An open clinical trial of cognitive-behaviour therapy in children and adolescents with obsessive-compulsive disorder administered in regular outpatient clinics

The aim of the present study was to examine the effectiveness of manual-guided cognitive-behaviour therapy (CBT) for childhood obsessive-compulsive disorder (OCD) administered within three regular, i.e., non-academic, Norwegian outpatient child psychiatric clinics. METHODS: A total of 28 youngsters, aged 8-17 with primary OCD entered the study. Assessment at intake included Norwegian versions of the K-SADS-PL, Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS), and a measure of OCD-specific functional impairment (Child OCD Impact Scale (COIS)). Therapy consisted of 12 manual-guided sessions with combined individual and family CBT-based interventions and was conducted by psychologists and physicians under training and supervision. Outcome was assessed after treatment and at 3- and 6-month follow-ups by means of the CY-BOCS, the Clinical Global Impression (CGI) and the CGI-Improvement scales, and the COIS. RESULTS: Twenty-four youngsters (86%) completed treatment and were available for the follow-up assessments. Significant improvements were found on all outcome measures after treatment, including a mean symptom reduction on the CY-BOCS of 60.6%, increasing to 68.8% at the 6-month follow-up. Estimates of within-group effect sizes showed strong effects of treatment. CONCLUSION: The results of the present study suggest that manual-guided CBT for childhood OCD can be successfully implemented in non-academic community child psychiatric settings with outcomes in accordance with previous findings from highly specialised university clinics.     

Reliability and validity of Job Content Questionnaire in Chinese petrochemical employees

To evaluate psychometric properties the Chinese (mainland) version of the 30-item Job Content Questionnaire was administered to 889 employees in 4 industries of PetroChina. A retest at 3 months with 296 randomly chosen employees showed reliabilities ranged from .76 to .93. Cronbach coefficients alpha for the 8 dimensions ranged from .43 to .88, indicating that the Job Insecurity subscale had low internal consistency. Exploratory factor analysis showed 8 meaningful factors corresponding to the 8 theoretical dimensions of this questionnaire. This version has variable a but suitable retest to be a reliable and valid measure of job strain, applicable to the Chinese industrial working population of PetroChina.     

HERG钾通道抑制——祸兮？福兮？

过去的10多年,许多药物由于引起QT闯期延长被撤市或限制使用,原因可能是HERG钾通道受到抑制,可诱发致死性心律失常。抑制HERG钾通道的药物因而成为临床用药的潜在祸患。另一方面,HERG钾通道还参与癌症和骨骼肌萎缩的发病过程,提示HERG钾通道抑制荆可能对这些疾病具有潜在治疗价值。HERG钾通道抑制究竟是“祸”还是“福”呢？本文就这一现象进行讨论。     

胃肠道双重造影对胃肠道病变诊断的临床思维方法

从方法学原理的角度,通过对胃肠道双重造影征象分析和综合的辩证思维,经过整体和局部相结合,从一般到特殊,由现象到本质,全面客观,纵横联系的认识过程,探讨和研究胃肠道双重造影对胃肠道疾病诊断的科学思维方法,提高、改进影像科医生的临床思雏,对提高医疗水平有着重大的意义。     

脐血干细胞移植治疗肌萎缩侧索硬化伦理问题的思考

肌萎缩侧索硬化症是神经系统一种致死性疾病,目前尚无有效治疗方法,脐血干细胞移植为其生存带来了希望。详细论述了脐血、干细胞与伦理学,肌萎缩侧索硬化与生命伦理学的关系,以及如何在肌萎缩侧索硬化治疗中体现生命伦理学的核心精神。面对脆弱的生命,医务人员、伦理学者和管理部门应该如何为此类疾病患者生命和健康作出应尽的职责。     

论中药品种保护中的法律责任

中药品种保护是不同于专利保护、商标保护的一种新的中药保护模式。它带有浓厚的行政保护色彩。为了更好的保护我国中药知识产权,规范中药的生产和销售行为,应当完善现有的中药品种保护制度,重构中药品种保护中的责任机制,与其他知识产权保护方式相互结合,形成中药知识产权保护体系。     

对手术同意书的法律思考

手术同意书是现代医疗制度中的重要医疗文书.从法律角度看,它具有医务人员职务行为、履行注意义务、履行告知义务及医疗行为合法性等证明效力的法律属性,也具有患者自愿作出选择并授权医方实施手术法律效力,但不具有免除医疗机构责任的效力.由此,需要对手术同意书签字权、内容和形式、手术相关情况的告知过程等加以完善.     

中医药的专利权保护

中医药为中华民族和世界人民的健康做出了重要贡献,但是由于我国对中医药知识产权保护的落后,我国中医药的珍贵知识财富正为外国大公司无偿地攫取.根据中医药自身的特性,对专利保护的适用、调整、改进及补充作了大胆设想,为我国进一步完善中医药的专利法保护提出了建议.     

《管子·轻重》成书当在战国时代

通观《轻重》各篇内容,无论从时代背景、从封君与“乡州”地方政府、郡县制度、从战国田齐政权“王天下”与春秋齐桓公时“尊王攘夷”的政治形势不同、从田齐货币、从田齐“釜、钟”等量具、从租金形式等方面来看,《管子.轻重》著作年代在田齐威、宣王或稍后的战国时代,而并非春秋齐桓公、管仲的时代,也非汉代。     

参加授（升）箓的一些感想

为提高道教的自身文化建设和道风建设,中国道教协会在著名的道教圣地道教祖庭江西龙虎山天师府举行正一派道士授(升)箓活动。我能有幸参加这次学习交流活动,感到非常高兴和欣慰。这无形地激发了我的学习兴趣,提升了我们的上进精神。