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171.
    
To date, there is a lack of satisfactory inferential techniques for the analysis of multivariate data in factorial designs, when only minimal assumptions on the data can be made. Presently available methods are limited to very particular study designs or assume either multivariate normality or equal covariance matrices across groups, or they do not allow for an assessment of the interaction effects across within-subjects and between-subjects variables. We propose and methodologically validate a parametric bootstrap approach that does not suffer from any of the above limitations, and thus provides a rather general and comprehensive methodological route to inference for multivariate and repeated measures data. As an example application, we consider data from two different Alzheimer’s disease (AD) examination modalities that may be used for precise and early diagnosis, namely, single-photon emission computed tomography (SPECT) and electroencephalogram (EEG). These data violate the assumptions of classical multivariate methods, and indeed classical methods would not have yielded the same conclusions with regards to some of the factors involved.  相似文献   
172.
We investigated hemispheric differences and inter-hemispheric transfer of facilitation in automatic semantic priming, using prime-target pairs composed of words of the same category but not associated (e.g. skirt-glove), and a blank-target baseline condition. Reaction time and accuracy were measured at short (300 ms) intervals between prime and target onsets, using a go/no-go task to discriminate between word or non-word targets. Reaction times were facilitated more for target words presented in the right visual field (RVF) compared to the left visual field (LVF), and targets presented in RVF were primed in both visual fields, whereas targets presented in LVF were primed by primes in the LVF only. These results suggest that both hemispheres are capable of automatic priming at very short stimulus onset asymmetries (SOA), but cross-hemisphere priming occurs only in the left hemisphere.  相似文献   
173.
ABSTRACT— Previous studies have shown that rapid automatized naming (RAN) is a correlate of early reading skills; however, the interpretation of this finding remains controversial. We present the results from a 3-year longitudinal study. RAN, measured with nonalphabetic stimuli before reading instruction has begun, is a predictor of  later growth in reading fluency. After reading instruction has started, RAN continues to exert an influence on the development of reading fluency over the next 2 years. However, there is no evidence of a reciprocal influence of reading fluency on the growth of RAN skill. We suggest that RAN taps the integrity of left-hemisphere object-recognition and naming circuits that are recruited to function as a critical component of the child's developing visual word-recognition system.  相似文献   
174.
    
Arne Ness 《Erkenntnis》1937,7(1):198-210
Ohne Zusammenfassung  相似文献   
175.
For over a decade, prenatal screening for cystic fibrosis (CF) has been considered a model for the integration of genetic testing into routine medical practice. Data from pilot studies and public policy discourse have led to recommendations by some professional organizations that CF screening should be offered or made available to pregnant women and their partners, and to couples planning a pregnancy. It is crucial that genetic counselors gain thorough understanding of the complexities of CF and the implications of positive test results, so that they may serve as a reliable, educated referral base and resource for health care providers and their patients. While not all pregnant women will be referred for genetic counseling prior to CF carrier testing, genetic counselors often will be asked to counsel clients after they have a positive test result, or who are found to be at increased risk. Genetic counselors can play an important role in providing accurate and current information as well as support for patients informed decisions. These recommendations were created by a multicenter working group of genetic counselors with expertise in CF and are based on personal clinical experience, review of pertinent English language medical articles, and reports of expert committees. The recommendations should not be construed as dictating an exclusive course of management, nor does the use of such recommendations guarantee a particular outcome. These recommendations do not displace a health care providers professional judgment based on the clinical circumstances of a particular client.  相似文献   
176.
The subjective visual horizontal (SVH) and the subjective head transversal plane (STP) were measured by means of an adjustable luminous line in darkness during centrifuging. Subjects (N = 10) were seated upright, facing forward in a swing-out gondola. After acceleration of the centrifuge to 2G (vectorial sum of the earth's gravity and the centrifugal force; gondola inclination 60 degrees), subjects had to set the line either so that it was perceived as gravitoinertially horizontal (SVH) or so that it was perceived as parallel with the transversal ("horizontal") plane of the head (STP). Initially after acceleration, the SVH was tilted with respect to the gravitoinertial horizontal of the gondola (M = 16.6 degrees). This tilt was compensatory with respect to the gondola inclination. However, the STP was tilted in the opposite direction (M = 12.4 degrees), which might suggest a vestibular-induced distortion of the mental representation of one's own body. Similar results were obtained when measuring the subjective visual vertical (SVV) and the subjective midsagittal plane (SSP) in 5 subjects. The perceived roll angle (obtained as SVH-STP or SVV-SSP) was considerably larger than had previously been reported. Time constants for exponential decay of the tilt of the SVH or SVV were often 2-3 min, indicating a memory for semicircular canal information on changes in head orientation--a position-storage mechanism.  相似文献   
177.
The current study assesses the evidence for the association between several neighborhood social processes (collective efficacy and social disorder) and two important individual-level quality of life indicators, which are avoidance behaviour and mental health. In addition to these neighborhood characteristics, the study also assesses the impact of an individual’s social support network on these two outcomes. Hypotheses are derived from a theoretical framework that integrates insights from social capital theory, collective efficacy theory and broken windows theory. Hypotheses about both neighborhood- and individual-level effects are tested by applying multilevel analyses to data from the ‘Social capital and Well-being In Neighborhoods in Ghent’ (SWING) survey of 2011, which consists of face-to-face interviews among the adult population in the second largest municipality of Belgium. Results suggest that individuals living in neighborhoods with lower levels of social trust and higher levels of disorder report more avoidance behaviour. Neighborhood effects on mental health are rather negligible. Individuals who experience more social support report both a better mental health and fewer avoidance behaviour.  相似文献   
178.
Contrary to assumptions that changes in brain networks are possible only during crucial periods of development, research in the past decade has supported the idea of a permanently plastic brain. Novel experience, altered afferent input due to environmental changes and learning new skills are now recognized as modulators of brain function and underlying neuroanatomic circuitry. Given findings in experiments with animals and the recent discovery of increases in gray and white matter in the adult human brain as a result of learning, the old concept of cognitive reserve, that is the ability to reinforce brain volume in crucial areas and thus provide a greater threshold for age-dependent deficits, has been reinforced. The challenge we face is to unravel the exact nature of the dynamic structural alterations and, ultimately, to be able to use this knowledge for disease management. Understanding normative changes in brain structure that occur as a result of environmental changes and demands is pivotal to understanding the characteristic ability of the brain to adapt.  相似文献   
179.
Posttraumatic stress disorder (PTSD) is effectively treated with eye movement desensitization and reprocessing (EMDR) with patients making eye movements during recall of traumatic memories. Many therapists have replaced eye movements with bilateral beeps, but there are no data on the effects of beeps. Experimental studies suggest that eye movements may be beneficial because they tax working memory, especially the central executive component, but the presence/degree of taxation has not been assessed directly. Using discrimination Reaction Time (RT) tasks, we found that eye movements slow down RTs to auditive cues (experiment I), but binaural beeps do not slow down RTs to visual cues (experiment II). In an arguably more sensitive “Random Interval Repetition” task using tactile stimulation, working memory taxation of beeps and eye movements were directly compared. RTs slowed down during beeps, but the effects were much stronger for eye movements (experiment III). The same pattern was observed in a memory experiment with healthy volunteers (experiment IV): vividness of negative memories was reduced after both beeps and eye movements, but effects were larger for eye movements. Findings support a working memory account of EMDR and suggest that effects of beeps on negative memories are inferior to those of eye movements.  相似文献   
180.
Memory for a staged robbery was tested in two groups of participants witnessing the event either live (n = 62) or on video (n = 64). Immediately after the event participants filled out a questionnaire probing memory with emphasis on the timing of the event and robber characteristics. The results showed that participants who watched a video recording of the event reported more details and with a higher accuracy than participants who were present on the scene, but the pattern of memory errors were similar in the two conditions. It is concluded that laboratory experiments may overestimate the memory of eyewitnesses but are otherwise able to simulate essential aspects of memory performance in naturalistic contexts.  相似文献   
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