Cognitive flexibility mediates the relation between intolerance of uncertainty and safety signal responding in those with panic disorder

There is a growing literature associating anxiety disorders with an inability to inhibit defensive responding during safety conditions of threatening tasks. However, investigations on the relation between panic disorder (PD) and defensive responding to safety have yielded mixed results. A recent study from our laboratory revealed that intolerance of uncertainty (IU) moderates this association, such that only individuals with PD and a high IU exhibit heightened startle potentiation during safety. The mechanism underlying this relationship is unknown. Given that safety conditions typically alternate with periods of threat, cognitive flexibility (i.e., the ability to adjust one's habitual responding to a situation, given the input of new information) may be involved in the ongoing reappraisal of danger and adjustment of defensive responding. Thus, the present study sought to investigate whether deficits in cognitive flexibility mediate the association between IU and defensive responding to safety among a sample of 71 adults diagnosed with PD. As hypothesised, cognitive flexibility mediated the relationship between IU and heightened startle potentiation during safety conditions. This finding suggests that within this subgroup, a failure to inhibit defensive responding during safety conditions may be due to deficits in cognitive flexibility.     

Peripheral oxytocin administration buffers autonomic but not behavioral responses to environmental stressors in isolated prairie voles

Negative social experiences such as social stressors and isolation influence mental and physical illnesses, including affective disorders and heart disease. Studies focused on socially monogamous prairie voles can provide insight into neurobiological systems that underlie the consequences of negative social interactions. Female prairie voles were exposed to 28 days of social isolation or pairing with a female sibling (control). Voles were administered daily oxytocin [20 μg/50 μl, subcutaneous (sc)] or saline vehicle (50 μl, sc) for 14 days and exposed to two behavioral stressors [elevated plus maze (EPM) and resident-intruder test]. Brain tissue was collected for analysis of central peptide levels in the hypothalamic paraventricular nucleus (PVN). Isolation produced autonomic changes [increased heart rate (HR) and decreased HR variability) during both acute stressors and increased anxiety behaviors in the EPM. Oxytocin injection prevented the autonomic consequences of the acute stressors in isolated prairie voles, but did not affect the behaviors tested under the present conditions. Oxytocin had no effect on the behavioral or autonomic responsiveness in paired prairie voles. Oxytocin injection may exert a beneficial effect on autonomic responses to stressors in isolated animals through increasing the number of oxytocin-containing neurons and decreasing the number of corticotropin-releasing hormone-containing neurons in the PVN. Oxytocinergic mechanisms may serve to compensate for autonomic responses associated with chronic isolation and exposure to both social and non-social acute stressors.     

Object interest in autism spectrum disorder: a treatment comparison

A randomized control trial comparing two social communication treatments for children with autism spectrum disorder examined the effect of treatment on object interest. Thirty-two children, 18-60 months, were randomly assigned to the Picture Exchange Communication System (PECS) or Responsive Education and Prelinguistic Milieu Teaching (RPMT) condition. Assessment of object interest was conducted in an unstructured play session with different toys, activities, adult, and location than experienced in treatment. Results indicated children in the RPMT condition showed greater increases in object interest as compared to children in the PECS condition. Because child characteristics such as interest in objects may influence response to interventions using object play as contexts for treatment, it is important to improve our understanding of whether intervention can affect object interest.     

Identifying mediators of training effects on performance-related psychobiosocial states: A single-case observational study in an elite female triathlete

ObjectivesRelationships between training load, psychobiosocial (PBS) states and performance are dynamic and individual-specific. The nature of these relationships can be investigated using a combination of dynamic linear models (DLMs) and mediating variable analysis, potentially assisting applied sports psychologists in planning and monitoring of individual elite athletes’ intervention programmes.DesignWe illustrate this approach by examining the relationships of training loads with a performance-related state (‘self-efficacy’) and the role of potential mediating PBS variables (‘fatigue/lack of energy’ and ‘being in shape’) in explaining these relationships in an elite triathlete across time.MethodSelf-reports of PBS states (twice weekly) and training data were collected over 137 days. Using DLMs and mediating variable analysis, direct (unmediated) and indirect (mediated) short-term associations of training load with ‘self-efficacy’ were examined.ResultsIn this triathlete, we found evidence for positive effects of training on ‘self-efficacy’, which were partly explained by feelings of ‘being in shape’ and suppressed by feelings of ‘fatigue/lack of energy’. Changes in the relationship between lagged training load and ‘fatigue/lack of energy’ were observed across time and were particularly pronounced in temporal proximity of an injury.ConclusionStrengths of the presented approach are its dynamic nature enabling the observation of changes occurring over time, use of statistical inference rather than visual data interpretation, and quantification of mediating effects to identify potential pathways of intervention. Additionally, the DLM method can identify complex nonlinear associations by examining correspondence between changes in levels of predictors and changes in magnitude and direction of predictor-outcome associations.     

Following Foucault: Tall stories of mapping and inhabiting Pierre Rivière's landscapes as a 21st century inquiry

This paper documents the research methods adopted in a series of workshops on Pierre Rivière that took place at the University of Bristol. A group of scholars from Europe and Australia used philosophical, narrative, performative and artful approaches to re-examine the life of Pierre Rivière and family as documented by Michel Foucault (1975) and his team. They watched the film of the book (Allio, 1976) listened to emerging papers and wrote themselves into pivotal moments within the narratives they heard. They conducted narrative family therapy sessions with the ‘Rivière family’ and wrote themselves into the ensuing moments of evocation and connection. They made dolls, and wrote themselves into the voices of those dolls, and they gave presentations about how Pierre Rivière might be positioned within contemporary therapeutic, educational and media discourses. They wanted to find out if different kinds of knowledge might emerge from these ways of doing research differently. And yet it seemed that whatever form of inquiry they undertook, other subliminal, imaginary, fantasy and folk and fairy tale narratives seeped under efforts to produce rational, coherent academic texts. This paper explores this dual process of investigation in real time accompanied by eruptions into imaginary folklore and fairy story times, with segues into contemporary, fantastical stories of horror and murder. Each step the research team took became a doubled step, involving doubled listening and doubled knowing. To this end they have represented their research process (after Lather, 2007) as a doubled text and yet they have still not fully captured the emotional space of the workshops they inhabited. It was as if they were, for the short, intense period of time they were working together, collectively emotionally disassociated.     

The role of prior quitting experience in the prediction of smoking cessation

Aims: In the Transtheoretical Model (TTM), the preparation stage (as applied to smoking cessation) is defined as planning to quit in the next 30 days plus having quit for at least 24 h in the last year. This study examined the value of prior quitting experience as a stage classification criterion by investigating whether prediction of making a quit attempt differed as a function of prior quitting experience. Participants: One thousand and forty-six participants, all planning to quit in the next 30 days, in a randomised trial of the effectiveness of a telephone counselling and computer-generated tailored advice intervention were followed up at 3 months. Findings: A multivariate predictive model had markedly greater capacity to predict making a quit attempt among participants with prior quitting experience (as defined in several different ways), compared to analyses of the overall sample. A previous attempt of 24 h in the previous month was associated with the greatest difference in prediction. A quit attempt in the previous year (the TTM definition) did not discriminate. Conclusions: Recent prior quitting experience moderated the predictive capacity of some variables that influence smoking cessation. The findings provide some support for a stage model of smoking cessation but not its operationalisation by the TTM.