肿瘤疫苗治疗肿瘤的前景

肿瘤疫苗的发展已经历了一个多世纪,20世纪50年代,人们开始了自体肿瘤疫苗的研究.使肿瘤疫苗(主动性免疫治疗)成为继手术、放疗、化疗之后的肿瘤治疗方法.肿瘤疫苗作为主动特异性免疫治疗,在临床中起到越来越重要的作用,人们开始尝试利用多种方法制备肿瘤疫苗并利用其促进机体免疫应答,从整体细胞,分子水平调控机体对肿瘤的免疫.目前肿瘤疫苗的研制已取得很大进展,给人类战胜肿瘤提供很大希望。     

外科感染:古老的疾病严峻的挑战

外科感染是人类最古老的疾病,在控制外科感染方面我们已经取得了巨大的进步,但外科感染反而变得越来越复杂,我们面临的挑战也越来越严峻.面对挑战,我们应该采取全方位的对策.     

普通高中实施选修课的心理认可度及其影响因素——基于宁波市教师与学生群体的调查分析

以宁波市三种类型六所普通中学为样本,以学生群体和教师群体为对象,采用问卷评定法,以心理认可度为指标,探讨了普通中学师生对于实施选修课制度的主观评价及其相关因素.结果发现：整体而言,学生和任课教师对宁波市普通高中实施选修课的心理认可度较高;存在的主要问题,是学生对选修课学习效果的认可度较低,而教师对学校开展选修课的教学条件的认可度较低,且认为实施选修课制度的外部阻力较大;特色类和融通类学校落实选修课制度的观念性阻力较大;中老年教师对开设选修课的适应性较低.进一步完善选修课制度,需要从教师、学校和政府三个方面形成合力,共同推动旨在促进学生个性化发展的选修课制度的健康发展.     

群体共同经历影响不公平感知

以往研究考察了不公平经历如何影响个体的认知、情绪及行为。然而, 这些研究着重于考察个体“独自经历”不公平的现象, 而尚未有研究考察, 当个体与他人以群体身份共同经历不公平时, 不公平经历对个体的影响。3项实验采用改编的三人最后通牒博弈任务考察“群体共同经历”不公平如何影响个体的不公平感知。研究结果表明, 无论是通过“共同命运” (实验1)、轮流为群体做决策(实验2), 还是招募成对朋友(实验3)来操纵或凸显群体身份, 群体共同经历不公平, 相比独自经历不公平, 均显著降低(而非提升)了被试的不公平感知。研究结果对于社会及组织管理具有借鉴意义。     

On "risk" and reward: investigating state anhedonia in psychometrically defined schizotypy and schizophrenia

Anhedonia, defined as dysfunction in the experience of pleasant emotions, is a hallmark symptom of the schizophrenia spectrum. Of interest, it is well documented that patients with schizophrenia, at least as a group, do not show reductions in their state experience of pleasant stimuli. However, there is emerging evidence to suggest that individuals with schizotypy--defined as the personality organization reflecting the latent vulnerability for schizophrenia--do show these state deficits. This is paradoxical in that schizophrenia reflects a more pathological state in virtually every conceivable domain as compared with schizotypy. The present study examined self-reported affective reactions to neutral-, bad-, and good-valenced stimuli in individuals with psychometrically defined schizotypy and schizophrenia. Two separate control groups were also included, comprising psychometrically defined controls and stable outpatients with affective disorders. With no exceptions, the schizotypy group reported significantly less pleasant affect for each of the three conditions than each of the other groups. Conversely, the schizophrenia group did not statistically differ from the control groups for any of the conditions. Within both the schizotypy and schizophrenia groups, severity of negative symptoms/traits was associated with less pleasant report. We found that individuals with prominent negative symptoms and traits from the schizophrenia and schizotypy groups resembled each other in terms of state anhedonia. The present findings did not appear to reflect comorbid depression or anxiety. Our discussion centers on this apparent paradox in the schizophrenia spectrum--that individuals with schizotypy exhibit state anhedonia, whereas patients with schizophrenia do not.     

Understanding the Linguistic Turn and the Quest for Meaning: Historical Perspectives and Systematic Considerations

Although the linguistic turn is usually described in historical terms this article aims at combing the significant historical transitions with systematic philosophical considerations. Against the background of earlier rationalistic and empiricist trends particular attention is given to the successive epistemic ideals manifest in the conceptual rationalism of the Enlightenment, followed by the historicism of the 19 ^th century and subsequently by the linguistic turn. An assessment of these transitions will explore systematic issues, in particular the relationship between universality and what is individual, the difference between functional laws and type laws, and regarding the limits of concept formation the distinction between conceptual knowledge and concept-transcending knowledge. This distinction enables the introduction of a new understanding of the difference between rationalism and irrationalism. Apart from Dilthey the linguistic turn penetrated also the thought of thinkers such as Freud, Wittgenstein, Frankl, Heidegger, Habermas, Dooyeweerd and Gadamer, all of them (implicitly or explicitly) elaborated the initial criticism raised by Herder, Jacobi, Hamann, Heidegger and Gadamer against Kant‘s Critique of Pure Reason for neglecting language. After briefly referring to the connection between the linguistic turn and the idea of the meaningful construction of reality, the article ends with a concluding remark emphasizing the fact that no single concept-transcending usage of modal (aspectual) terms should be elevated above others or employed at the cost of other equally legitimate idea-statements.     

The Retarded Child. A Guide for Parents,Teachers and Social Workers by Herta Loewy

Abstract

Emotional abuse in childhood, in contrast to physical or sexual abuse, is a form of maltreatment which has been slow to receive widespread discussion. Categorizing emotional abuse highlights the ongoing realities of emotionally abused individuals. The five categories introduced here help to classify developmental problems, create treatment plans, and identify preventive opportunities. After a discussion of these categories, representative case histories from therapy groups are presented. These case histories are then traced through major phases of group therapy conducted within a structured setting and occurring on a time-limited basis.     

为什么贫困会削弱决策能力？三种心理学解释

贫困削弱决策能力的心理学解释有三种基本视角: 注意力损耗论认为个体的注意力易集中于资源匮乏的领域而忽略其他, 意志力损耗论认为抵制外在诱惑会消耗其意志力, 认知控制损耗论认为贫困者的经济决策在难度上高于其他决策。这三种有限心理资源的损耗会削弱贫困者的认知表现而诱发非理性决策。后续研究应注意澄清三大机制之间的区别, 分析贫困损耗认知的结果是否具有可逆性, 同时就已有结果的跨文化适用性做出验证。