Accelerated development of cardiac sympathetic responses in spontaneously hypertensive (SHR) rats

The functional development of cardiac and adrenal medullary responses to reflex activation of the sympathetic nervous system was studied in preweanling spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) normotensive rats. Pups of the two strains received injections of insulin or saline at 2, 4, 8, 12, or 16 days of age and were sacrificed 3 h later. Insulin administration produces a significant decrease in circulating levels of glucose which in turn results in a centrally mediated increase in sympathetic outflow. The induction of ornithine decarboxylase (ODC) in heart and the depletion of epinephrine from the adrenal medulla served as tissue markers of functional sympathetic neurotransmission. WKY and SHR pups had comparable levels of ODC activity in heart under basal conditions. In contrast, levels of catecholamines in the adrenals were greater in SHR pups at 2 and 4 days of age. Following insulin administration, SHR pups exhibited a greater induction of cardiac ODC activity at 2, 4, and 8 days of age compared to age-matched WKY controls. However, there were no differences between SHR and WKY pups in the magnitude of the adrenal medullary response to insulin-induced hypoglycemia. These alterations in sympathetic-target tissue development during the first postnatal week of life may contribute in part to the higher arterial pressures maintained by SHRs throughout the lifespan.     

Family crisis intervention: fish or fowl?

This paper considers the status of family intervention as an area of interest defined by its literature (70 publications) and includes a brief history, assessment of present status, and recommendations for future development of family crisis intervention as a distinct field with concepts and goals that can be clearly defined, taught, researched, and repeated in treatment. Recommendations are made for the development of an explicit paradigm for intervention with a clear, common language of terms and concepts for family involvement. Suggested directions for developing the paradigm and language are explored.     

Visual stimuli on the Commodore Amiga: A tutorial

The Commodore Amiga home microcomputer, together withDeLuxePaint, a commercial software package, can generate many useful visual stimuli, including random-dot stereograms, apparent motion, texture edges, aftereffects from dimming and brightening, motion aftereffects, dynamic random noise, and drifting and counterphase gratings. Videotapes can readily be made of these displays. No programming experience is necessary.     

Prosocial orientation and COVID-19 vaccine willingness in the U.S.

Despite evidence of the safety and effectiveness of COVID-19 vaccines and their wide availability, many in the U.S. are not vaccinated. Research demonstrates that prosocial orientations predict COVID-19 health behaviors (e.g., social distancing) and vaccination intentions, however, little work has examined COVID-19 vaccination willingness in the U.S. since vaccines were approved. Findings from two U.S. samples show that, in contrast to other COVID-19 health behaviors, vaccine willingness in unvaccinated people is unrelated to prosocial orientation. Study 2 demonstrates that the lack of association between vaccine willingness and prosocial orientation in unvaccinated participants was specific to those with stronger beliefs that COVID-19 vaccines are ineffective. Thus, in prosocial people, perceptions of vaccines' ineffectiveness may undermine COVID-19 vaccine willingness.     

On the detectability of straight lines in visual noise: An extension of French’s paradigm into the millisecond domain

We report the results of a study that investigated the effects of four experimental parameters on the tachistoscopic detectability of dotted lines in a noisy background consisting of dynamic patterns of identical dots. Characteristics of the lines that were explored included dot spacing, dot numerosity, and line orientation. Dot spacing was shown to be the most powerful parameter in determining the masking effect: the closer the dots, the more easily the line was detected. Increasing the number of the dots was also effective in increasing the detectability of a line, but only up to a limit of five dots. The orientation of the line, on the other hand, did not alter its detectability. Increasing the density of the visual masking noise monotonically reduced the detectability of the line. These studies are an extension of French’s (1953, 1954) work, differing mainly in the fact that the stimulus material was presented tachistoscopically rather than in a mode that allowed prolonged (up to 5 sec) examination of the figures. Thus, they put the results in a domain in which physiological interpretations may be more critically evaluated. A comparison of the results suggests that essentially the same sorts of cognitive mechanisms are operating in the millisecond domain as in the longer exposures. This suggests that simple neurological models utilizing the concept of feature filters or detectors may be being prematurely applied to relatively complex perceptual processes.     

Triadic consistency and false heart-rate feedback

Subjects viewed slides of the Rorschach cards while listening to heart sounds that were supposedly but not actually their own. For some of the subjects the heart rate increased when they were exposed to the five achromatic cards and for some subjects the heart rate increased when they were exposed to the five chromatic cards. In addition, some subjects were told that increased heart rate was a sign of mental health (positive condition), and some that the increased heart rate was a sign of mental abnormality (negative condition) Since the heart-rate increase (behavior) and Rorschach cards associated with the increase (attitude object) are connected by a positive causal relation, triadic theory predicts that the sign of the heart-rate increase should generalize to the associated cards (i e, be positive in the positive condition and negative in the negative condition) An analysis of variance revealed such an overall significant effect Closer examination of the data, however, revealed that the triadic effects were not unambiguously occurring when the increased heart rate was associated with achromatic cards It was suggested that in this condition the unique characteristics of the cards facilitated the generation of complicating anxiety. Supportive data for this interpretation were offered     

A Bayesian prediction of four-look recognition performance from one-look data

The hypothesis that a human O’s (S’s) performance in a visual recognition task can be modelled by Bayes’ theorem was investigated. Two Ss were run for 40 experimental sessions each. Their task was to specify the direction of the gap of tachistoscopically presented Landolt rings (Cs). There were four possible gap directions, and two experimental conditions. In one condition, S responded after each stimulus presentation. In the other, a fixed-observation condition, Ss responded after four consecutive presentations of a C. Exposure durations were such that performance under both conditions was greater than chance, but less than unity. Predictions of four-look performance from one-look data were made. Overall hit rates were predicted closely. The entire pattern of each S’s four-look data was also predicted reasonably well. Further tests of the model are currently under way.     

Nonsuicidal physically self-damaging acts in adolescents

To determine the frequency and correlates of nonsuicidal physically self-damaging acts in 12–14 year olds, a two stage epidemiologic survey with a self-administered questionnaire (N=3283) followed by a psychiatric interview of a subsample of the adolescents and their parents (N=444) was used. Prevalence estimates of interview validated nonsuicidal physically self-damaging acts were 2.46% in males and 2.79% in females. Significant relationships were found between nonsuicidal physically self-damaging acts and suicidal ideation, major depression and undesirable life events. Data suggest that physically self-damaging acts occur at substantial rates during early adolescence. The strong correlation between nonsuicidal self-destructive acts and both suicidal ideation and major depression clarifies prior conflicting reports in the literature and suggests that a history of self-damaging acts should be taken into consideration when evaluating for possible depression and suicide risk.     

CHANGING PROTECTIVE AND RISKY BEHAVIORS TO PREVENT CHILD-TO-PARENT TRANSMISSION OF CYTOMEGALOVIRUS

Child-to-parent transmission of cytomegalovirus may be reduced by increasing protective behaviors (handwashing and glove use) and decreasing risky behaviors (intimate contact between child and parent). This study showed that an educational intervention resulted in increases in reported and objective measures of protective behaviors and decreases in reported risky behaviors. Further study must determine if changes in protective and risky behavior are maintained and prevent cytomegalovirus transmission.