Studies in analytic philosophy in China

This essay explores the history of studies in analytical philosophy in China since the beginning of the last century, by dividing into three phases. It shows that, in these phases, analytic philosophy was always at a disadvantage in confronting serious challenges coming from both Chinese traditional philosophy and modern philosophical trends. The authors argue that Chinese philosophers have both done preliminary studies and offered their own analyses of various problems as well as some new applications of analytic philosophy especially in the latest period. Meanwhile, Chinese traditional philosophy was always trying to adjust its cultural mentality in the struggle with analytic philosophy, and accommodated in its own way the rationalistic spirit and scientific method represented in analytic philosophy.     

White Matter: Organization and Functional Relevance

Norman Geschwind’s landmark paper in 1965, “Disconnexion Syndromes in Animals and Man,” inspired a generation of investigators to consider the effects of focal brain lesions disrupting higher brain functions. Although Geschwind viewed disconnection as resulting from either white or gray matter lesions, his signature article drew upon the insights of 19th century neurologists and firmly established white matter within the vocabulary of behavioral neurology, neuropsychology, and cognitive neuroscience. This influence, and the advent of sensitive neuroimaging techniques later in the 20th century, led to white matter gradually gaining more attention as an essential component of distributed neural networks subserving cognition and emotion. Today, whereas focal white matter lesions remain central to the pathogenesis of classic neurobehavioral syndromes, diffuse white matter involvement is regarded as increasingly relevant to a wide variety of dementia syndromes and a host of neuropsychiatric disorders as well. In parallel, better understanding of the neurobiology of brain white matter at all ages has been achieved. While much remains to be explored, a general conceptual formulation is that white matter supports information transfer to complement the information processing carried out by gray matter. As knowledge of the organization and functional relevance of white matter continues to advance, improved understanding of the role of myelinated tracts in higher function can be anticipated, and with it many clinical benefits.     

Crossmodal action selection: Evidence from dual-task compatibility

Response-related mechanisms of multitasking were studied by analyzing simultaneous processing of responses in different modalities (i.e., crossmodal action). Participants responded to a single auditory stimulus with a saccade, a manual response (single-task conditions), or both (dual-task condition). We used a spatially incompatible stimulus-response mapping for one task, but not for the other. Critically, inverting these mappings varied temporal task overlap in dual-task conditions while keeping spatial incompatibility across responses constant. Unlike previous paradigms, temporal task overlap was manipulated without utilizing sequential stimulus presentation, which might induce strategic serial processing. The results revealed dual-task costs, but these were not affected by an increase of temporal task overlap. This finding is evidence for parallel response selection in multitasking. We propose that crossmodal action is processed by a central mapping-selection mechanism in working memory and that the dual-task costs are mainly caused by mapping-related crosstalk.     

The epistemology and ethics of chronic disease research: Further lessons from ECMO

Robert Truog describes the controversial randomized controlled trials (RCTs) of extracorporeal membrane oxygenation (ECMO) therapy in newborns. Because early results with ECMO indicated that it might be a great advance, saving many lives, Truog argues that ECMO should not have been tested using RCTs, but that a long-term, large-scale observational study of actual clinical practice should have been conducted instead. Central to Truog’s argument, however, is the idea that ECMO is an unusual case. Thus, it is an open question whether Truog’s conclusions can be extended to other areas of medical research. In this paper, I look at epistemological and ethical issues arising in the care of patients with chronic diseases, using ECMO as a starting point. Both the similarities and the dissimilarities of these two cases highlight important issues in biomedical research and support a conclusion similar to Truog’s. Observational studies of clinical practice provide the best evidence to inform the treatment of patients with chronic disease.     

Hierarchical Bayes Models for Response Time Data

Human response time (RT) data are widely used in experimental psychology to evaluate theories of mental processing. Typically, the data constitute the times taken by a subject to react to a succession of stimuli under varying experimental conditions. Because of the sequential nature of the experiments there are trends (due to learning, fatigue, fluctuations in attentional state, etc.) and serial dependencies in the data. The data also exhibit extreme observations that can be attributed to lapses, intrusions from outside the experiment, and errors occurring during the experiment. Any adequate analysis should account for these features and quantify them accurately. Recognizing that Bayesian hierarchical models are an excellent modeling tool, we focus on the elaboration of a realistic likelihood for the data and on a careful assessment of the quality of fit that it provides. We judge quality of fit in terms of the predictive performance of the model. We demonstrate how simple Bayesian hierarchical models can be built for several RT sequences, differentiating between subject-specific and condition-specific effects.     

Sunscreens with Titanium Dioxide (TiO<Subscript>2</Subscript>) Nano-Particles: A Societal Experiment

The risks of novel technologies, such as nano(bio)technology cannot be fully assessed due to the existing uncertainties surrounding their introduction into society. Consequently, the introduction of innovative technologies can be conceptualised as a societal experiment, which is a helpful approach to evaluate moral acceptability. This approach is illustrated with the marketing of sunscreens containing nano-sized titanium dioxide (TiO₂) particles. We argue that the marketing of this TiO₂ nanomaterial in UV protective cosmetics is ethically undesirable, since it violates four reasonable moral conditions for societal experimentation (absence of alternatives, controllability, limited informed consent, and continuing evaluation). To remedy the current way nano-sized TiO₂ containing sunscreens are utilised, we suggest five complementing actions (closing the gap, setup monitoring tools, continuing review, designing for safety, and regulative improvements) so that its marketing can become more acceptable.     

Hidden Mission of the Psyche in Abuse and Addiction

Traumatic experiences can become the central mental content in our psychic structure and can deeply mark all our later perceptions and experiences of our surroundings. We can claim something similar also for addictions of all kinds. In this article, we will demonstrate that recurring traumatic experiences and abuse as well as addiction represent a hidden mission of psyche for resolution and a great cry of longing for salvation.     

Multidimensional Latent Markov Models in a Developmental Study of Inhibitory Control and Attentional Flexibility in Early Childhood

We demonstrate the use of a multidimensional extension of the latent Markov model to analyse data from studies with repeated binary responses in developmental psychology. In particular, we consider an experiment based on a battery of tests which was administered to pre-school children, at three time periods, in order to measure their inhibitory control (IC) and attentional flexibility (AF) abilities. Our model represents these abilities by two latent traits which are associated to each state of a latent Markov chain. The conditional distribution of the test outcomes given the latent process depends on these abilities through a multidimensional one-parameter or two-parameter logistic parameterisation. We outline an EM algorithm for likelihood inference on the model parameters; we also focus on likelihood ratio testing of hypotheses on the dimensionality of the model and on the transition matrices of the latent process. Through the approach based on the proposed model, we find evidence that supports that IC and AF can be conceptualised as distinct constructs. Furthermore, we outline developmental aspects of participants’ performance on these abilities based on inspection of the estimated transition matrices.     

Humanizing Personhood

This paper explores the debate between personists, who argue that the concept of a person if of central importance for moral thought, and personists, who argue that the concept of a human being is of greater moral significance. On the one hand, it argues that normative naturalism, the most ambitious defense of the humanist position, fails to identify moral standards with standards of human behavior and thereby fails to undermine the moral significance of personhood. At the same time, it contends that a more focused attention on the morally relevant features of human life may indeed play a crucial role in enhancing our moral understanding.     

Natality and mortality: rethinking death with Cavarero

In this article I rethink death and mortality on the basis of birth and natality, drawing on the work of the Italian feminist philosopher Adriana Cavarero. She understands birth to be the corporeal event whereby a unique person emerges from the mother’s body into the common world. On this basis Cavarero reconceives death as consisting in bodily dissolution and re-integration into cosmic life. This impersonal conception of death coheres badly with her view that birth is never exclusively material but always has ontological significance as the appearance of someone new and singular in the world of relations with others. This view of birth calls for a relational conception of death, which I develop in this article. On this conception, death is always collective, affecting all those with whom the one who dies has maintained relations: As such, our different deaths shade into one another. Moreover, because each person is unique in virtue of consisting of a unique web of relations with others, death always happens to persons as webs of relations. Death is relational in this way as a corporeal, and specifically biological, phenomenon, to which we are subject as bodily beings and as interdependent living organisms. I explore this with reference to Simone de Beauvoir’s memoir of her mother’s death from cancer. Finally I argue that, on this relational conception, death is something to be feared.