Communicating BRCA1/2 genetic test results within the family: a qualitative analysis

Genetic testing for BRCA1/2 mutations associated with hereditary breast and ovarian cancer reveals significant risk information about one's chances of developing cancer. It is important to study communication processes in families where members are undergoing genetic testing because the information received is crucial not just to the individual concerned but also to other members of the biological family. This study investigates family communication of BRCA1/2 test results from both the informants' and recipients' perspectives. A total of 10 female patients and 22 of their relatives were interviewed. Patients' and their relatives described feelings of responsibility for sharing genetic information within the family to enable others to reduce their risks of developing cancer. However, there were limits to an individuals' responsibility once key family members had been informed, who then had to take responsibility for continuing dissemination of information. Whilst there was an implicit responsibility to inform the family of a mutation, information was edited or withheld in the best interest of relatives, dependent upon their perceived emotional readiness, resilience and current life stage and circumstances. The pre-existing family culture and the impact previous cancer diagnoses had upon the family also influenced the process of communication. Findings are discussed in relation to extant literature and implications for clinical practice are considered.     

Latent trait models in the study of intelligence

This article examines the potential contribution of latent trait models to the study of intelligence. Nontechnical introductions to both unidimensional and multidimensional latent trait models are given, and possible research applications are considered. Latent trait models are shown to resolve several measurement problems in studies of intellectual change, including ability modification studies and life-span development studies. Furthermore, under certain conditions, latent trait models are found useful for construct validation research, since they can represent an individual differences model of cognitive processing on ability test items. Multidimensional latent trait models are shown to be especially useful as processing models, because they can be used to test alternative multiple component theories of test item processing. Furthermore, multidimensional models can be used to decompose test item difficulty into component contributions and estimate individual differences in processing abilities.     

A study of the effects of cranial electrical stimulation on attention and concentration

There have been several anecdotal accounts that cranial electrical stimulation (CES) enhances attention and the ability to learn new tasks in a normal population, but only one published investigation confirms that CES improves attention using the Alpha Stim CES (Madden and Kirsch, 1987). The purpose of this study was to corroborate the findings of Madden and Kirsch, using more precise measures of attention, such as a Continuous Performance Test (CPT). A pretest and posttest CPT was given to two groups using the LISS CES device. The control group consisted of twenty-one subjects who received the placebo treatment. The experimental group of thirty-one subjects received twenty minutes of CES. Four measures of the CPT show significant gains in attention: Number of Hits,p=.010 Hit RT ISI Change,p=.016, Risk Taking,p=.055; and Attentiveness,p=.054. Based on subjects who demonstrated improvement by one standard deviation on two different measures of the CPT, thirty-one percent of the experimental group improved versus four percent of the control group. The use of CES as a method of increasing attention is a promising are that requires further investigation.     

DEFINITIONAL RESEARCH ON AFRICAN AMERICAN STUDENTS AND SEXUAL HARASSMENT

A total of 100 African American undergraduate students were given the Sexual Experiences Questionnaire (SEQ) (Fitzgerald et al., 1988) and an open-ended question assessing experiences of sexual harassment. Results showed a significant frequency of sexual imposition (19%), particularly sexual touching. Participants also clearly delineated a new category of sexual harassment previously untapped by largely Caucasian studies: comments or sexual attention based solely on racial stereotypes or racially based physical features. In conclusion, the reported differences with regard to experiences and definitions of sexual harassment indicate that previous assumptions of homogeneity of experience (with Caucasian women being the standard) appear to be incorrect.     

Physiological and symptom responses to hyperventilation: A comparison of frequent and infrequent panickers

Ten subjects with panic disorder and ten subjects with infrequent panic attacks were assessed during 2 min of voluntary hyperventilation using four measures of physiological arousal (heart rate, upper trapezious EMG, skin conductance, and digital skin temperature). Immediately following hyperventilation, subjects were asked to rate their degree of distress on 13 panic symptoms, derived from DSM-III criteria for panic disorder. Results indicated that frequent panickers had significant overall elevations in trapezious EMG, relative to infrequent panickers, and demonstrated a slight increase in muscle tension following hyperventilation. In contrast, infrequent panickers showed a trend toward greater vasodilation preceding and during hyperventilation, with subsequent vasoconstriction upon resumption of normal breathing. Increases in skin conductance and heart rate were noted for both samples during hyperventilation, as reported in prior research. Symptom distress ratings indicated that the infrequent panickers reported significantly greater distress from dizziness and trembling in response to overbreathing, contrary to prediction. Implications of these findings are discussed in light of current accounts of cognitive and physiological factors in the etiology of panic attacks and panic disorder.This research was supported by Biomedical Research Support Grant #507RR07147, National Institutes of Health.