Cognitive and motor deficits in older adults with HIV infection: Comparison with normal ageing and Parkinson’s disease

Despite the life-extending success of antiretroviral pharmacotherapy in HIV infection (HIV), the prevalence of mild cognitive impairment in HIV remains high. Near-normal life expectancy invokes an emerging role for age–infection interaction and a potential synergy between immunosenescence and HIV-related health factors, increasing risk of cognitive and motor impairment associated with degradation in corticostriatal circuits. These neural systems are also compromised in Parkinson’s disease (PD), which could help model the cognitive deficit pattern in HIV. This cross-sectional study examined three groups, age 45–79 years: 42 HIV, 41 PD, and 37 control (CTRL) participants, tested at Stanford University Medical School and SRI International. Neuropsychological tests assessed executive function (EF), information processing speed (IPS), episodic memory (MEM), visuospatial processing (VSP), and upper motor (MOT) speed and dexterity. The HIV and PD deficit profiles were similar for EF, MEM, and VSP. Although only the PD group was impaired on MOT compared with CTRL, MOT scores were related to cognitive scores in HIV but not PD. Performance was not related to depressive symptoms, socioeconomic status, or CD4⁺ T-cell counts. The overlap of HIV-PD cognitive deficits implicates frontostriatal disruption in both conditions. The motor-cognitive score relation in HIV provides further support for the hypothesis that these processes share similar underlying mechanisms in HIV infection possibly expressed with or exacerbated by ageing.     

Family Functioning, Identity, and Problem Behavior in Hispanic Immigrant Early Adolescents

The present study investigated the role of identity in the relationship between family functioning and behavior problems in a sample of Hispanic immigrant early adolescents and their families. The sample consisted of 181 Hispanic immigrant adolescents (92 males, 89 females) and their participating caregivers (who were mostly mothers). Identity was measured using adolescent reports, whereas family functioning and early adolescent behavior problems were measured using both adolescent and parent reports. Correlational analyses indicated that previously obtained relationships among family functioning, identity, and behavior problems were replicated in the present sample. Structural equation models indicated that 20% of the relationship between family functioning and behavior problems operated indirectly through identity, and identity confusion partially mediates the relationship between family functioning and early adolescent behavior problems. Implications for intervention are discussed.