Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear

Extinction of conditioned fear is an important model both of inhibitory learning and of behavior therapy for human anxiety disorders. Like other forms of learning, extinction learning is long-lasting and depends on regulated gene expression. Epigenetic mechanisms make an important contribution to persistent changes in gene expression; therefore, in these studies, we have investigated whether epigenetic regulation of gene expression contributes to fear extinction. Since brain-derived neurotrophic factor (BDNF) is crucial for synaptic plasticity and for the maintenance of long-term memory, we examined histone modifications around two BDNF gene promoters after extinction of cued fear, as potential targets of learning-induced epigenetic regulation of gene expression. Valproic acid (VPA), used for some time as an anticonvulsant and a mood stabilizer, modulates the expression of BDNF, and is a histone deacetylase (HDAC) inhibitor. Here, we report that extinction of conditioned fear is accompanied by a significant increase in histone H4 acetylation around the BDNF P4 gene promoter and increases in BDNF exon I and IV mRNA expression in prefrontal cortex, that VPA enhances long-term memory for extinction because of its HDAC inhibitor effects, and that VPA potentiates the effect of weak extinction training on histone H4 acetylation around both the BDNF P1 and P4 gene promoters and on BDNF exon IV mRNA expression. These results suggest a relationship between histone H4 modification, epigenetic regulation of BDNF gene expression, and long-term memory for extinction of conditioned fear. In addition, they suggest that HDAC inhibitors may become a useful pharmacological adjunct to psychotherapy for human anxiety disorders.     

Virtual environment training system for rehabilitation of stroke patients with unilateral neglect: crossing the virtual street.

In this paper, we propose a system for training of stroke patients with unilateral neglect by using technology of virtual reality (VR). The proposed system is designed to compensate for unilateral neglect. This system contains the calibration of unilateral neglect and the training of this disease. The calibration procedure is implemented by aligning the virtual object at a subjective middle line. The training procedure is implemented by completing the missions that are used to keep the virtual avatar safe during crossing the street in a virtual environment. The results of this study show that the proposed system is effective to train unilateral neglect. The left to right ratio scores extracted from this system gradually decrease as the sessions of training are repeated. To validate the VR system parameters, the parameters are analyzed by correlation with those of traditional unilateral neglect assessment methods (such as the line bisection test and the cancellation test).     

SAS and SPSS macros to calculate standardized Cronbach’s alpha using the upper bound of the phi coefficient for dichotomous items

Cronbach’s α is widely used in social science research to estimate the internal consistency of reliability of a measurement scale. However, when items are not strictly parallel, the Cronbach’s α coefficient provides a lower-bound estimate of true reliability, and this estimate may be further biased downward when items are dichotomous. The estimation of standardized Cronbach’s α for a scale with dichotomous items can be improved by using the upper bound of coefficient ϕ. SAS and SPSS macros have been developed in this article to obtain standardized Cronbach’s α via this method. The simulation analysis showed that Cronbach’s α from upper-bound ϕ might be appropriate for estimating the real reliability when standardized Cronbach’s α is problematic.     

Building social support for adolescents with suicidal ideation: implications for school guidance and counselling

This study involved interviews with 13 adolescents with high levels of suicidal ideation. It aimed to understand how these adolescents perceived their family, school and peer relationships, and how they perceived these systems as their support. Comparison between adolescents with severe and mild suicidal ideation showed that the family, school and peers could act as effective support systems in times of stress. A close interpersonal relationship was the key factor in unlocking these support systems. The school as a support system was highlighted. Implications for school guidance and counselling to strengthen the social support of adolescents and adolescents' resiliency were discussed.     

儿童孤独感与同伴关系、社会行为及社交自我知觉的研究

本研究采用同伴提名法和问卷调查法对3-6年级儿童共600名进行了研究,试图考察儿童孤独感与同伴关系、社会行为及社交自我知觉的关系。结果表明:(1)受欢迎组儿童的孤独感显著低于被拒绝组、被忽视组、有争议组和一般组;一般组儿童的孤独感显著低于被拒绝组和被忽视组。(2)社交自我知觉较高的儿童的孤独感显著低于社交自我知觉一般和较低的儿童,社交自我知觉一般的儿童的孤独感显著低于社交自我知觉较低的儿童。(3)高攻击型儿童的孤独感高于低攻击型儿童,但没有达到显著水平;高退缩型儿童的孤独感显著高于一般退缩型和低退缩型儿童,一般退缩型儿童的孤独感显著高于低退缩型的儿童。     

Effects of model-based and memory-based processing on speed and accuracy of grammar string generation

Learners are able to use 2 different types of knowledge to perform a skill. One type is a conscious mental model, and the other is based on memories of instances. The authors conducted 3 experiments that manipulated training conditions designed to affect the availability of 1 or both types of knowledge about an artificial grammar. Participants were tested for both speed and accuracy of their ability to generate letter sequences. Results indicate that model-based training leads to slow accurate responding. Memory-based training leads to fast, less accurate responding and highest achievement when perfect accuracy was not required. Evidence supports participants' preference for using the memory-based mode when exposed to both types of training. Finally, the accuracy contributed by model-based training declined over a retention interval.     

The contributions of static visual cues, nonvisual cues, and optic flow in distance estimation

By systematically varying cue availability in the stimulus and response phases of a series of same-modality and cross-modality distance matching tasks, we examined the contributions of static visual information, idiothetic information, and optic flow information. The experiment was conducted in a large-scale, open, outdoor environment. Subjects were presented with information about a distance and were then required to turn 180 before producing a distance estimate. Distance encoding and responding occurred via: (i) visually perceived target distance, or (ii) traversed distance through either blindfolded locomotion or during sighted locomotion. The results demonstrated that subjects performed with similar accuracy across all conditions. In conditions in which the stimulus and the response were delivered in the same mode, when visual information was absent, constant error was minimal; whereas, when visual information was present, overestimation was observed. In conditions in which the stimulus and response modes differed, a consistent error pattern was observed. By systematically comparing complementary conditions, we found that the availability of visual information during locomotion (particularly optic flow) led to an 'under-perception' of movement relative to conditions in which visual information was absent during locomotion.     

蒯因彻底翻译的不确定性论题

蒯因在《语词和对象》这部著作中第一次提出了翻译的不确定性论题,这一论题的提出,引起了广泛的论证与反驳。通过分析蒯因本人对此论题的分析与论证,可以看出：翻译的不确定性论题是蒯因哲学体系中不可分割的一个部分,是对“经验论的两个教条”在语言中的继续批判,是“整体论”的逻辑发展,以及“本体论相对性”的理论前提。通过分析戴维森、普特南对此论题的回应,可以使我们对“彻底翻译不确定性论题”有一个更好的把握。     

Involuntary awareness and implicit priming: role of retrieval context

This study examined the role of retrieval context in implicit priming by manipulating percentage of word-stem index as shallow and deep processing while performing a word-stem completion task. 80 subjects were randomly divided into four groups each of 20 subjects: shallow processing or deep processing with few retrieval indices, and shallow processing or deep processing with many retrieval indices. Analysis indicated that proportion of word-stem completion was significantly higher for studied words than for nonstudied words in all four groups and that the subjects in the groups with many retrieval indices had a significantly increased proportion of word-stem completion between studied and nonstudied words than those in the groups with few retrieval indices. Postquestionnaire analysis indicated that more previously studied items were retrieved if many studied items were available during implicit word-stem completion and that only a small proportion of word-stem completion was finished with studied words by the subjects who were aware of the prior studied and test word relations in all four groups. It was concluded that having more studied words retrievable contributed to more being retrieved and that involuntary awareness had very limited influence on the priming in the implicit word-stem completion.     

朱熹论墨子之兼爱说

墨子的兼爱说被孟子攻击为“无父”。此后 ,儒家学者大多照着孟子说 ,既未能作出深入分析 ,也未能消除对兼爱无父说的疑惑。兼爱说所内涵的普遍人性理念和天地人一体的思想实际上已被宋代理学家融摄。出于严儒墨之辨的学派意识 ,朱熹重整兼爱无父说 ,同时也深入分析了兼爱说产生的主客观原因 ,对兼爱说作了较为客观的评价。