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81.
Most research on consumer choice assumes that decisions are usually made by individuals, and that these decisions are based on an individual's personal attitudes, beliefs, and preferences. Yet, much consumer behavior—from joint decisions to individual choices—is directly or indirectly shaped by people with whom we have some relationship. In this target article, we examine how each member in a relationship can affect how consumer decisions are made. After reviewing foundational work in the area, we introduce a powerful and statistically sophisticated methodology to study decisions within relationships—a dyadic framework of decision-making. We then discuss how the study of consumer decisions in relationships can be informed by different theories in the relationships field, including attachment, interdependence, social power, communal/exchange orientations, relationship norms, and evolutionary principles. By building on the seminal foundations of prior joint-decision making research with theories and methods from contemporary relationship science, we hope to facilitate the integration of the consumer and relationships literature to better understand and generate novel hypotheses about consumer decisions in relationships.  相似文献   
82.
The search for molecules that restrict synaptic plasticity in the brain has focused primarily on sensory systems during early postnatal development, as critical periods for inducing plasticity in sensory regions are easily defined. The recent discovery that Schaffer collateral inputs to hippocampal area CA2 do not readily support canonical activity-dependent long-term potentiation (LTP) serves as a reminder that the capacity for synaptic modification is also regulated anatomically across different brain regions. Hippocampal CA2 shares features with other similarly "LTP-resistant" brain areas in that many of the genes linked to synaptic function and the associated proteins known to restrict synaptic plasticity are expressed there. Add to this a rich complement of receptors and signaling molecules permissive for induction of atypical forms of synaptic potentiation, and area CA2 becomes an ideal model system for studying specific modulators of brain plasticity. Additionally, recent evidence suggests that hippocampal CA2 is instrumental for certain forms of learning, memory, and social behavior, but the links between CA2-enriched molecules and putative CA2-dependent behaviors are only just beginning to be made. In this review, we offer a detailed look at what is currently known about the synaptic plasticity in this important, yet largely overlooked component of the hippocampus and consider how the study of CA2 may provide clues to understanding the molecular signals critical to the modulation of synaptic function in different brain regions and across different stages of development.  相似文献   
83.
Objective: Preclinical models, receptor localization, and genetic linkage data support the role of D4 receptors in the etiology of ADHD. This proof-of-concept study was designed to evaluate MK-0929, a selective D4 receptor antagonist as treatment for adult ADHD. Method: A randomized, double-blind, placebo-controlled, crossover study was conducted in adults with primary ADHD. The primary end point was changed from baseline in total score on the Adult ADHD Investigator Symptom Rating Scale following a 4-week treatment regimen. Additional measures included Clinical Global Impression-Severity Scale, Hospital Anxiety and Depression Scale, and Brown Attention Deficit Disorder Scale and D4 genotype analysis. Results: No statistically significant treatment differences were found between MK-0929 and placebo in any of the primary or secondary assessments. Conclusion: Results from this study suggest that blockade of the D4 receptor alone is not efficacious in the treatment of adult ADHD.  相似文献   
84.
ABSTRACT Chronic hyponatremia (CHN) has traditionally been considered asymptomatic. If symptoms are observed, they are often mistakenly attributed to the underlying disorder. However, in recent studies neuropsychological deficits have been associated with CHN. The authors sought to determine the association between CHN and motor deficits. They used previously collected data, and 41 subjects with hyponatremia were included. An exploratory factor analysis with principal component analysis (PCA) was performed (eigenvalues >1.0). Factor scores were generated for each subject based on the resultant PCA factor structure. Finally, partial correlations were computed to measure the degree of association between baseline serum sodium concentration [Na+] and individual neuropsychological factor scores with the effect of age removed. All significance tests were performed using 2-tailed comparisons with alpha level of p ≤ .05. A 3-factor model emerged accounting for 70.17% of the total variance, including 1 factor that loaded primarily with motor speed and reaction time. A significant correlation was observed between this motor factor and serum [Na+] (r = -.477, p = .002). These findings add to previous observations suggesting that CHN is associated with subtle yet harmful motor deficits.  相似文献   
85.
In order to clarify the problems of iterated (global) belief change it is useful to study simple cases, in particular consecutive contractions by sentences that are both logically and epistemically independent. Models in which the selection mechanism is kept constant are much more plausible in this case than what they are in general. One such model, namely uniform specified meet contraction, has the advantage of being closely connected with the AGM model. Its properties seem fairly adequate for the intended type of contraction. However, the revision operator based on it via the Levi identity collapses into an implausible operation that loses all old information when revising by new information. A weaker version, semi-uniform specified meet contraction, avoids the collapse but has the disadvantage of a remarkably weak logic. It is left as an open issue whether there is an intermediate class of contraction operators that yields a more satisfactory logic.  相似文献   
86.
87.
The association of characteristics of anthropometry, training, and previous experience with race time in 84 recreational, long-distance, inline skaters at the longest inline marathon in Europe (111 km), the Inline One-eleven in Switzerland, was investigated to identify predictor variables for performance. Age, duration per training unit, and personal best time were the only three variables related to race time in a multiple regression, while none of the 16 anthropometric variables were related. Anthropometric characteristics seem to be of no importance for a fast race time in a long-distance inline skating race in contrast to training volume and previous experience, when controlled with covariates. Improving performance in a long-distance inline skating race might be related to a high training volume and previous race experience. Also, doing such a race requires a parallel psychological effort, mental stamina, focus, and persistence. This may be reflected in the preparation and training for the event. Future studies should investigate what motivates these athletes to train and compete.  相似文献   
88.
Sven Dupré 《Synthese》2012,185(3):501-525
This paper argues that Kepler considered his work in optics as part of natural philosophy and that, consequently, he aimed at change within natural philosophy. Back-to-back with John Schuster’s claim that Descartes’ optics should be considered as a natural philosophical appropriation of innovative results in the tradition of practical and mixed mathematics the central claim of my paper is that Kepler’s theory of optical imagery, developed in his Paralipomena ad Vitellionem (1604), was the result of a move similar to Descartes’ by Kepler. My argument consists of three parts. First, Kepler borrowed a geometrical model and experiment of optical imagery from the mélange of mixed and practical mathematics provided in the works of the sixteenth-century mathematicians Ettore Ausonio and Giovanni Battista Della Porta. Second, Kepler criticized the Aristotelian theory of light and he developed his own alternative metaphysics. Third, Kepler used his natural philosophical assumptions about the nature of light to re-interpret the model of image formation taken from Della Porta’s work. Taken together, I portray Kepler’s theory of optical imagery as a natural philosophical appropriation of an innovative model of image formation developed in a sixteenth-century practical and mixed mathematical tradition which was not interested in questioning philosophical assumptions on the nature of light.  相似文献   
89.
We examined how a group's claim to moral superiority influences evaluations of rule‐breaking by ingroup members. Moral superiority was manipulated among researchers (Study 1) and British citizens (Study 2), after which group members were presented with ingroup rule‐breakers: a researcher violating ethical rules (Study 1) and British soldiers abusing Iraqi prisoners (Study 2). In both studies, higher and lower identifiers in the control condition perceived the rule‐breaking as equally damaging, evaluated the rule‐breakers equally negatively and recommended equally harsh punishments. When the group had taken the moral high ground, lower identifiers perceived the rule‐breaking as more damaging than did higher identifiers. In addition, higher identifiers evaluated the rule‐breakers less negatively and recommended more lenient punishments. Results of mediation analyses demonstrated that negative evaluations of, and recommended punishment for, the rule‐breakers were explained by the perceived damage that their behaviour caused to the ingroup. Theoretical and practical implications are discussed. Copyright © 2011 John Wiley & Sons, Ltd.  相似文献   
90.
Faces are one of the most significant social stimuli and the processes underlying face perception are at the intersection of cognition, affect, and motivation. Vision scientists have had a tremendous success of mapping the regions for perceptual analysis of faces in posterior cortex. Based on evidence from (a) single unit recording studies in monkeys and humans; (b) human functional localizer studies; and (c) meta-analyses of neuroimaging studies, I argue that faces automatically evoke responses not only in these regions but also in the amygdala. I also argue that (a) a key property of faces represented in the amygdala is their typicality; and (b) one of the functions of the amygdala is to bias attention to atypical faces, which are associated with higher uncertainty. This framework is consistent with a number of other amygdala findings not involving faces, suggesting a general account for the role of the amygdala in perception.  相似文献   
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