alternative formats for two of two participants. The results are consistent with prior studies that used RR to increase correct sight‐word reading for individuals with intellectual disabilities. The findings are discussed in terms of how RR might be implemented in typical classroom settings. Copyright © 2011 John Wiley & Sons, Ltd.     

Career counselor training and supervision: role of the supervisory working alliance

The importance of career counseling within our educational and professional systems is clearly recognized, yet little attention has been directed toward explicating the career counseling supervision process. Research on personal–emotional counseling supervision has stressed the critical importance of the supervisory relationship. The purpose of this study was to better understand the nature and effect of the supervisory working alliance in the supervision of career counselors, using case study methodology. Results point to the importance of explicitly addressing the working alliance early in the work, exploration of affect in supervision, and cognizance of the power differential inherent in a training relationship.