Inverse association between dopaminergic neurotransmission and Iowa Gambling Task performance in pathological gamblers and healthy controls

Linnet, J., Møller, A., Peterson, E., Gjedde, A. & Doudet, D. (2011). Inverse association between dopaminergic neurotransmission and Iowa Gambling Task performance in pathological gamblers and healthy controls. Scandinavian Journal of Psychology 52, 28–34. The dopamine system is believed to affect gambling behavior in pathological gambling. Particularly, dopamine release in the ventral striatum appears to affect decision‐making in the disorder. This study investigated dopamine release in the ventral striatum in relation to gambling performance on the Iowa Gambling Task (IGT) in 16 Pathological Gamblers (PG) and 14 Healthy Controls (HC). We used Positron Emission Tomography (PET) to measure the binding potential of [¹¹C] raclopride to dopamine D2/3 receptors during a baseline and gambling condition. We hypothesized that decreased raclopride binding potentials in the ventral striatum during gambling (indicating dopamine release) would be associated with higher IGT performance in Healthy Controls, but lower IGT performance in Pathological Gamblers. The results showed that Pathological Gamblers with dopamine release in the ventral striatum had significantly lower IGT performance than Healthy Controls. Furthermore, dopamine release was associated with significantly higher IGT performance in Healthy Controls and significantly lower IGT performance in Pathological Gamblers. The results suggest that dopamine release is involved both in adaptive and maladaptive decision‐making. These findings may contribute to a better understanding of dopaminergic dysfunctions in pathological gambling and substance related addictions.     

The dimensionality of dependent personality disorder

The criteria for dependent personality disorder (DPD) in DSM-IV appear to fall into two categories: dependent and attachment behaviors. The relevance of this division was evaluated in a sample of 182 patients admitted to a national Norwegian psychiatric hospital. Principal Components Analysis of all items belonging to the most frequent personality diagnoses revealed six components. The items for DPD formed two components, labeled attachment/abandonment and dependency/incompetence. Two criteria for borderline personality disorder also loaded on the attachment/abandonment component, while six criteria for avoidant personality disorder loaded on the dependency/incompetence component. Early Maladaptive Schemas of abandonment and failure correlated significantly higher with the attachment/abandonment component than with the dependency/incompetence component.     

Communication with former romantic partners and current relationship outcomes among college students

This research investigates individual and contextual differences underlying postdissolution friendships by considering communication with former romantic partners among individuals in new romantic relationships. Two studies demonstrate the prevalence, determinants, and implications of former partner communication for the current relationship. Study 1 showed that approximately 40% of individuals in relationships communicate with a former partner and highlighted differences between those who communicate and those who do not. Study 2 factor analyzed reasons why people communicate with former partners and examined how the reasons are differentially associated with current relationship functioning. In general, results support the notion that under certain circumstances and for certain individuals, communication with former partners can have deleterious influences on one's current relationship.     

Fatigue, cognitive functioning and psychological distress in Marfan syndrome, a pilot study

Marfan patients report fatigue as a major subjective complaint. We found no studies exploring the subject. The aim of this study was in a strictly defined Marfan population to assess self-reported fatigue, cognitive functions and psychological distress, correlations among them and correlations to visual acuity, joint hypermobility and use of beta-blockers. Sixteen subjects aged 18 - 30 years, fulfilling the Gent criteria, were assessed with the Fatigue Severity Scale, Fatigue Questionnaire, a comprehensive battery of neuropsychological tests and the General Health Questionnaire (GHQ). Self-reported fatigue was comparable with fatigue reported in other severe chronic diseases and disabilities, and was primarily in the mental/psychological domain. Psychological distress was higher than expected compared with the population at large. All neuropsychological test results were within the normal range, except for tests of visuo-motor coordination and speed of information processing. There was a significant inverse correlation between Fatigue Questionnaire ratings and some neuropsychological tests. Fatigue seems to be a serious problem for persons with Marfan syndrome and seems related to some areas of cognitive functioning. We found no overall impairment in cognitive functioning, but slightly reduced speed of information processing. Reduced visuo-motor coordination could be explained by impaired visual acuity.     

Bad company tamed

Neo-Fregean logicism seeks to base mathematics on abstraction principles. But the acceptable abstraction principles are surrounded by unacceptable (indeed often paradoxical) ones. This is the “bad company problem.” In this introduction I first provide a brief historical overview of the problem. Then I outline the main responses that are currently being debated. In the course of doing so I provide summaries of the contributions to this special issue.     

Infant Socioeconomic Position and Quality of Life in Midlife: A 50-Year Follow-Up Study of 2079 Individuals in Denmark

Applied Research in Quality of Life - During the last decades, an important line of public health research has focused on the influence of socioeconomic position (SEP) on the quality of life (QoL)...     

Cognitive Complexity and Dissociative Identity Disorder

Thirteen patients with dissociative identity disorder (DID), 13 with other mental disorders, and 10 nondiagnosed comparison participants were given individual grids. Results showed that displaying alternate personalities did not portend a more multidimensional level of thinking. Instead, the nonclinical comparison group had the greater degree of complexity in comparison to both clinical groups. A notable clinical observation was that DID patients, as compared to non-DID participants, had a greater understanding and speed in completing the grid. Findings are discussed in terms of the advantages of personal construct theory for conceptualizing the construct of dissociation.     

Childhood Adverse Experience: Yes or No? Mothers' Decision-Making Process When Responding to Survey Questions

The aim of this pilot study was to assess how difficult it is for mothers to answer questions regarding adversities their children might have experienced, and to investigate their considerations in the decision-making process. A nonrepresentative community sample of 628 mothers of 6- to 8-year-old children responded to an online survey. The mothers answered questions regarding adversities, rated the acceptability of these questions, and reported on any difficulties they had in responding. Based on the mothers' reports, qualitative analyses were conducted to identify metacategories of arguments. The study highlights the need for increased awareness of the complexity involved in soliciting information about adverse experiences in research and clinical settings, and for caution in interpreting epidemiological results in this field.