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71.
States develop specific protocols for cystic fibrosis (CF) newborn screening to reflect the population served. We hypothesized that mutation distribution and detection rates would differ between Hispanic and non-Hispanic CF patients diagnosed by IL newborn screen with more Hispanic infants carrying mutations not detected by the state panel. Data from CF cases diagnosed via newborn screen in IL between 3/1/2008 and 10/31/2010 were reviewed. More Hispanic infants with CF had one or more undefined mutations after screening, in comparison to non-Hispanic Caucasian patients (40% vs. 9.5%; p?0.002). The risk of having a positive diagnosis of CF with only one mutation noted by positive newborn screen increases 2-fold in Hispanic Caucasian versus non-Hispanic Caucasian infants (5% vs. 2.4%). Health care providers must be aware of the limitations of CF newborn screening to ensure appropriate counseling and prompt referral for a positive newborn screen, even when zero or one mutations are identified. 相似文献
72.
The purpose of this study was to explore relations between principals?? self-efficacy, burnout, job satisfaction and principals?? motivation to quit. Principal self-efficacy was measured by a recently developed multidimensional scale called the Norwegian Principal Self-Efficacy Scale. Burnout was measured by a modified version of the Maslach Burnout Inventory. Job satisfaction and motivation to quit were measured by two scales developed for the purpose of this study, respectively. Participant in the study were 1,818 principals from the population of Norwegian principals. Data was collected by means of an electronic questionnaire. Two structural equation models were tested which specified principal self-efficacy as an exogenous variable and burnout, job satisfaction and motivation to quit as endogenous variables. The data was analyzed by means of SEM analysis for latent variables using the AMOS 18 program. Both models had acceptable fit to data. The results revealed that principal self-efficacy was positively related to job satisfaction and motivation to quit and negatively related to burnout. Burnout and job satisfaction were negatively related. Burnout was positively related to motivation to quit whereas job satisfaction was negatively related. The study highlights important relations between self-efficacy, burnout, job satisfaction and motivation to quit and extends the literature on principal self-efficacy and its relation to other concepts. The results of the study are discussed together with limitations and suggestions for further research. 相似文献
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MacLeod Susanna Schneider Luke H. McCabe Randi E. 《Journal of psychopathology and behavioral assessment》2022,44(3):826-835
Journal of Psychopathology and Behavioral Assessment - With the publication of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition, the American Psychiatric Association... 相似文献
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Susanna Pietropaolo Joram Feldon Benjamin K. Yee 《Cognitive, affective & behavioral neuroscience》2014,14(3):996-1008
Although the impacts of environmental enrichment (EE) in several genetic models of Alzheimer’s disease (AD) have been documented, the focus has remained predominantly on cognition. Few have investigated the expression of emotional phenotypes that mimic the notable affective features in AD. Here, we studied the interaction between EE and the coexpression of three genetic risk factors (mutations) for AD. In a longitudinal design, 3×Tg-AD mutants and wild type controls were compared at 6–7 months and subsequently at 12–13 months of age. Under standard housing, phenotypes of heightened anxiety levels were identified in the 3×Tg-AD mice in the elevated plus maze and open-field tests. Such trait differences between genotypes were substantially diminished under EE housing, which was attributable to the anxiolytic impact of EE on the mutant mice as much as the anxiogenic impact of EE on the wild type mice. In contrast, the phenotypes in learned fear were not significantly modified by EE in the tests of Pavlovian freezing and conditioned active avoidance conducted at either age. Rearing under EE thus has uncovered a novel distinction between innate and acquired expressions of fear response in the 3×Tg-AD mouse model that might be relevant to the mental health management of AD. 相似文献
76.
In the study entitled “Web usability evaluation with screen reader users: Implementation of the Partial Concurrent Thinking
Aloud technique” (Federici et al. 2010), we have proposed a modified protocol of usability evaluation technique for blind users, which integrates the features of
the concurrent and the retrospective techniques. This new technique, called partial concurrent thinking aloud (PCTA), while
respecting the properties of classic verbal protocols, overcomes the structural interference and the limits of concurrent
and retrospective protocols when used with screen reader users. In order to facilitate understanding and acquisition of the
PCTA’s technique for practitioners and researchers, we have video recorded three different verbal protocols by visualizing
five experimental sections. In the first two videos, we have compared a concurrent with a retrospective’s verbal protocol
of a sighted user, showing the difference of the verbalizations provided by the user in these two conditions. The third video
shows the structural interference of the screen reader, during a blind user concurrent thinking aloud. In the last two videos,
we show the difference of a blind user behaviour when PCTA or retrospective protocol is adopted. The videos clearly visualize
the advantage of the PCTA use in respect of the two other protocols. In conclusion, the visualization of the PCTA technique
confirms that this new verbal protocol promotes and guarantees a more user-driven usability assessment with disabled people,
by better involving screen reader users, overcoming the structural interference and the limits of the concurrent and retrospective
protocols. 相似文献
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Susanna Federici-Nebbiosi Ph.D. 《Psychoanalytic Dialogues》2013,23(1):47-57
In this discussion I agree with Anthony Bass, who shows how the analytic frame has properties that involve both the process and the structure, and I suggest replacing the term structure with the term constraints. Bass considers analytic frames as contexts: Different frames organize different contexts of experience. He says that the frame is cocreated by patient and analyst and evolves over time. I think that Dafna's case presented by Ilana Laor is a good example of this aspect. I agree with Laor, who shows how the frame reflects the negotiation process between patient and analyst, emphasizing that this process itself is therapeutic. Following Bass I emphasize that a polarization between stability versus flexibility should be replaced by the dialectic between stability and flexibility. I conclude wondering how Bass's and Laor's “wisdom” regarding flexibility and elasticity can be passed over to younger psychoanalysts who are beginning their clinical work. 相似文献
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