Metabotropic glutamate receptors (mGluRs) are known to play a role in synaptic plasticity and learning. We have previously shown that mGluR7 deletion in mice produces a selective working memory (WM) impairment, while other types of memory such as reference memory remain unaffected. Since WM has been associated with Theta activity (6-12 Hz) in EEGs, and since EEG abnormalities have been observed in these mice before, we studied the effect of mGluR7 gene ablation on EEG activity in the hippocampus, in particular in the Theta range, during performance of a WM task. In an eight-arm maze with four arms baited, mGluR7 knock-out (KO) and wild-type mice committed the same number of reference memory errors, whereas KOs committed more WM errors. While performing the task, KO mice showed substantially higher Theta amplitudes, and the ratio of Theta to overall EEG power was much increased. No change was seen in the Delta (0-5 Hz), or Gamma (30-40 Hz) EEG bands compared with controls. When recording EEGs during periods of rest in the home cages, no difference was seen between groups. These findings suggest that mGluR7 is important for modulation and control of Theta activity. Since only WM was affected, and only the Theta range of EEG activity was altered, these results show a correlation between Theta rhythm and WM performance, and therefore support the concept that Theta activity in the hippocampus is involved in WM storage. 相似文献
There is conflicting evidence pertaining to whether or not neurocognitive task performance at baseline predicts treatment response in obsessive-compulsive disorder (OCD). In the present study, we administered a set of executive neurocognitive tests with a putative sensitivity for treatment outcome to a sample of 138 OCD patients. Additionally, subjective neurocognitive dysfunction was determined via a questionnaire. All patients participated in a cognitive-behavioural treatment program (CBT). Results showed that responders (n = 73) did not differ from non-responders (n = 65) on any of the parameters except for decreased performance on the delayed alternation test (p < .1, effect size: .61). A subsidiary analysis revealed that slowing on the Trail-Making Test A and an enhanced rate of perserveration errors on the Wisconsin Card Sorting Test predicted poor outcome for the treatment of compulsions. It is concluded that neurocognitive impairment does not represent a reliable early warning sign for non-response to CBT. 相似文献
Performance in 2 versions of a computer-animated task was compared. Participants either indicated the time of arrival of a target that rolled off a horizontal surface and fell--hidden from view--onto a landing point (production task) or judged flight time on a rating scale (judgment task). As predicted, performance was significantly better in the production task (Experiment 1), in which imagery of object motion probably replaced reasoning processes. Participants who exhibited eye movements suggesting mental tracking performed particularly well in the production task (Experiment 2). There was, however, no decrement in performance when participants were asked to fixate the point where the target disappeared. For motion duration estimations, eye movements seem to be only a by-product of mental tracking. 相似文献
Auditory, visual, and cross-modal negative priming was investigated using a task in which participants judged whether stimuli were animals or musical instruments. Negative priming was observed, but only if the attended and the ignored primes evoked different responses. This pattern—negative priming after conflict, but not after nonconflict, primes—was demonstrated with visual stimuli and replicated with auditory stimuli, as well as across modalities, both auditory to visual and visual to auditory. Implications for theories of negative priming are discussed. 相似文献
In a 2 × 2 × 2 crossed factorial design, trained or untrained subjects viewed a videotape and evaluated performance on either a familiar (college lecturer) or unfamiliar (salesperson) job. Prior to viewing the videotape, some subjects reviewed positive information about the ratee's prior performance, whereas other subjects did not review any prior performance information. To determine whether assimilation or contrast effects occurred, we compared ratings provided by subjects who reviewed positive information about prior performance with ratings provided by subjects who did not review any prior performance information. A three-way interaction was obtained. Ratings of performance on the familiar job by untrained or trained subjects revealed only a small assimilation effect. However, when rating performance on the unfamiliar job, a large assimilation effect was observed among untrained subjects, whereas a large contrast effect was observed among trained subjects. The results indicate that rater error training may reverse, rather than reduce or eliminate, rating errors that arise from knowledge of a ratee's prior performance. Implications for further understanding and reducing assimilation and contrast effects are discussed. 相似文献
In the first study subjects were given information about an applicant to graduate school and asked to rate his qualifications. The information experimentally varied (a) whether the school had an affirmative action policy, (b) the ethnicity of the applicant, and (c) whether the applicant was accepted or rejected. Based on Kelley's discussion of the discounting and augmentation principles, it was predicted that the minority applicant would be rated as less qualified when the university was committed to an affirmative action program. The reverse pattern was predicted for the non-minority applicant. The results supported the first prediction but not the second. Experiment 2 was designed to eliminate alternative interpretations of the data and the same results were found. Possible interpretations for the failure of affirmative action in affecting the ratings of nonminority applicants are discussed. 相似文献
This study examined the relationships of perceived discrimination and religious coping with hypertension in a sample of Black and White Seventh-day Adventists. Data come from a community-based sample of 6128 White American, 2253 African American and 927 Caribbean American adults (67% women; mean age = 62.9 years). Results indicate lifetime unfair treatment was significantly associated with hypertension regardless of race/ethnicity. Positive religious coping was associated with lower odds of hypertension and did not interact with unfair treatment. Both positive and negative religious coping were indirectly associated with increased hypertension risk through an increase in perceived discrimination.